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Development of a Novel Nanoparticle Targeting Endothelial Cells from Patients with Pulmonary Arterial Hypertension

Gabriel Floarea, Nasser Assi, Maytham Ismail, Anderson Gattis, Tadanori Mammoto, Akiko Mammoto, Mathumai KanapathipillaiUniversity of Michigan-Dearborn. Medical College of Wisconsin. United States MoleculesMolecules 2026; 31: DOI: 10.3390/molecules31193511 AbstractPulmonary arterial hypertension (PAH) is a devastating disease driven largely by oxidative stress and inflammation. The pulmonary arterial endothelium plays a key role in PAH pathogenesis. In this

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Macrophages Contribute to Pulmonary Hypertension Associated With Sickle Cell Disease

Christina Lisk, Francesca Cendali, Natalie Westover, Delaney Swindle, Daniel Colon Hidalgo, Caitlin Lewis, Melissa J. Lucero, Nishant K. Rana, Gemlyn George, Saini Setua, Monika Dzieciatkowska, Kathryn Hassel, Christy S. Niemeyer, Kurt Stenmark, Eva Nozik, Angelo D’Alessandro, Paul W. Buehler, David C. IrwinUniversity of Colorado Denver – Anschutz Medical Campus. Children’s Hospital Colorado. University of Maryland

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Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension

Yoshihito Morimoto, Yoshiaki Sato, Katsuhiro Kato, Hidenori Yamamoto, Kentaro Suzuki, Kiyotaka Go, Yoshie Fukasawa, Naoki Ohashi, Yoshiyuki Takahashi, Taichi KatoNagoya University Graduate School of Medicine and Nagoya University Hospital. National Cerebral and Cardiovascular Center. Japan Journal of Molecular and Cellular Cardiology PlusJ Mol Cell Cardiol Plus 2026; 18: DOI: 10.1016/j.jmccpl.2026.100867 AbstractRationale: Although plexiform lesion (PL)

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Chronic Mixed-Allergen Exposure Induces Pulmonary Arterial Remodeling and Vascular Dysfunction in Mice

Mohammad Irshad Reza, Maxwell Mathias, Venkatachalem Sathish University of Oklahoma Health Campus.United States American Journal of Physiology Lung Cullular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00238.2026 AbstractChronic asthma can be associated with secondary pulmonary vascular dysfunction, however, the detailed functional profiling of the asthmatic pulmonary artery remains understudied. In this study,

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Developing a Digital Twin of the Cardiopulmonary System in a Mouse: Inferring Hemodynamics from Sparse Measurements

Vitaly O. Kheyfets, Kenzo Ichimura, Paul M. Heerdt, Mengqian Zhang, Ella Lyon, Kurt R. Stenmark, Edda SpiekerkoetterUniversity of Colorado School of Medicine and University of Colorado Anschutz Medical Campus. Stanford University. Yale School of Medicine.United States Annals of Biomedical EngineeringAnn Biomed Eng 2026; DOI: 10.1007/s10439-026-04107-8 AbstractPurpose: The use of rodent models in the study of cardiopulmonary disease

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Post-translational modification crosstalk in pulmonary arterial hypertension: mechanisms and therapeutic implications

Jialin Liang, Yuxin Xie, Danyan Su, Yusheng Pangirst Affiliated Hospital of Guangxi Medical University. Guangxi University of Chinese Medicine. China Molecular Biology ReportsMol Biol Rep 2026; 53: DOI: 10.1007/s11033-026-12478-3 AbstractPulmonary arterial hypertension (PAH) is a complex vascular disease characterized by endothelial dysfunction, pulmonary arterial smooth muscle cell (PASMC) hyperproliferation, metabolic reprogramming, and immune-inflammatory remodeling. These pathological

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Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

The Role of Piezo Ion Channels in Pulmonary Hypertension

Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong DuChildren’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Second Affiliated Hospital and School of Medicine of Zhejiang University. China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70360

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A large animal model of heritable pulmonary arterial hypertension using gene-edited BMPR2 sheep

Sanjeev A. Datar, Nicholas Werry, Austin R. Brown, Devon S. Fitzpatrick, Oluwafemi Falade, Josephine F. Trott, Rachel Hutchings, Elena K. Amin, Jessica M. Morgan, Hythem Nawaytou, Gail H. Deutsch, Eric G. Johnson, Omar A. Gonzales Viera, Thomas F. Bishop, Tara Urbano Beach, Bret R. McNabb, Eric D. Austin, Jeffrey R. Fineman, Alison L. Van EenennaamUniversity

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SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension

Xiao-He Xu, Yi Shen, Min Chen, Yu-Xin Miao, Lin Cheng, Yang-Han-Yue Zhao, Yang Fang, Dai-Ji Jiang, Fang Yu, Yang-Yang He, Zhuo-Yuan Xu, Li-Jun Fu, Li-Wei Wu, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Henan University. Second Affiliated Hospital, Yuying Children’s Hospital, Wenzhou Medical

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