Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Pulmonary artery-targeted low-dose metformin-loaded nanocapsules safely improve pulmonary arterial hypertension in rats

Ayako Chida-Nagai, Naoki Masaki, Hiroki Sato, Tatsuya Kato, Emi Takakuwa, Yoshihiro Matsuno, Atsushi Manabe, Atsuhito TakedaHokkaido University Hospital. Tokyo Women’s Medical University. Tohoku University Graduate School of Medicine. Oita University and Oita University Hospital.Japan Frontiers in PediatricsFront Pediatr 2025; 16: DOI: 10.3389/fphar.2025.1577570 AbstractIntroduction: Pulmonary arterial hypertension (PAH) remains a challenge to tackle despite various available medications. Metformin, […]

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Cyclopamine Attenuates Pulmonary Arterial Hypertension Development: Implications of Hedgehog Signaling Involvement for the Pathophysiology

Makito Sakurai, Susumu Hosakawa, Yohei Yamaguchi, Susumu Kirimura, Kensuke Ihara, Kenichi Ohashi, Tetsushi Furukawa, Tetsuo Sasano, Kenichi Kashimada, Taku IshiiInstitute of Science Tokyo. Japanese Red Cross Musashino Hospital.  National Center for Child Health and Development. Japan Federation of American Societies for Experimental Biology JournalFASEB J 2025; 39: DOI: 10.1096/fj.202403350R AbstractPulmonary arterial hypertension (PAH) is one of

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Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Jason T. Boehme, Sanjeev A. Datar, Xutong Sun, Wenhui Gong, Qing Lu, Jamie Soto, Michael A. Smith, Alejandro E. Garcia-Flores, Gary W. Raff, TingWang, Emin Maltepe, Stephen M. Black, Jeffrey R. FinemanUniversity of California San Francisco. Florida International University. University of California Davis. United States Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-99062-0 AbstractIn patients with congenital

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Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells

Manivannan Yegambaram, Marissa D. Pokharel, Xutong Sun, Qing Lu, Jamie Soto, Saurabh Aggarwal, Emin Maltepe, Jeffery R. Fineman, Ting Wang, Stephen M. BlackFlorida International University. University of California San Francisco. United States International Journal of Molecular SciencesInt J Mol Sci 2025; 26: DOI: 10.3390/ijms26083815 AbstractIt is well-established that mitochondrial dysfunction plays a critical role in the

Restoration of pp60Src Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells Read More »

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

Decreased endothelial micro-RNA-30b-5p impairs angiogenesis in fetal lambs with persistent pulmonary hypertension

Sunil K. Sati, Ujala Rana, Chintamani Joshi, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04098-7 AbstractBackground: Impaired angiogenesis contributes to increased pulmonary vascular resistance in persistent pulmonary hypertension of the newborn (PPHN). Notch signaling, critical to lung angiogenesis, is modulated by micro-RNAs (miR). RNA sequencing of pulmonary arterial endothelial cells

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Female Fibroblast Activation Is Estrogen-Mediated in Sex-Specific 3D-Bioprinted Pulmonary Artery Adventitia Models

Mikala C. Mueller, Rachel Blomberg, Alicia E. Tanneberger, Duncan Davis-Hall, Keith B. Neeves, Chelsea M. MaginUniversity of Colorado. United States American Chemical Society Biomaterials Science and EngineeringACS Biomater Sci Eng 2025; DOI: 10.1021/acsbiomaterials.5c00123 AbstractPulmonary arterial hypertension (PAH) is a form of pulmonary vascular disease characterized by scarring of the small blood vessels that results in reduced

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MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb

Xiang-Qun Hu, Rui Song, Chiranjib Dasgupta, Stephen Twum-Barimah, Taiming Liu, Abu Ahmed, Shawn F. Hanson, Lubo Zhang, Arlin B. BloodLoma Linda University School of Medicine.United States HypertensionHypertension 2025; DOI: 10.1161/HYPERTENSIONAHA.124.23061 AbstractBackground: Pulmonary hypertension of the newborn is a life-threatening disorder characterized by elevated pulmonary vascular resistance due to maladaptation of the pulmonary circulation after birth. The etiology

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Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1-7) Alone is Insufficient

James West, Megha Talati, Erica Carrier, Anandharajan Rathinasabapathy, Ibragim Gaidarov, Benjamin Vigl, Ying Cai, Hongpeng Jia, Tom Blackwell, Santhi Gladson, Christie Moore, Sheila Shay, Ethan Sevier, Anna HemnesVanderbilt University Medical Center. Eurofins Beacon Discovery. Alterras Therapeutics. Johns Hopkins University School of Medicine.United States and Austria Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70083 AbstractACE2 has shown effectiveness

Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1-7) Alone is Insufficient Read More »

Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension

Rebecca L. Harper, Xin Zhou, David P. Marciano, Aiqin Cao, Lingli Wang, Guibin Chen, Mir S. Adil, Wenyu Zhou, Peter Maguire, Shanthi Deivanayagam, Quan Yu, Vignesh Viswanathan, Dan Yang, Marcy Martin, Sarasa Isobe, Shoichiro Otsuki, Jordan Burgess, Audrey Inglis, Devon Kelley, Patricia A. del Rosario, Andrew Hsi, Francois Haddad, Roham T. Zamanian, Manfred Boehm, Michael

Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension Read More »

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