Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Metabolic Deregulation in Pulmonary Hypertension

Rajamma Mathew, Sanda Iacobas, Jing Huang, Dumitru Andrei IacobasNew York Medical College. Rutgers University Biomedical and Health Sciences. Prairie View A&M University.United States Current Issues in Molecular BiologyCurr Issues Mol Biol 2023; 45: 4850-4874DOI: 10.3390/cimb45060309 AbstractThe high morbidity and mortality rate of pulmonary arterial hypertension (PAH) is partially explained by metabolic deregulation. The present study complements […]

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Metabolic reprogramming, oxidative stress, and pulmonary hypertension

Marissa D. Pokharel, David P. Marciano, Panfeng Fu, Maria Clara Franco, Hoshang Unwalla, Kim Tieu, Jeffrey R. Fineman, Ting Wang, Stephen M. BlackFlorida International University.  University of California San Francisco. United States Redox BiologyRedox Biol 2023; DOI: 10.1016/j.redox.2023.102797 AbstractMitochondria are highly dynamic organelles essential for cell metabolism, growth, and function. It is becoming increasingly clear that

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PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells

Yujing Zhao, Juan Wu, Shuai Guan, Ting Xue, Xiaolei Wei, Dawei Cao, Pengzhou Kong, Xinri ZhangThe First Hospital of Shanxi Medical University. The First People’s Hospital of Datong.China International Journal of Chronic Obstructive Pulmonary DiseaseInt J Chron Obstruct Pulmon Dis 2023; 18: 1319-1332DOI: 10.2147/COPD.S406453 AbstractPurpose: Pulmonary artery hypertension (PAH) is a common complication of chronic obstructive pulmonary

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Advances in epigenetic modifications of autophagic process in pulmonary hypertension

Min Mao, Shasha Song, Xin Li, Jiayao Lu, Jie Li, Weifang Zhao, Hanmin Liu, Jingxin Liu, Bin ZengWest China Second University Hospital and Sichuan University. School of Life Sciences of Fudan University. Shenzhen Technology University. Shenzhen Reyson Biotechnology Company. North China Pharmaceutical Company. Hebei Huamin Pharmaceutical Company.China Frontiers in ImmunologyFront Immunol 2023; 14:DOI: 10.3389/fimmu.2023.1206406 AbstractPulmonary hypertension

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Human liver single nuclear RNA sequencing implicates BMPR2, GDF15, arginine, and estrogen in portopulmonary hypertension

Arun Jose, Jean M. Elwing, Steven M. Kawut, Michael W. Pauciulo, Kenneth E. Sherman, William C. Nichols, Michael B. Fallon, Francis X. McCormackUniversity of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center. Perelman School at the University of Pennsylvania. University of Arizona. United States Communications BiologyCommun Biol 2023; 6DOI: 10.1038/s42003-023-05193-3 AbstractPortopulmonary hypertension (PoPH) is

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Microenvironmental regulation of T-cells in pulmonary hypertension

Lydie Plecita-Hlavata, Andrea Brazdova, MonikaKrivonoskova, Cheng-Jun Hu, Tzu Phang, Jan Tauber, Min Li, Hui Zhang, Konrad Hoetzenecker, Slaven Crnkovic, Grazyna Kwapiszewska, Kurt R. StenmarkCzech Academy of Sciences. Charles University. University of Colorado. Medical University of Vienna. Ludwig Boltzmann Institute for Lung Vascular Research. Institute for Lung Health.Czechia, United Stated, Austria and Germany Frontiers in ImmunologyFront

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Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy

Jia-Jie Lin, Rui Chen, Li-Yun Yang, Miao Gong, Mei-Yang Du, Shi-Qing Mu, Ze-An Jiang, Huan-Huan Lia, Yang Yang, Xing-Hui Wang, Si-Fan Wang, Ke-Xin Liu, Shan-Hu Cao, Zhao-Yi Wang, An-Qi Zhao, Shu-Yan Yang, Cheng Lib, Shao-Guang SunHebei Medical University. Guangdong Second Provincial General Hospital. Capital Institute of Pediatrics. China Journal of Advanced ResearchJ Adv Res 2023;

Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy Read More »

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics

Shreya Sangam, Xutong Sun, Tae-Hwi Schwantes-An, Manivannan Yegambaram, Qing Lu, Yinan Shi, Todd Cook, Amanda Fisher, Andrea L. Frump, Anna Coleman, Yanan Sun, Shuxin Liang, Howard Crawford, Katie A. Lutz, Avinash D. Maun, Michael W. Pauciulo, Jason H. Karnes, Ketul R. Chaudhary, Duncan J. Stewart, Paul R. Langlais, Mohit Jain, Mona Alotaibi, Tim Lahm, Yan

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Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

Gayathri Viswananthan, Helene Fradin Kirshner, Nour Nazo, Saba Ali, Asvin Ganapathi, Ian Cumming, Youghua Zhuang, Issac Choi, Anmol Warman, Chanpreet Jassal, Susana Almeida-Peters, John Haney, David Corcoran, Yen-Rei Yu, Sudarshan RajagopalUniversity of Colorado Anschutz Medical Campus. Duke University School of Medicine.United States American Journal of Respiratory and Critical Care MedicineAm J Respir Crit Care Med

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Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis

Jiaquan Zhu, HarukiIde, Yaqin Yana Fu, Anouk-Martine Teichert, Hideyuki Kato, Richard D. Weisel, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneThe Hospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2014; 148: 2550-2557DOI: 10.1016/j.jtcvs.2014.07.050 AbstractObjectives: Pulmonary vein stenosis (PVS) is a relentless disease with

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