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Hippo signaling pathway and respiratory diseases

Weifeng Tang, Min Li, Xiaoting Yangzhong, Xifeng Zhang, Anju Zu, Yunjiao Hou, Lin Li, Shibo SunFirst Affiliated Hospital and Kunming Medical University. China Cell Death DiscoveryCell Death Discov 2022; 8: DOI: 10.1038/s41420-022-01020-6 AbstractThe hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, […]

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Common Variation in EDN1 Regulatory Regions Highlights the Role of PPARγ as a Key Regulator of Endothelin in vitro

Mauro Lago-Docampo, Carlos Solarat, Luis Méndez-Martínez, Adolfo Baloira, Diana ValverdeUniversidade de Vigo. Galicia Sur Health Research Institute . Institute of Marine Research. Complexo Hospitalario Universitario de Pontevedra.Spain Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; 9: DOI: 10.3389/fcvm.2022.823133 AbstractPulmonary Arterial Hypertension (PAH) is a rare disease caused by the obliteration of the pulmonary arterioles, increasing pulmonary vascular resistance

Common Variation in EDN1 Regulatory Regions Highlights the Role of PPARγ as a Key Regulator of Endothelin in vitro Read More »

A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device

Tanoy Sarkar, Trieu Nguyen, Sakib M. Moinuddin, Kurt R. Stenmark, Dipongkor Saha, Fakhrul AhsanCalifornia Northstate University College of Pharmacy. University of Colorado Denver, Anschutz Medical Campus. MedLuidics.United States MicromachinesMicromachines 2022; 13: DOI: 10.3390/mi13091483 AbstractPulmonary arterial hypertension (PAH) is a rare pulmonary vascular disease that affects people of all ethnic origins and age groups including newborns. In

A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device Read More »

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna KwapiszewskaLudwig Boltzmann Institute for Lung Vascular Research. Medical University of Graz. University of Pennsylvania. Medical University

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling Read More »

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis

Fan Hu, Hanmin Liu, Chuan Wang, Hanwen Li, Lina QiaoWest China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, and West China Hospital of Stomatology. Sichuan University. China Experimental and Therapeutic MedicineExp Ther Med 2022; 23: DOI: 10.3892/etm.2021.11031 AbstractThe biological processes of pulmonary artery vascular smooth muscle cells (PA-SMCs)

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis Read More »

Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model

Dongli Liu, Suyuan Qin, Danyan Su, Kai Wang, Yanyun Huang, Yuqin Huang, Yusheng PangThe First Affiliated Hospital of Guangxi Medical University. The First Affiliated Hospital of Wenzhou Medical University.China American Chemical Society OmegaACS Omega 2021; 7: 1273-1287DOI: 10.1021/acsomega.1c05895 AbstractPulmonary arterial hypertension (PAH) is a complex devastating disease relevant to remarkable metabolic dysregulation. Although various research studies

Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model Read More »

Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells

Chaoyi Qin, Yiheng Zan, LiangXie, Hanmin LiuWest China Hospital and Sichuan University. China Institute of Women’s and Children’s Health, West China Second University Hospital and Sichuan University. China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; DOI: 10.3389/fcvm.2022.942251 AbstractObjective: To study the role of ataxia telangiectasia mutated (ATM) in the platelet-derived growth factor (PDGF)-BB-induced proliferation of pulmonary arterial

Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells Read More »

An electrochemical nitric oxide generator for in-home inhalation therapy in pulmonary artery hypertension

Yiwei Liu, Yifan Zhu, Chenyu Jiang, Zhanhao Su, Yi Yan, Bei Feng, Wen Mao, Yuyan Zhang, Xiaojian Wang, Zhuoming Xu, Hao ZhangShanghai Children’s Medical Center and Shanghai Jiao Tong University. Fuwai Hospital and Chinese Academy of Medical Sciences and Peking Union Medical College. Ludwig Maximilian University Munich. artner site Munich Heart Alliance. Nanjing Novlead Biotechnology

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Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia

Tsering Stobdan, Pritesh P. Jain, Mingmei Xiong, Vineet Bafna, Jason X.-J. Yuan, Gabriel G. HaddadUniversity of California San Diego. Rady Children’s Hospital.United States Human Molecular GeneticsHum Mol Genet 2022; 31: 1130-1140DOI: 10.1093/hmg/ddab291 AbstractThe molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and

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Dichotomous role of integrin-β5 in lung endothelial cells

Neil Blanchard, Patrick A. Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D. Cool, Rebecca L. Heise, Robert Freishtat, Laszlo FarkasUniversity of Virginia. Ohio State University. Children’s National Health System. University of Colorado. Virginia Commonwealth University.United States Pulmonary CirculationPulm Circ 2022; DOI: 10.1002/pul2.12156 AbstractPulmonary arterial hypertension (PAH) is a progressive,

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