No Age-Related Focus

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

Emmanuel Born, Larissa Lipskaia, Marielle Breau, Amal Houssaini, Delphine Beaulieu, Elisabeth Marcos, Remi Pierre, Marcio Do Cruzeiro, Marine Lefevre, Genevieve Derumeaux, Dmitry V. Bulavin, Marion Delcroix, Rozenn Quarck, Virinder Reen, Jesus Gil, Daviv Bernard, Jean-Michel Flaman, Serge Adnot, Shariq AbidUniversité Paris-Est Créteil. Université de Lyon. Institut Cochin. Institut Mutualiste Montsouris. nstitute for Research on Cancer

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Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

Jason G. E. Zelt, Virgilio Cadete, Yupu Deng, Rafael Godoy, Alexanne Cuillerier, Katelynn Rowe, Mohammad Abdul-Ghani, Lynn Megeney, Yan Burelle, Antonio Giulivi, Alexandre F. R. Stewart, Steeve Provencher, Sandra Breuils-Bonnet, Sébastien Bonnet, Robert deKemp, Rob Beanlands, Lisa M. Mielniczuk, Duncan J. StewartUniversity of Ottawa.Canada HypertensionHypertension 2022; 79: 2774-2786DOI: 10.1161/HYPERTENSIONAHA.122.19300 AbstractBackground: We explored the mechanism of maladaptive right

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics Read More »

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen, Anton Vonk Noordegraaf, Peter ten Dijke, Rudolf A. de Boer, Harm Jan Bogaard, Marie José Goumans, Rolf M. F. BergerLeiden University Medical Center. University of Groningen and Beatrix Children’s Hospital. Vrije Universiteit Amsterdam. University of Groningen and University Medical Center Groningen.Netherlands AngiogenesisAngiogenesis 2022; 25: 99-112DOI: 10.1007/s10456-021-09812-7 AbstractPulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling Read More »

G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Charifa Awada, Alice Bourgeois, Sara-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jevaseelan, Steeve ProvencherCentre de recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec. Janssen Research and Development. Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2023; DOI: 10.1165/rcmb.2022-0300OC AbstractPulmonary

G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension

Iona Cuthbertson, Nicholas W. Morrel, Paola CarusoUniversity of Cambridge School of Clinical MedicineUnited Kingdom Circulation ResearchCirc Res 2023; 132(1):109-126DOI: 10.1161/CIRCRESAHA.122.321554 AbstractPulmonary arterial hypertension forms the first and most severe of the 5 categories of pulmonary hypertension. Disease pathogenesis is driven by progressive remodeling of peripheral pulmonary arteries, caused by the excessive proliferation of vascular wall cells,

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Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia

Nzali V. Campbell, Claudia Mickael, Sushil Kumar, Hui Zhang, Ian L. Campbell, Austin E. Gillen, Caio O. Trentin, Katrina Diener, Bifeng Gao, Vitaly O. Kheyfets, Sue Gu, Rahul Kumar, Tzu Phang, R. Dale Brown, Brian B. Graham, Kurt R. StenmarkUniversity of Colorado. Stanford University. University of California San Francisco.United States American Journal of Physiology Lung

Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia Read More »

The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension

Sue Gu, Claudia Mickael, Rahul Kumar, Michael H. Lee, Linda Sanders, Biruk Kassa, Julie Harral, Jason Williams, Kirk C. Hansen, Kurt R. Stenmark, Rubin M. Tuder, Brian B. GrahamUniversity of Colorado. University of California San Francisco.United States Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12105 AbstractRight ventricular (RV) failure is the primary cause of death in pulmonary

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Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study

Rachelle Walter, Kendall Hunter, Kurt Stenmark, Vitaly O. KheyfetsUniversity of ColoradoUnited States Journal of Biomechanical EngineeringJ Biomech Eng 2022; 144: DOI: 10.1115/1.4051719 AbstractPulmonary hypertension (PH) is a progressive disease that is characterized by a gradual increase in both resistive and reactive pulmonary arterial (PA) impedance. Previous studies in a rodent model of PH have shown that

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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target

Stephen L. Archer, Glenn Marsboom, Gene H. Kim, Hannah J. Zang, Peter T. Toth, Eric C. Svensson, Jason R. B. Dyke, Mardi Gomberg-Maitland, Bernard Thébaud, Aliya N. Husain, Nicole Cipriani, Jalees RehmaneUniversity of Chicago. University of Alberta.United States and Canada CirculationCirculation 2010; 121: 2661-2671DOI: 10.1161/CIRCULATIONAHA.109.916098 AbstractBackground: Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle

Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target Read More »

Dysregulated Smooth Muscle Cell BMPR2–ARRB2 Axis Causes Pulmonary Hypertension

Lingli Wang, Jan Renier Moonen, Aigin Cao, Sarasa Isobe, Caiyun G. Li, Nancy F. Tojais, Shalina Taylor, David P. Marciano, Pi-I. Chen, Mingxia Xu, Dan Li, Rebecca L. Harper, Nesrine El-Bizri, YuMee Kim, Kryn Stankunas, Marlene RabinovitchStanford University School of Medicine, Howard Hughes Medical Institute, and Lucille Packard Children’s HospitalUnited States Circulation ResearchCirc Res 2023;

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