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Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature

Shelby Thomas, Sathiyanarayanan Manivannan, Vidu Garg, Brenda LillyNationwide Children’s Hospital and Ohio State University.United States Journal of Vascular ResearchJ Vasc Res 2022; 59: 163-175DOI: 10.1159/000522340 AbstractPulmonary arterial hypertension (PAH) is a chronic progressive disease with significant morbidity and mortality. The disease is characterized by vascular remodeling that includes increased muscularization of distal blood vessels and vessel […]

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Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle

Yan Bai, Xingbin AiMassachusetts General Hospital and Harvard Medical School.United States Journal of Visualized ExperimentsJ Vis Exp 2022; DOI: 10.3791/63932 AbstractSmooth muscle cells (SMC) mediate the contraction of the airway and the intrapulmonary artery to modify airflow resistance and pulmonary circulation, respectively, hence playing a critical role in the homeostasis of the pulmonary system. Deregulation of

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Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation

Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States Physiological ReportsPhysiol Rep 2022; DOI: 10.14814/phy2.15342 AbstractThe hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) respond to hypoxia with epidermal growth factor (EGF) mediated activation of the receptor tyrosine kinase, EGF

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Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease

Bin Wen, Rui Peng, Pengxu Kong, Zefu Li, Yao Liu, Wenbin Ouyang, Yongquan Xie, Xiaopeng Hu, Qiang Wang, Xiangbin PanNational Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Chao-Yang Hospital. Beijing Friendship Hospital. Beijing Anzhen Hospital and Capital Medical University.China American Journal of Respiratory Cell and

Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease Read More »

OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells

Paul Sidlowski, Amanda Czerwinski, Yong Liu, Pengyuan Liu, Ru-Jeng Teng, Suresh Kumar, Clive Wells, Kirkwood Pritchard Jr, Girija G. Konduri, Adeleye J. AfolayanMedical College of Wisconsin. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2022; DOI: 10.1165/rcmb.2022-0186OC AbstractMitochondrial function and metabolic homeostasis are integral to cardiovascular function and influence

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Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension

Lea C. Steffes, Maya E. KumarStanford University School of Medicine.United States Bio-protocolBio Protoc 2022; 12: DOI: 10.21769/BioProtoc.4273 AbstractPulmonary hypertension (PH) is a heterogenous and incurable disease marked by varying degrees of pulmonary vascular remodeling. This vascular remodeling, which includes thickening of the smooth muscle layer (an early finding) and formation of occlusive neointimal lesions (a late

Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension Read More »

Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension

Ruaa Al-Qazaz, Patricia D. A. Lima, Sasha Z. Prisco, Francois Potus, Asish Dasgupta, Kuang-Hueih Chen, Lian Tian, Rachel E. T. Bentley, Jeff Mewburn, Ashley Y. Martin, Danchen Wu, Oliver Jones, Donald H. Maurice, Sebastien Bonnet, Steeve Provencher, Kurt W. Prins,Stephen L. ArcherQueen’s University. University of Minnesota Medical School. Laval University. University of Strathclyde.Canada, United States

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Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life

Hironori Oshita, Hirofumi Sawada, Yoshihide Mitani, Naoki Tsuboya, Jane C. Kabwe, Junko Maruyama, Ali yusuf, Hiromasa Ito, Ryuji Okamoto, Shoichiro Otsuki, Noriko Yodoya, Hiroyuki Ohashi, Kazunobu Oya, Yuhko Kobayashi, Issei Kobayashi, Kaoru Dohi, Yuhei Nishimura, Shinji Saitoh, Kazuo Maruyama, Masahiro HirayamaMie University Graduate School of Medicine. Nagoya City University Graduate School of Medical Sciences. Suzuka

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Targeted treprostinil delivery inhibits pulmonary arterial remodeling

Aijun Liu, Bin Li, Ming Yang, Yongying Shi, Junwu SuBeijing Anzhen Hospital. The First Affiliated Hospital of Guangzhou Medical University. China European Journal of PharmacologyEur J Pharmacol 2022; 923: DOI: 10.1016/j.ejphar.2021.174700 AbstractIntroduction: Pulmonary arterial hypertension (PAH) is a fatal disease caused by the progressive remodeling of pulmonary arteries (PAs). Treprostinil (TPS) is a tricyclic benzidine prostacyclin clinically

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Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension

Michael H. Lee, Linda Sanders, Rahul Kumar, Daniel Henandez-Saavedra, Xin Yun, Joshay A. Ford, Mario J. Perez, Claudia Mickael, Aneta Gandjeva, Daniel E. Koyanagi, Julie W. Harral, David C. Irwin, Biruk Kassa, Robert H. Eckel, Larissa A. Shimoda, Brian B. Graham, Rubin M. TuderUniversity of California, San Francisco. University of Colorado. Johns Hopkins School of

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