Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia

Ryosuke Miura, Atsuto Onoda, Azusa Okamoto, Toshihiko Suzuki, Takahiro Kanzawa, Sakiko Suzuki, Kazuto Ueda, Shinobu Shimizu, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki SatoNagoya University Hospital and Nagoya University Graduate School of Medicine. Sanyo-Onoda City University. Japan Stem Cell Research and TherapyStem Cell Res Ther 2026; 17: DOI: 10.1186/s13287-026-05086-2 AbstractBackground: Neonatal bronchopulmonary dysplasia (BPD) is a lung injury caused […]

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Pilot study to validate endothelium collection from pulmonary artery balloon catheter in children

Maxwell Mathias, Charles Sperrazza, Anas Salkini, Andrew Cave, Courtney T. Griffin, Venkatachalem Sathish, Subhrajit LahiriUniversity of Oklahoma Health College of Medicine. Oklahoma Medical Research Foundation. United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05326-4 AbstractPediatric pulmonary hypertension (PH) has high morbidity and mortality, with an estimated 5-year survival of 75% regardless of underlying cause. Pediatric PH most

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Post-translational modification crosstalk in pulmonary arterial hypertension: mechanisms and therapeutic implications

Jialin Liang, Yuxin Xie, Danyan Su, Yusheng Pangirst Affiliated Hospital of Guangxi Medical University. Guangxi University of Chinese Medicine. China Molecular Biology ReportsMol Biol Rep 2026; 53: DOI: 10.1007/s11033-026-12478-3 AbstractPulmonary arterial hypertension (PAH) is a complex vascular disease characterized by endothelial dysfunction, pulmonary arterial smooth muscle cell (PASMC) hyperproliferation, metabolic reprogramming, and immune-inflammatory remodeling. These pathological

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The Role of Piezo Ion Channels in Pulmonary Hypertension

Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong DuChildren’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Second Affiliated Hospital and School of Medicine of Zhejiang University. China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70360

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Metabolic reprogramming in pulmonary arterial hypertension

Jun-Zhuo Shi, Jing-Song Ye, Xiao-Rui An, Guo Cheng, Xin Fan, Fang-Fang Meng, Ou Yang, Yang-Han-Yue Zhou, Meng-Jie Zhang, Tian-Yi Yuan, Yi Yan, Yang-Yang HeHuaihe Hospital and Henan University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Chinese Academy of Medical Sciences and Peking Union Medical College. Pharmacology and TherapeuticsPharmacol Ther 2026;

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Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare

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Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia

Chantal Gaudet, Kathrine L. Daniel, Sophie Holcik, Ali Hamraghani, Behzad Yeganeh, Robert P JankovChildren’s Hospital of Eastern Ontario. University of Ottawa. Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00090.2026 AbstractBronchopulmonary dysplasia (BPD) is a neonatal lung injury characterized by inflammation, and alveolar and vascular hypoplasia

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KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension

Rehab Alharbi, Merve Keles, Nadia Fernandes, Hannah Maude, Adam Fellows, Richard D. Williams, Chien-Nien Chen, Nathalie Lambie, Nik Matthews, May Al-Sahaf, Sam N. Barnett, Minzhe Guo, Lan Zhao, Allan Lawrie, Jeffrey A. Whitsett, Inês Cebola, Beata Wojciak-StothardImperial College London. University of Hafr Al Batin. Hammersmith Hospital. Cincinnati Children’s Hospital Medical Center and University of Cincinnati

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Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases

You-Yang Zhou, Colin E. EvansAnn and Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. United States International Journal of Molecular SciencesInt J Mol Sci 2026; 27: DOI: 10.3390/ijms27115100 AbstractEndothelial dysfunction is a key characteristic of many diseases, including atherosclerosis, hypertension, heart failure, stroke, cancer, acute respiratory distress syndrome (ARDS), peripheral

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A Biomimetic Miniaturized In Vitro Model to Target Early Markers of Neonatal Pulmonary Vascular Injury

Motaharehsadat Heydarian, Ali Doryab, Juan Henao, Benjamin Schubert, Otmar Schmid, Anne HilgendorffHelmholtz Zentrum München and German Lung Research Center. University of Cambridge. University Hospital Ludwig-Maximilian University. Carl von Ossietzky University.Germany and United Kingdom American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00002.2026 AbstractPulmonary vascular disease (PVD) is

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