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Lactylation: novel epigenetic regulatory and therapeutic opportunities

Haoqin Fan, Fan Yang, Zhenghui Xiao, Haiyan Luo, Huaiyang Chen, Zhi Chen, Qiming Liu, Yunbin XiaoHengyang Medical School and University of South China. Hunan Children’s Hospital. Second Xiangya Hospital, Central South University. China American Journal of Physiology Endocrinology and MetabolismAm J Physiol Endocrinol Metab 2023; 324: E330-E338DOI: 10.1152/ajpendo.00159.2022 AbstractLactate, which is an end product of glycolysis,

Lactylation: novel epigenetic regulatory and therapeutic opportunities Read More »

Hepatic factor may not originate from hepatocytes

Monica Merbach, Ramani Ramchandran, Andrew D. SpearmanMedical College of Wisconsin and Children’s Wisconsin.United States Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; DOI: 10.3389/fcvm.2022.999315 AbstractPulmonary arteriovenous malformations (PAVMs) develop universally in patients with univentricular congenital heart disease. They are believed to form due to lack of an unidentified factor from hepatocytes that perfuses the lungs to maintain

Hepatic factor may not originate from hepatocytes Read More »

Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study

Weili Yang, Pu Zhao, Ping Cao, Chunlin Miao, Xiang Ji, Ya Gao, Peng Li, Jiwen ChengThe Second Affiliated Hospital of Xi’an Jiaotong University. Shaanxi Provincial People’s Hospital.China Journal of Cellular BiochemistryJ Cell Biochem 2022; 123: 736-745DOI: 10.1002/jcb.30216 AbstractLittle is known about differentially expressed genes (DEGs) and alternative splicing (AS) landscapes in congenital lung malformations (CLMs). We

Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study Read More »

Notch signalling in healthy and diseased vasculature

Francesca Del Gaudio, Dongli Liu, Urban LendahlKarolinska Institutet. The First Affiliated Hospital of Guangxi Medical University.Sweden and China Open BiologyOpen Biol 2022; 12: DOI: 10.1098/rsob.220004 AbstractNotch signalling is an evolutionarily highly conserved signalling mechanism governing differentiation and regulating homeostasis in many tissues. In this review, we discuss recent advances in our understanding of the roles that

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Hippo signaling pathway and respiratory diseases

Weifeng Tang, Min Li, Xiaoting Yangzhong, Xifeng Zhang, Anju Zu, Yunjiao Hou, Lin Li, Shibo SunFirst Affiliated Hospital and Kunming Medical University. China Cell Death DiscoveryCell Death Discov 2022; 8: DOI: 10.1038/s41420-022-01020-6 AbstractThe hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development,

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Common Variation in EDN1 Regulatory Regions Highlights the Role of PPARγ as a Key Regulator of Endothelin in vitro

Mauro Lago-Docampo, Carlos Solarat, Luis Méndez-Martínez, Adolfo Baloira, Diana ValverdeUniversidade de Vigo. Galicia Sur Health Research Institute . Institute of Marine Research. Complexo Hospitalario Universitario de Pontevedra.Spain Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; 9: DOI: 10.3389/fcvm.2022.823133 AbstractPulmonary Arterial Hypertension (PAH) is a rare disease caused by the obliteration of the pulmonary arterioles, increasing pulmonary vascular resistance

Common Variation in EDN1 Regulatory Regions Highlights the Role of PPARγ as a Key Regulator of Endothelin in vitro Read More »

A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device

Tanoy Sarkar, Trieu Nguyen, Sakib M. Moinuddin, Kurt R. Stenmark, Dipongkor Saha, Fakhrul AhsanCalifornia Northstate University College of Pharmacy. University of Colorado Denver, Anschutz Medical Campus. MedLuidics.United States MicromachinesMicromachines 2022; 13: DOI: 10.3390/mi13091483 AbstractPulmonary arterial hypertension (PAH) is a rare pulmonary vascular disease that affects people of all ethnic origins and age groups including newborns. In

A Protocol for Fabrication and on-Chip Cell Culture to Recreate PAH-Afflicted Pulmonary Artery on a Microfluidic Device Read More »

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna KwapiszewskaLudwig Boltzmann Institute for Lung Vascular Research. Medical University of Graz. University of Pennsylvania. Medical University

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling Read More »

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis

Fan Hu, Hanmin Liu, Chuan Wang, Hanwen Li, Lina QiaoWest China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, and West China Hospital of Stomatology. Sichuan University. China Experimental and Therapeutic MedicineExp Ther Med 2022; 23: DOI: 10.3892/etm.2021.11031 AbstractThe biological processes of pulmonary artery vascular smooth muscle cells (PA-SMCs)

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis Read More »

Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model

Dongli Liu, Suyuan Qin, Danyan Su, Kai Wang, Yanyun Huang, Yuqin Huang, Yusheng PangThe First Affiliated Hospital of Guangxi Medical University. The First Affiliated Hospital of Wenzhou Medical University.China American Chemical Society OmegaACS Omega 2021; 7: 1273-1287DOI: 10.1021/acsomega.1c05895 AbstractPulmonary arterial hypertension (PAH) is a complex devastating disease relevant to remarkable metabolic dysregulation. Although various research studies

Metabolic Reprogramming of the Right Ventricle and Pulmonary Arteries in a Flow-Associated Pulmonary Arterial Hypertension Rat Model Read More »

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