Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease Archives - Page 8 of 16

Mechanism of pulmonary vein stenosis in infants with normally connected veins

Iran M. Sadr, Puay E. Tan, Mark W. Kieran, Kathy J. JenkinsChildren’s Hospital, Boston.United States American Journal of CardiologyAm J Cardiol 2000; 86: 577-579DOI: 10.1016/s0002-9149(00)01022-5 AbstractWe used microscopy, immunohistochemistry, and cell culture to identify the mechanism of restenosis in 4 infants with isolated pulmonary vein stenosis. Recurrent obstruction appears to be due to myofibroblastic proliferation in […]

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Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

A. Dushani, C. U. Ranasinghe, T. M. Parinda B. Tennakoon, Margaret A. SchwarzBoston Children’s Hospital and Harvard Medical School. Indiana University School of Medicine.United States CellsCells 2024; 13:DOI: 10.3390/cells13030244 AbstractPulmonary Hypertension (PH) is a terminal disease characterized by severe pulmonary vascular remodeling. Unfortunately, targeted therapy to prevent disease progression is limited. Here, the vascular cell populations

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Pathogenesis and Physiologic Mechanisms of Neonatal Pulmonary Hypertension: Preclinical Studies

Karen C. Young, Augusto F. Schmidt, April W. Tan, Lourenco Sbragia, Ahmed Elsaie, Binoy ShivannaUniversity of Miami Miller School of Medicine. Ribeirao Preto Medical School. Ascension Via Christi St. Joseph Hospital and Cairo University. Baylor College of Medicine.United States, Brazil and Egypt Clinics in PerinatologyClin Perinatol 2024; 51: 21-43DOI: 10.1016/j.clp.2023.11.004 AbstractNeonatal pulmonary hypertension (PH) is a

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Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling

Ling Tang, Xiao Zhou, Aili Guo, Lizhang Han, Silin PanJinan Central Hospital. Central Hosptial. Qilu Hospital. Qingdao Women and Children’s Hospital. Shandong University.China Cardiovascular ToxicologyCardiovasc Toxicol 2024;DOI: 10.1007/s12012-023-09822-5 AbstractHigh expression of the zinc finger X-chromosomal protein (ZFX) correlates with proliferation, aggressiveness, and development in many types of cancers. In the current report, we investigated the efficacy

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Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics

Marissa D. Pokharel, Alejandro Garcia-Flores, David Marciano, Maria C. Franco, Jeffrey R. Fineman, Saurabh Aggarwal, Ting Wang, Stephen M. BlackFlorida International University. University of California, San Francisco.United States Redox BiologyRedox Biol 2024; 70:DOI: 10.1016/j.redox.2024.103049 AbstractOnce thought of in terms of bioenergetics, mitochondria are now widely accepted as both the orchestrator of cellular health and the gatekeeper

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Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling

Hyunbum Kim, Yu Liu, Jiwon Kim, Yunhye Kim, Timothy Klouda, Sudeshna Fisch, Seung Han Baek, Tiffany Liu, Suzanne Dahlberg, Cheng-Jun Hu, Wen Tian, Xinguo Jiang, Kosmas Kosmas, Helen A Christou, Benjamin D. Korman, Sara O. Vargas, Joseph C. Wu, Kurt R. Stenmark, Vinicio de Jesus Perez, Mark R. Nicolls,Benjamin A. Raby, Ke Yuan European Molecular

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Biallelic variants in the calpain regulatory subunit CAPNS1 cause pulmonary arterial hypertension

Alex V. Postma, Christina K. Rapp, Katrin Knoflach, Alexander E. Volk, Johannes R. Lemke, Maximilian Ackermann, Nicolas Regamey, Philipp Latzin, Lucas Celant, Samara M. A. Jansen, Harm J. Bogaard, AhoI lgun, Mariëlle Alders, Karin Y. van Spendonck-Zwarts, Danny Jonigk, Christoph Klein, Stefan Gräf, Christian Kubisch, Arjan C. Houweling, Matthias GrieseAmsterdam University Medical Centre. Dr. von

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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension

Yi- Yin Tai, Qiujun Yu, Ying Tang, Wei Sun, Neil J. Kelly, Satoshi Okawa, Jingsi Zhao, Tae- Hwi Schwantes-An, Caroline Lacoux, Stephanie Torrino, Yassmin Al Aaraj, Wadih El Khoury, Vinny Negi, Mingjun Liu, Catherine G. Corey, Frances Belmonte, Sara O. Vargas, Brian Schwartz, Bal Bhat, B. Nelson Chau, Jason H. Karnes, Taijyu Satoh, Robert J.

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