Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

In Vitro Models to Study Fibroelastic Remodeling of the Endocardium in Congenital Heart Disease

Julia Gaal, Cindy Zajac, Sophie C. Doettl, Magnus von Piechowski, Kerstin Saraci, Viktoria Weixler, Daniel Diaz-Gil, Pedro J. del Nido, Ingeborg FriehsBoston Children’s Hospital. Charité University. University Hospital of Giessen and Marburg and Justus Liebig University Giessen. Harvard Medical School. United States and Germany Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04503-w AbstractCongenital heart defects (CHD) are

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Development of a Novel Nanoparticle Targeting Endothelial Cells from Patients with Pulmonary Arterial Hypertension

Gabriel Floarea, Nasser Assi, Maytham Ismail, Anderson Gattis, Tadanori Mammoto, Akiko Mammoto, Mathumai KanapathipillaiUniversity of Michigan-Dearborn. Medical College of Wisconsin. United States MoleculesMolecules 2026; 31: DOI: 10.3390/molecules31193511 AbstractPulmonary arterial hypertension (PAH) is a devastating disease driven largely by oxidative stress and inflammation. The pulmonary arterial endothelium plays a key role in PAH pathogenesis. In this

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Imatinib Mesylate and Sirolimus Inhibit Vascular Fibroproliferative Remodeling in Pulmonary Vein Stenosis

Julia Gaal, Sophie C. Doettl, Kerstin Saraci, Cindy Zajac, Alexa von Mueffling, Peter E. Hammer, Magnus von Piechowski, Verena Gebert, Andrei-Antonio M. Caracioni, Daniel Diaz-Gil, Viktoria Weixler, Pedro J. Del Nido, Kathy Jenkins, Ingeborg FriehsBoston Children’s Hospital and Harvard Medical School. German Heart Center of Charité-Universitätsmedizin Berlin.United States and Germany ChildrenChildren 2026; 13: DOI: 10.3390/children13091280

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Energetic Decoding of VSMC Plasticity: Metabolic Reprogramming and Phenotypic Switching

Tingyu Yan, Qian Nie, Bo Xu, Xin Peng, Jiecan ZhuoFirst Affiliated Hospital, Hengyang Medical School and University of South China. China Cardiovascular Drugs and TherapyCardiovasc Drugs Ther 2026; DOI: 10.1007/s10557-026-07959-3 AbstractPhenotypic switching of vascular smooth muscle cells (VSMCs) constitutes a pivotal event in the initiation and progression of various vascular diseases, including vascular calcification, atherosclerosis,

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Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension

Yoshihito Morimoto, Yoshiaki Sato, Katsuhiro Kato, Hidenori Yamamoto, Kentaro Suzuki, Kiyotaka Go, Yoshie Fukasawa, Naoki Ohashi, Yoshiyuki Takahashi, Taichi KatoNagoya University Graduate School of Medicine and Nagoya University Hospital. National Cerebral and Cardiovascular Center. Japan Journal of Molecular and Cellular Cardiology PlusJ Mol Cell Cardiol Plus 2026; 18: DOI: 10.1016/j.jmccpl.2026.100867 AbstractRationale: Although plexiform lesion (PL)

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Alterations of endothelial cell bioenergetics in congenital diaphragmatic hernia

Brian F. Emrick, Irina Zhevlakova, Michael Novotny, Lori Mavrakis, Anny Mulya, Darrell L. Cass, Eiichi Miyasaka, Tatiana V. Byzova, Kewal Asosingh, Serpil C. Erzurum, Jason O. RobertsonCleveland Clinic. Cleveland Clinic Children’s Hospital. University Hospitals Rainbow Babies and Children’s Hospital. United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05447-w AbstractBackground: Pulmonary vascular development in congenital diaphragmatic hernia

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Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia

Ryosuke Miura, Atsuto Onoda, Azusa Okamoto, Toshihiko Suzuki, Takahiro Kanzawa, Sakiko Suzuki, Kazuto Ueda, Shinobu Shimizu, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki SatoNagoya University Hospital and Nagoya University Graduate School of Medicine. Sanyo-Onoda City University. Japan Stem Cell Research and TherapyStem Cell Res Ther 2026; 17: DOI: 10.1186/s13287-026-05086-2 AbstractBackground: Neonatal bronchopulmonary dysplasia (BPD) is a lung injury caused

Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia Read More »

Pilot study to validate endothelium collection from pulmonary artery balloon catheter in children

Maxwell Mathias, Charles Sperrazza, Anas Salkini, Andrew Cave, Courtney T. Griffin, Venkatachalem Sathish, Subhrajit LahiriUniversity of Oklahoma Health College of Medicine. Oklahoma Medical Research Foundation. United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05326-4 AbstractPediatric pulmonary hypertension (PH) has high morbidity and mortality, with an estimated 5-year survival of 75% regardless of underlying cause. Pediatric PH most

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Post-translational modification crosstalk in pulmonary arterial hypertension: mechanisms and therapeutic implications

Jialin Liang, Yuxin Xie, Danyan Su, Yusheng Pangirst Affiliated Hospital of Guangxi Medical University. Guangxi University of Chinese Medicine. China Molecular Biology ReportsMol Biol Rep 2026; 53: DOI: 10.1007/s11033-026-12478-3 AbstractPulmonary arterial hypertension (PAH) is a complex vascular disease characterized by endothelial dysfunction, pulmonary arterial smooth muscle cell (PASMC) hyperproliferation, metabolic reprogramming, and immune-inflammatory remodeling. These pathological

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The Role of Piezo Ion Channels in Pulmonary Hypertension

Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong DuChildren’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Second Affiliated Hospital and School of Medicine of Zhejiang University. China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70360

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