Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao1, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene RabinovitchLucile Packard Children’s Hospital and Stanford University School of Medicine. University Medical Center […]

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Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III

Manivannan Yegambaram, Xutong Sun, Qing Lu, Yan Jin, Wojciech Ornatowski, Jamie Soto, Saurabh Aggarwal, Ting Wang, Kim Tieu, Haiwei Gu, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of Arizona. University of California San Francisco.United States Free Radical Biology and MedicineFree Radic Biol Med 2023; DOI: 10.1016/j.freeradbiomed.2023.11.008 AbstractObjective: Pulmonary hypertension (PH) is a progressive disease with

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Mesenchymal stromal/stem cells and bronchopulmonary dysplasia

Shuqing Zhang, Cassidy Mulder, Suzette Riddle, Rui Song, Dongmei YueShengjing Hospital and China Medical University. Liberty University College of Osteopathic Medicine. University of Colorado Anschutz Medical Campus. Loma Linda University School of Medicine. China and Uniteds States Frontiers in Cell and Developmental BiologyFront Cell Dev Biol 2023; DOI: 10.3389/fcell.2023.1247339 AbstractBronchopulmonary dysplasia (BPD) is a common complication

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Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

Selena Ferrian, Aiqin Cao, Erin McCaffrey, Toshie Saito, Noah F. Greenwald, Mark R. Nichols, Trevor Bruce, Roham T. Zamanian, Patricia Del Rosario, Marlene Rabinovitch, Michael AngeloStanford University School of Medicine. United States American Journal of Respiratory and Critical Care MedicineAm J Respir Crit Care Med 2023; DOI: 10.1164/rccm.202209-1761OC AbstractRationale: Elucidating the immune landscape within and surrounding pulmonary

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Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study

Jay I. LaBourene, John G. Coles, Dorothy J. Johnson, Arun Mehra, Fred W. Keeley, Marlene RabinovitchHospital for Sick Children.Canada Circulation ResearchCirc Res 1990; 66: 438-456DOI: 10.1161/01.res.66.2.438 AbstractWe created an animal model to understand better the pathogenesis and underlying mechanism of progressive central pulmonary venous (PV) obstruction, a condition not amenable to current therapy. Twenty piglets underwent

Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study Read More »

Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea

Yuing-Che Chen, Po-Yuan Hsu, Mao-Chang Su, Ung-Lung Chen, Ya-Ting Chang, Chien-Hung Chin, I.-Chun Lin, Yu-Mu Chen, Ting-Ya Wang, Yong-Yong Lin, Chiu-Ping Lee, Meng-Chih Lin, Chang-Chun HsiaoKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine. Chang Gung University of Science and Technology. Taiwan Molecular and Cellular BiochemistryMol Cell Biochem 2023; DOI: 10.1007/s11010-023-04880-3 AbstractAltered expressions

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Advances in the research of sulfur dioxide and pulmonary hypertension

Xin Liu, He Zhou, Hongsheng Zhang, Hongfang Jin, Yan HeBeijing Anzhen Hospital and Capital Medical University. Tulane University School of Medicine. Peking University First Hospital and Peking University.China and United States Frontiers in PharmacologyFront Pharmacol 2023; 14:DOI: 10.3389/fphar.2023.1282403 AbstractPulmonary hypertension (PH) is a fatal disease caused by progressive pulmonary vascular remodeling (PVR). Currently, the mechanisms underlying

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Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly

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Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension

Hidehiro Suginobe, Hidekazu Ishida, Yoichiro Ishii, Kazutoshi Ueda, Chika 5 Yoshihara, Atsuko Ueyama, Renjie Wang, Hirofumi Tsuru, Kazuhisa Hashimoto, Masaki Hirose, Ryo Ishii, Jun Narita, Yasuji Kitabatake, Keiichi OzonoOsaka University Graduate School of Medicine. Osaka Children’s and Women’s Hospital. Niigata University School of Medicine.Japan Human Molecular GeneticsHum Mol Genet 2023; DOI: 10.1093/hmg/ddad162 AbstractDown syndrome (DS) is

Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension Read More »

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis

Hai-Rong Li, Guan-Liang Chen, Xiao-Li Fang, Xing-jiu Cai, Rong-Li Xu, Dong-Dong Li, Zhi-Wei ZhangSouthern Medical University. Hainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University. Guangdong General Hospital.China American Journal of HypertensionAm J Hypertens 2023; DOI: 10.1093/ajh/hpad028 AbstractBackground: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis Read More »

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