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The effect of transglutaminase-2 inhibitor on pulmonary vascular remodeling in rats with pulmonary arterial hypertension

Ting Wang, Yan Duan, Dong Liu, Gang Li, Bin LiuThe Affiliated Hospital of Southwest Medical University, Luzhou.China Journal of Experimental HypertensionJ Exp Hypertens 2022; 44: 167-174DOI: 10.1080/10641963.2021.2013493 AbstractTo investigate the relationship between transglutaminase type 2 (TG2) and pulmonary vascular remodeling in the formation of pulmonary arterial hypertension (PAH), and to investigate the effect of the inhibitor […]

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Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in-vitro and pulmonary hypertension in mice

Tianji Chen, Miranda R. Sun, Qiyuan Zhou, Alyssa M. Guzman, Ramaswamy Ramchandran, Jiwang Chen, Balaji Ganesh, J. Usha RajUniversity of Illinois at Chicago. United States Pulmonary CirculationPulm Circ 2022; 12: DOI: 10.1002/pul2.12014 AbstractIn the lung, communication between pulmonary vascular endothelial cells (PVEC) and pulmonary artery smooth muscle cells (PASMC) is essential for the maintenance of vascular

Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in-vitro and pulmonary hypertension in mice Read More »

Large animal preclinical investigation into the optimal extracorporeal life support configuration for pulmonary hypertension and right ventricular failure

Rei Utika, John W. Stokes, W. Kelly Wu, Yatrik J. Patel, Jennifer R. Talackine, Nancy Cardwell, Clayne Benson, Ryan J. Lefevre, Susan Eagle, Caitlin Demarest, Elizabeth Simonds, Yuliya Tipograf, Michael Cortelli, David J. Skoog, Keith Cook, Erika B. Rosenzweig, Matthew BachettaVanderbilt University Medical Center. Advanced Respiratory Technologies LLC. Carnegie Mellon University. Columbia University Medical Center.United

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Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling

Takashi Yoshida, Tetsutaro Nagaoka, Yuichi Nagata, Yoshifumi Suzuki, Takeo Tsutsumi, Sachiko Kuriyama, Junko Watanabe, Shinsaku Togo, Fumiyuki Takahashi, Masakazu Matsushita, Yusuke Joki, HakuohKonishi, Satoshi Nunomura, Kenji Izuhara, Simon J. Conway, Kazuhisa TakahashiJuntendo University Faculty of Medicine and Graduate School of Medicine. Saga Medical School. Indiana University School of Medicine.Japan and United States RespirologyRespirology 2022; 27:

Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling Read More »

Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling

Guolun Wang, Bingqiang Wen, Zicheng Deng Arun Pradhan, Tanya V. Kalin, Yufang Zhang, Olena A. Kolesnichenko, Vladimir Ustiyan, Vladimir V. KalinichenkoCincinnati Children’s Hospital Medical Center and University of Cincinnati. United States Nature CommunicationsNat Commun 2022; DOI: 10.1038/s41467-022-29746-y AbstractPulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis and represent a subset of general capillary cells

Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling Read More »

Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension

Oscar van der Have, Timothy J. Mead, Christian Westoo, Niccolo Peruzzi, Ayse C. Mutgan, Christian Norvik, Martin Bech, Andre Struglics, Konrad Hoetzenecker, Hans Brunnstrom, Gunilla Westergren-Thorsson, Grazyna Kwapiszewska, Suneel S. Apte, Karin Tran-Lundmark Lund University and Skåne University Hospital. Cleveland Clinic. Ludwig Boltzmann Institute for Lung Vascular Research. Medical University Graz. Medical University of Vienna.

Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension Read More »

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

Emmanuel Born, Larissa Lipskaia, Marielle Breau, Amal Houssaini, Delphine Beaulieu, Elisabeth Marcos, Remi Pierre, Marcio Do Cruzeiro, Marine Lefevre, Genevieve Derumeaux, Dmitry V. Bulavin, Marion Delcroix, Rozenn Quarck, Virinder Reen, Jesus Gil, Daviv Bernard, Jean-Michel Flaman, Serge Adnot, Shariq AbidUniversité Paris-Est Créteil. Université de Lyon. Institut Cochin. Institut Mutualiste Montsouris. nstitute for Research on Cancer

Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression Read More »

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics

Jason G. E. Zelt, Virgilio Cadete, Yupu Deng, Rafael Godoy, Alexanne Cuillerier, Katelynn Rowe, Mohammad Abdul-Ghani, Lynn Megeney, Yan Burelle, Antonio Giulivi, Alexandre F. R. Stewart, Steeve Provencher, Sandra Breuils-Bonnet, Sébastien Bonnet, Robert deKemp, Rob Beanlands, Lisa M. Mielniczuk, Duncan J. StewartUniversity of Ottawa.Canada HypertensionHypertension 2022; 79: 2774-2786DOI: 10.1161/HYPERTENSIONAHA.122.19300 AbstractBackground: We explored the mechanism of maladaptive right

Right Ventricular Maladaptation to Pressure Overload in Fischer Rats Is Associated With Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics Read More »

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling

Kondababu Kurakula, Quint A. J. Hagdorn, Diederik E. van der Feen, Anton Vonk Noordegraaf, Peter ten Dijke, Rudolf A. de Boer, Harm Jan Bogaard, Marie José Goumans, Rolf M. F. BergerLeiden University Medical Center. University of Groningen and Beatrix Children’s Hospital. Vrije Universiteit Amsterdam. University of Groningen and University Medical Center Groningen.Netherlands AngiogenesisAngiogenesis 2022; 25: 99-112DOI: 10.1007/s10456-021-09812-7 AbstractPulmonary arterial hypertension (PAH) is a devastating disease, characterized by obstructive pulmonary vascular remodelling ultimately leading to right ventricular (RV) failure

Inhibition of the prolyl isomerase Pin1 improves endothelial function and attenuates vascular remodelling in pulmonary hypertension by inhibiting TGF-β signalling Read More »

G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

Charifa Awada, Alice Bourgeois, Sara-Eve Lemay, Yann Grobs, Tetsuro Yokokawa, Sandra Breuils-Bonnet, Sandra Martineau, Vinod Krishna, Francois Potus, Jey Jevaseelan, Steeve ProvencherCentre de recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec. Janssen Research and Development. Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2023; DOI: 10.1165/rcmb.2022-0300OC AbstractPulmonary

G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

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