Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Single-cell transcriptomics reveals skewed cellular communication and phenotypic shift in pulmonary artery remodeling

Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna KwapiszewskaLudwig Boltzmann Institute for Lung Vascular Research. Medical University of Graz. University of Pennsylvania. Medical University […]

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Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis

Fan Hu, Hanmin Liu, Chuan Wang, Hanwen Li, Lina QiaoWest China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, and West China Hospital of Stomatology. Sichuan University. China Experimental and Therapeutic MedicineExp Ther Med 2022; 23: DOI: 10.3892/etm.2021.11031 AbstractThe biological processes of pulmonary artery vascular smooth muscle cells (PA-SMCs)

Expression of the microRNA-30 family in pulmonary arterial hypertension and the role of microRNA-30d-5p in the regulation of pulmonary arterial smooth muscle cell toxicity and apoptosis Read More »

Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells

Chaoyi Qin, Yiheng Zan, LiangXie, Hanmin LiuWest China Hospital and Sichuan University. China Institute of Women’s and Children’s Health, West China Second University Hospital and Sichuan University. China Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; DOI: 10.3389/fcvm.2022.942251 AbstractObjective: To study the role of ataxia telangiectasia mutated (ATM) in the platelet-derived growth factor (PDGF)-BB-induced proliferation of pulmonary arterial

Ataxia telangiectasia mutated: The potential negative regulator in platelet-derived growth factor-BB promoted proliferation of pulmonary arterial smooth muscle cells Read More »

Dichotomous role of integrin-β5 in lung endothelial cells

Neil Blanchard, Patrick A. Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D. Cool, Rebecca L. Heise, Robert Freishtat, Laszlo FarkasUniversity of Virginia. Ohio State University. Children’s National Health System. University of Colorado. Virginia Commonwealth University.United States Pulmonary CirculationPulm Circ 2022; DOI: 10.1002/pul2.12156 AbstractPulmonary arterial hypertension (PAH) is a progressive,

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Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature

Shelby Thomas, Sathiyanarayanan Manivannan, Vidu Garg, Brenda LillyNationwide Children’s Hospital and Ohio State University.United States Journal of Vascular ResearchJ Vasc Res 2022; 59: 163-175DOI: 10.1159/000522340 AbstractPulmonary arterial hypertension (PAH) is a chronic progressive disease with significant morbidity and mortality. The disease is characterized by vascular remodeling that includes increased muscularization of distal blood vessels and vessel

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Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation

Bernadette Chen, Yi Jin, Caitlyn M. Pool, Yusen Liu, Leif D. NelinNationwide Children’s Hospital and Ohio State University.United States Physiological ReportsPhysiol Rep 2022; DOI: 10.14814/phy2.15342 AbstractThe hallmark of pulmonary hypertension (PH) is vascular remodeling. We have previously shown that human pulmonary microvascular endothelial cells (hPMVEC) respond to hypoxia with epidermal growth factor (EGF) mediated activation of the receptor tyrosine kinase, EGF

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Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease

Bin Wen, Rui Peng, Pengxu Kong, Zefu Li, Yao Liu, Wenbin Ouyang, Yongquan Xie, Xiaopeng Hu, Qiang Wang, Xiangbin PanNational Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Chao-Yang Hospital. Beijing Friendship Hospital. Beijing Anzhen Hospital and Capital Medical University.China American Journal of Respiratory Cell and

Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease Read More »

Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model

Devashis Mukherjee, Ujala Rana, Alison J. Kriegel, Pengyuan Liu, Teresa Michalkiewicz, Girija Ganesh KonduriRainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Medical College of Wisconsin and Children’s Wisconsin.United States Pediatric ResearchPediatr Res 2022; 93: 551-558DOI: 10.1038/s41390-022-02151-3 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) occurs when pulmonary vascular resistance (PVR) fails to

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OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells

Paul Sidlowski, Amanda Czerwinski, Yong Liu, Pengyuan Liu, Ru-Jeng Teng, Suresh Kumar, Clive Wells, Kirkwood Pritchard Jr, Girija G. Konduri, Adeleye J. AfolayanMedical College of Wisconsin. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2022; DOI: 10.1165/rcmb.2022-0186OC AbstractMitochondrial function and metabolic homeostasis are integral to cardiovascular function and influence

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Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension

Michael H. Lee, Linda Sanders, Rahul Kumar, Daniel Henandez-Saavedra, Xin Yun, Joshay A. Ford, Mario J. Perez, Claudia Mickael, Aneta Gandjeva, Daniel E. Koyanagi, Julie W. Harral, David C. Irwin, Biruk Kassa, Robert H. Eckel, Larissa A. Shimoda, Brian B. Graham, Rubin M. TuderUniversity of California, San Francisco. University of Colorado. Johns Hopkins School of

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