Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension

Hidehiro Suginobe, Hidekazu Ishida, Yoichiro Ishii, Kazutoshi Ueda, Chika 5 Yoshihara, Atsuko Ueyama, Renjie Wang, Hirofumi Tsuru, Kazuhisa Hashimoto, Masaki Hirose, Ryo Ishii, Jun Narita, Yasuji Kitabatake, Keiichi OzonoOsaka University Graduate School of Medicine. Osaka Children’s and Women’s Hospital. Niigata University School of Medicine.Japan Human Molecular GeneticsHum Mol Genet 2023; DOI: 10.1093/hmg/ddad162 AbstractDown syndrome (DS) is […]

Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension Read More »

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis

Hai-Rong Li, Guan-Liang Chen, Xiao-Li Fang, Xing-jiu Cai, Rong-Li Xu, Dong-Dong Li, Zhi-Wei ZhangSouthern Medical University. Hainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University. Guangdong General Hospital.China American Journal of HypertensionAm J Hypertens 2023; DOI: 10.1093/ajh/hpad028 AbstractBackground: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis Read More »

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C.U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwartzHarper Cancer Research Institute. University of Notre Dame. Indiana University School of Medicine. United States Circulation ResearchCirc Res 2023; DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension Read More »

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology

Chien-Nien Chen, Nabil Hajji, Fu-Chiang Yeh, Sunniyat Rahman, Souad Ali, John Wharton, Nicoleta Baxan, Lin Zhao, Chong-Yang Xie, Yi-Guan Chen, Maria G. Frid, Prakash Chelladurai, Soni Savai Pullamsetti, Kurt R. Stenmark, Martin R. Wilkins, Lan ZhaoImperial College London. Tri-Service General Hospital. University of Colorado. University Giessen Lung Centre. Max Planck Institute for Heart and Lung

Restoration of Foxp3+ Regulatory T Cells by HDAC-dependent Epigenetic Modulation Plays a Pivotal Role in Resolving Pulmonary Arterial Hypertension Pathology Read More »

The emerging roles of SUMOylation in pulmonary diseases

Xuyang Zheng, Lingqiao Wang, Zhen Zhang, Huifang TangThe Affiliated Hangzhou First People’s Hospital, Zhejiang Respiratory Drugs Research Laboratory and Zhejiang University School of Medicine. China Molecular MedicineMol Med 2023; 29: DOI: 10.1186/s10020-023-00719-1 AbstractSmall ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair,

The emerging roles of SUMOylation in pulmonary diseases Read More »

Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture

Hanadi Almazroue, Yi Lin, Leif D. Nelin, John C. Barba II, Avante D. Milton, Jennifer K. TrittmannAbigail Wexner Research Institute at Nationwide Children’s Hospital. The Ohio State University College of Medicine.United States American Journal of Physiol Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L360-L367DOI: 10.1152/ajplung.00433.2021 AbstractBronchopulmonary dysplasia (BPD) is the

Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture Read More »

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph KnosallaDeutsches Herzzentrum der Charité. Charité-Universitätsmedizin Berlin. Freie Universität Berlin and Humboldt-Universität zu

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease Read More »

Metabolomic differences in connective tissue disease-associated versus idiopathic pulmonary arterial hypertension in the PVDOMICS cohort

Catherine E. Simpson, Anna R. Hemnes, Megan Griffiths, Gabriele Grunig, W. H. Wison Tang, Joe G. N. Garcia, John Barnard, Suzy A. Comhair, Rachel L. Damico, Stephen C. Mathai, Paul M. Hassoun, the PVDOMICS Study GroupJohns Hopkins University. Vanderbilt University. University of Texas Southwestern Medical Center. New York University Grossman School of Medicine. Cleveland Clinic.

Metabolomic differences in connective tissue disease-associated versus idiopathic pulmonary arterial hypertension in the PVDOMICS cohort Read More »

Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia

Krithika Lingappan, Oluyinka O. Olutoye II, Abiud Cantu, Manuel Eliezer Cantu Gutierrez, Nahir Cortes-Santiago, J. D. Hammond, Jamie Gilley, Joselyn Rojas Quintero, Hui Li, Francesca Polverino, Jason P. Gleghorn, Sundeep G. KeswaniChildren’s Hospital of Philadelphia. Baylor College of Medicine and Texas Children’s Hospital. University of Delaware. United States American Journal of Physiology Lung Cellular and

Molecular insights using spatial transcriptomics of the distal lung in Congenital Diaphragmatic Hernia Read More »

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Min Li, Lydie Plecita-Hlavata, Evgenia Dobrinskikh, B. Alexandre McKeon, Aneta Gandjeva, Suzette Riddle, Aya Laux, Ram Raj Prasad, Sushil Kumar, Rubin M. Tuder, Hui Zhang, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado Denver – Anschutz Medical Campus. Czech Academy of Sciences. United States and Czech Republic American Journal of Respiratory Cell and Molecular BiologyAm J

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension Read More »

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