Potential Biomarkers Associated with Pulmonary Vascular Disease

Circulating Endothelin 1 but Not Transforming Growth Factor-β Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study

Pasquale Totaro, Claudio Tirelli, Lucia Sacchi, Annalisa De Silvestri, Mara DeAmici, Fabrizio Grosjean, Giorgia Testa, Alessia Alloni, Eraldo Kushta, Riccardo Albertini, Teresa Rampino, Andrea Maria D’ArminiFoundation I.R.C.C.S. Policlinico San Matteo. University of Milan. University of Pavia. Italy Journal of Clinical MedicineJ Clin Med 2024; DOI: 10.3390/jcm13174977 AbstractBackground and objectives: Endothelin-1 (ET-1) and transforming growth factor-β (TGF-β) play […]

Circulating Endothelin 1 but Not Transforming Growth Factor-β Levels Are Reduced after Pulmonary Endarterectomy in Subjects Affected by Chronic Thromboembolic Pulmonary Hypertension: A Prospective Cohort Study Read More »

Omic-signature of bronchopulmonary dysplasia associated pulmonary hypertension in <1500g-birth-weight-infants with hemodynamically significant intracardiac shunt

Lucy Emery, Alexa Hughes, Christiana Oji-Mmuo, Patricia Silveyra, Vincent P. R. Aluquin, Ann Donnelly, Roopa SiddaiahPenn State Health College of Medicine and Penn State Health Children’s Hospital. Indiana University School of Medicine. United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03541-5 AbstractBackground: PDA and ASD are common intracardiac shunts noted in prematurely born infants. While there is evidence

Omic-signature of bronchopulmonary dysplasia associated pulmonary hypertension in <1500g-birth-weight-infants with hemodynamically significant intracardiac shunt Read More »

Relationship Between Urine Serotonin and Persistent Pulmonary Hypertension of the Newborn

Jamie L. Archambault, Teri L. Hernandez, Eva S. Nozik, Claire Palmer, Mairead Dillon, Ravinder J. Singh, Csabo Galambos, Cassidy A. DelaneyUniversity of Colorado. Mayo Clinic College of Medicine.United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114290 AbstractUrine serotonin (5-HT)/creatinine was lower at day of life 3 in newborns with pulmonary hypertension compared with controls, while the

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Multiple biomarkers are equivalent to clinical pulmonary arterial hypertension survival risk models

Megan Griffiths, Catherine E. Simpson, Jun Yang, Dhananjay Vaidya, Melanie K. Nies, Stephanie Brandal, Rachel Damico, Paul Hassoun, D. Dunbar Ivy, Eric D. Austin, Michael W. Pauciulo, Katie A. Lutz, Lisa J. Martin, Erika B. Rosenzweig, Raymond L. Benza, William C. Nichols, Cedric Manlhiot, Allen D. EverettJohns Hopkins University. University of Texas Southwestern. Children’s Hospital

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Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations

Elijah H. Bolin, Peter M. Mourani, Staphanie D. Byrum, Samuel G. Mackintosh, Amy M. Dossey, Michael J. Angtuaco, Dala Zakaria, Lawrence E. Greiten. Graham M. Strub, Haihong Zhang, Gresham T. RichterUniversity of Arkansas for Medical Sciences and Arkansas Children’s Research Institute. United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03450-7 AbstractApproximately 1000 children are born every year

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Prenatal Prognosis of Omphalocele Using Magnetic Resonance Imaging Measurement of Fetal Lung Volumes

Simon E. Dadoun, Matthew A. Shanahan, Christian M. Parobek, Brian A. Burnett, Alice King, Pamela Ketwaroo, Roopali V. Donepudi, April D. AdamsTexas Children’s Hospital and Baylor College of Medicine. United States American Journal of Obstetrics and Gynecology Maternal Fetal MedicineAm J Obstet Gynecol MFM 2024; DOI: 10.1016/j.ajogmf.2024.101457 AbstractBackground: Omphalocele is a congenital midline abdominal wall defect resulting

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Circulating High Mobility Group Box-1 Does Not Predict Pulmonary Arterial Hypertension in Children with Congenital Heart Disease: A Prospective Cohort Study

Bruno Caracci, Carolyne Pehora, Lee Benson, Benjamin E. Steinberg, Neil M. Goldenberg, Katherine TaylorHospital for Sick Children and University of Toronto. Canada Journal of Cardiothoracic and Vascular AnesthesiologyJ Cardiothorac Vasc Anesthesiol 2024; DOI: 10.1053/j.jvca.2024.07.020 AbstractObjectives: Pulmonary arterial hypertension (PAH) is a devastating complication of pediatric congenital heart disease (CHD). A recent study has identified the protein high

Circulating High Mobility Group Box-1 Does Not Predict Pulmonary Arterial Hypertension in Children with Congenital Heart Disease: A Prospective Cohort Study Read More »

The Characteristics and Two-Year Neurodevelopmental Outcomes of Home Oxygen Therapy among Preterm Infants with Bronchopulmonary Dysplasia: A Retrospective Study in a Medical Center in Taiwan

Han-Pi Chang, En-Pei Lee, Ming-Chou ChiangLinkou Chang Gung Memorial Hospital. Chang Gung University. Taiwan BiomedicinesBiomedicines 2024; 12:DOI: 10.3390/biomedicines12071564 AbstractHome oxygen therapy (HOT) is frequently used as a therapeutic strategy for children experiencing chronic oxygen dependency associated with bronchopulmonary dysplasia (BPD). Recent studies have highlighted substantial variations in the characteristics and outcomes of infants requiring oxygen, primarily

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Down syndrome and postoperative hemodynamics in patients undergoing surgery for congenital cardiac communications

Eloisa Sassá Carvalho, JulianoGomes Penha, NairYukie Maeda, Kelly Cristina O. Abud, Maria Francilene S. Souza, Claudia R. P. Castro, Johnny X. dos Santos, Juliana Pereira, Antonio Augusto LopesUniversity of São Paulo School of Medicine. Brazil Scientific ReportsSci Rep 2024; 14: DOI: 10.1038/s41598-024-67097-4 AbstractAlthough Down syndrome (DS) is considered a risk factor for hemodynamic instabilities (mainly pulmonary

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Identifying Key Biomarkers in Pediatric Pulmonary Hypertension: An Investigative Approach

Farida Mindubayeva, Lyudmila Akhmaltdinova, Mariya Ospanova, Bibigul Tukbekova, Zhanat Bolatbekuly, Yuliya Niyazova, Yelena Salikhova, Olga Avdienko, Meruert AkhmetovaKaraganda Medical University. Multiprofile Hospital No. 2 of Karaganda.Kazakhstan ChildrenChildren 2024; DOI: 10.3390/children11060737 AbstractThis study assesses the utility of early biomarkers-5-hydroxyindoleacetic acid (5-HIAA) and insulin-like growth factor 1 (IGF-1)-for diagnosing and monitoring pulmonary hypertension (PH) in children with congenital

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