Potential Biomarkers Associated with Pulmonary Vascular Disease

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets

MengzeWang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie DingKunming Children’s Hospital. Southern Medical University. Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Taizhou Central Hospital (Taizhou University Hospital). Second Hospital of Jiaxing and Second Affiliated Hospital of Jiaxing University. Zhejiang Rongjun Hospital. […]

Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets Read More »

Increased hepcidin levels in high-altitude pulmonary edema

Sandro Altamura, Peter Bärtsch, Christoph Dehnert, Marco Maggiorini, Günter Weiss, Igor Theurl, Martina U. Muckenthaler, Heimo MairbäurlUniversity Hospital Heidelberg. University Hospital Zürich. Medical University of Innsbruck. Germany, Switzerland and Austria Journal of Applied PhysiologyJ App Physiol 2015; 118: 292-298 DOI: 10.1152/japplphysiol.00940.2014 AbstractLow iron availability enhances hypoxic pulmonary vasoconstriction (HPV). Considering that reduced serum iron is caused

Increased hepcidin levels in high-altitude pulmonary edema Read More »

Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study

Kevin R. Barker, Andrea L. Conroy, Michael Hawkes, Holly Murphy, Prativa Pandey, Kevin C. KainUniversity of Toronto and University Health Network-Toronto General Hospital. University of Alberta. CIWEC Hospital and Travel Medicine Center. Canada and Nepal Journal of Travel MedicineJ Travel Med 2016; 23: DOI: 10.1093/jtm/taw005 AbstractBackground: The mechanisms underlying acute mountain sickness (AMS) and high-altitude pulmonary edema

Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study Read More »

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway

Zongbin Li, Miao Zhao, Shanshan Ma, Shuyu LeiThird People’s Hospital of Xinjiang Uygur Autonomous Region. China European Journal of Medical ResearchEur J Med Res 2025; DOI: 10.1186/s40001-025-03586-0 AbstractBackground: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) drives lethal pulmonary vascular remodeling. While circular RNAs (circRNAs) are emerging as disease regulators, their functional roles in PAH-CHD remain

Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway Read More »

Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications

Xiaoyu Zhang, Liming Cheng, Jiahui Xie, Xuejuan Ma, Wenting Gui, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Kunming Children’s Hospital, Chinese Academy of Medical Sciences and Affiliated Cardiovascular Hospital of Kunming Medical University. China Frontiers in PhysiologyFront Physiol 2025; 14: DOI: 10.3389/fphys.2025.1673181 AbstractBackground: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling

Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications Read More »

Can N-terminal pro-brain natriuretic peptide accurately diagnose chronic pulmonary hypertension among extremely low gestational age neonates: A Retrospective Cohort Study

Macarena Garcia Gozalo, Amish Jain, Dany E. Weisz, Bonny JasaniLa Paz University Hospital.  Mount Sinai Hospital. University of Toronto. Sunnybrook Health Sciences Centre. Hospital for Sick Children.Spain and Canada Journal of PerinatologyJ Perinatol 2025; DOI: 10.1038/s41372-025-02462-3 AbstractObjective: To evaluate the utility of N-terminal pro-brain natriuretic peptide (NT pro-BNP) for screening and diagnosis of chronic pulmonary hypertension (cPH)

Can N-terminal pro-brain natriuretic peptide accurately diagnose chronic pulmonary hypertension among extremely low gestational age neonates: A Retrospective Cohort Study Read More »

Gene and metabolite changes triggered by downregulation of JUNB and ZNF281 in idiopathic pulmonary arterial hypertension: potential mechanisms revealed by multi-omics study

Yanfang Zong, Wei Liu, Jiahe Tian, Cuilan Hou, Tingting Xiao, Sirui Song, Xunwei JiangShanghai Children’s Hospital School of Medicine and Shanghai Jiao Tong University.China Translational PediatricsTransl Pediatr 2025; 14: 2572-2585DOI: 10.21037/tp-2025-370 AbstractBackground: Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease causing right heart failure. Idiopathic PAH (IPAH), a type of PAH with unknown causes, has

Gene and metabolite changes triggered by downregulation of JUNB and ZNF281 in idiopathic pulmonary arterial hypertension: potential mechanisms revealed by multi-omics study Read More »

Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review

Sagad O.O. Mohamed, Amged Mohammed, Fatima S.K. Salih, Hozifa A.M. Elgadal, Ayman A.A. Elsamany, Mohamed S.K. Salih, Huda M.A. Mustafa, Israa Elawad, Mona G.A. Ahmedkaroum, Safaa G.A. Saeed, Rowa E.A. Ibrahim, Esraa A. Mohamedien, Aya A.H. Babiker, Esraa T. Suliman, Eman O.E. MohamedUniversity of Khartoum. Médecins Sans Frontières. University of Bahri. Ibri Regional Hospital. Harlem

Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review Read More »

Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study

Hamdy El-Sayed, Hala Elmarsafawy, Basma Shouman, Mostafa Mansour, Amal OsmanMansoura University.Egypt Archive de PédiatrieArch Pediatr 2025; DOI: 10.1016/j.arcped.2025.08.004 AbstractBackground: Pediatric pulmonary arterial hypertension (PAH) is a potentially fatal disease. New targeted therapies based on the underlying pathogenesis are still needed.Objective: This study aims to evaluate the role of leukotriene E4, an inflammatory mediator, in developing pediatric pulmonary arterial

Urinary leukotriene E4 in pediatric pulmonary arterial hypertension: a pilot case control study Read More »

International Society for Heart and Lung Transplantation (ISHLT) Consensus Statement on Risk Stratification in Pulmonary Arterial Hypertension

Sandeep Sahay 1, Scott Visovatti 2, Adriano R Tonelli 3, Nelson Villasmil Hernandez 4, Eric D Austin 5, Roberto Badagliacca 6, Rolf M F Berger 7, Athénaïs Boucly 8, Yucheng Chen 9, Colin Church 10, Marion Delcroix 11, Allen D Everett 12, Harrison W Farber 13, Charles Fauvel 14, Mardi Gomberg-Maitland 15, Megan Griffiths 16, Francois Haddad 17, Yuchi Han 18, Anna Hemnes 5, Marius M Hoeper 19, Manreet K Kanwar 20, Daniel Lachant 21, Sandhya Murthy 22, Karen M Olsson 19, Ioana Preston 23, Göran Rådegran 24, Olivier Sitbon 25, Maria G Trivieri 26, Jean-Luc Vachiery 27, Rebecca Vanderpool 2, Jason Weatherald 28, R James White 21, Helen Whitford 29, Melisa Wilson 30, Raymond L Benza  Houston Methodist Hospital. Ohio State University.

International Society for Heart and Lung Transplantation (ISHLT) Consensus Statement on Risk Stratification in Pulmonary Arterial Hypertension Read More »

Scroll to Top