Potential Biomarkers Associated with Pulmonary Vascular Disease

Serum pentraxin 3 levels in term neonates with persistent pulmonary hypertension

A. E. A. Asal, Z. F. Oshaiba, E. N. A. Mansour, O. H. Abd Elazir, A. A. A. NasrAl-Azhar University (for girls).Egypt Journal of Neonatal and Perinatal MedicineJ Neonatal Perinatal Med 2024;DOI: 10.3233/NPM-230211 AbstractBackground: Persistent pulmonary hypertension of the neonate (PPHN) is a serious disorder. The long pentraxin 3 (PTX3) plays an important role in angiogenesis, cell […]

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Prognostic and diagnostic utility of interleukin-6 in pediatric pulmonary arterial hypertension – a case-control study

Mohamed Abdallah Abd El Megied, Mohammed Ahmed Abouelhassan, Eman Saad Abd El Salam HadwaCairo University.Egypt European Journal of PediatricsEur J Pediatr 2024;DOI: 10.1007/s00431-023-05413-2 AbstractPulmonary arterial hypertension (PAH) in pediatrics is a progressive disease with significant vascular remodeling, right sided heart failure, and death if left untreated. Elevated interleukin-6 (IL-6) level in PAH patients is taken as

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Association of the respiratory severity score with bronchopulmonary dysplasia-associated pulmonary hypertension in infants born extremely preterm

Lindsey Beer, Brian K. Rivera, Waceys Jama, Jonathan L. Slaughter, Carl H. Backes, Sara Conroy, Matthew J. KieltNationwide Children’s Hospital, Abigail Wexner Research Institute at Nationwide Children’s Hospital and Ohio State University College of Medicine.United States Journal of PerinatologyJ Perinatol 2023; DOI: 10.1038/s41372-023-01798-y AbstractObjective: To test the hypothesis that elevations in the respiratory severity score (RSS) are

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Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension

Catherine E. Simpson, Anjira S. Ambade, Robert Harlan, Aurelie Roux, Susan Aja, David Graham, Ami A. Shah, Laura K. Hummers, Anna R. Humnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman-Rosenzweig, Gabrielle Grunig, Michaela A. Aldred, John Barnard, Suzy A. A. Comhair, W. H. Wilson Tang, Megan Griffiths, Franz Rischard, Robert P. Frantz, Serpil

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Identification of protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid

Sumit Bhutada, Karin Tran-Lundmark, Benjamin Kramer, Peter Conner, Ashley M. Lowry, Eugene Blackstone, Bjorn Frenckner, Carmen Mesas-Burgos, Suneel S. ApteCleveland Clinic. Wallenberg Center for Molecular Medicine and Lund University. Skane University Hospital. Karolinska Institute. United States and Sweden Scientific ResearchSci Res 2023; 13DOI: 10.1038/s41598-023-42576-2 AbstractCongenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with

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Low-affinity insulin-like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival

Guillermo Torres, Andrew C. Lancaster, Jun Yang, Megan Griffiths, Stephanie Brandal, Rachel Damico, Dhananjay Vaidya, Catherine E. Simpson, Lisa J. Martin, Michael W. Pauciulo, William C. Nichols, D. Dunbar Ivy, Eric D. Austin, Paul M. Hassoun, Allen D. EverettJohns Hopkins University. University of Texas Southwestern Medical Center. Cincinnati Children’s Hospital Medical Center and University of

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Evaluation of preterm infants having bronchopulmonary dysplasia with echocardiography and serum biomarkers

O. Pamukcu, N. Narin, S. Sunkak, A. TuncayErciyes University School of Medicıne.Turkey Cardiology in the YoungCardiol Young 2023; DOI: 10.1017/S1047951123001361 AbstractBackground and objectives: Pulmonary hypertension is frequent in infants with bronchopulmonary dysplasia. Echocardiography is easy to perform, non-invasive, and recommended by guidelines even though solely it is not enough. Catheterisation is gold standard but invasive, expensive, and

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The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes

Mohamed Ahmed, Nancy G. Casanova, Nahla Zaghloul, Akash Gupta, Marisela Rodriguez, Ian R. Robbins, Carrie L. Kempf, Xiaoguang Sun, Jin H. Song, Vivian Reyes Hernon, Saad Sammani, Sara M. Camp, Alvaro Moreira, Chaur-Dong Hsu, Joe G. N. GarciaUniversity of Arizona Health Sciences. UT Health San Antonio Long School of Medicine. United States Frontiers in PhysiologyFront

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Factors leading to supranormal cardiac index in pediatric pulmonary hypertension patients treated with parenteral prostanoid therapy

Kimberley G. Miles Paul J. Critser, Patrick D. Evers, Michelle Cash, Melissa Magness, Elizabeth Geers Meredith O’Neil, Zhiqian Gao, Nicholas J. Ollberding, Russel HirschCincinnati Children’s Hospital Medical Center and Cincinnati College of Medicine. Oregon Health and Sciences University. United States Pulmonary CirculationPulm Circ 2023;DOI: 10.1002/pul2.12264 AbstractParenteral prostanoid therapy (PPT) can result in supranormal cardiac index (SCI;

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Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension

Chen-Yu Jiang, Li-Wei Wu, Yi-Wei Liu, Bei Feng, Lin-Cai Ye, Xu Huang, Yang-Yang He, Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, Yi YanShanghai Children’s Medical Center. Henan University. Shanghaitech University. China Frontiers in ImmunologyFront Immunol 2023; DOI: 10.3389/fimmu.2023.1153573 AbstractObjective: Inflammation is recognized as a contributor in the development of pulmonary arterial hypertension

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