Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease Archives - Page 7 of 16

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. StenmarkUniversity of Colorado School of Medicine. University of California San Francisco. Zuckerberg San Francisco General Hospital.United States Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1372959 AbstractIntroduction: Hypoxia […]

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The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

Xuran Chu, Vahid Kheirollahi, Arun Lingampally, Prakash Chelladurai, Chanil Valasarajan, Ana Ivonne Vasquez-Armendariz, Stefan Hadzic, Ali Khadim, Oleg Pak, Stefano Rivetti, Jochen Wilhelm, Marek Bartkuhn, Slaven Crnkovic, Alena Moiseenko, Mohika Heiner, Simone Kraut, Leila Sotoodeh, Janine Koepke, Guilherme Valente, Clemens Ruppert, Thomas Braun, Christos SamakovlisIoannis Alexopoulos, MAria Looso, Cho-Mong Chao, Susanne Herold, Werner Seeger, Grazyna

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Digital Spatial Profiling Identifies Distinct Molecular Signatures of Vascular Lesions in Pulmonary Arterial Hypertension

Rubin M. Tuder, Aneta Gandjeva, Sarah Williams, Sushil Kumar, Vitaly O. Kheyfets, Kyle Matthew Hatton-Jones, Jacqueline R. Starr, Jeong Yun, Jason Hong, Nicholas R. West, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus School of Medicine. University of Colorado. Griffith University. Brigham and Women’s Hospital and Harvard Medical School. University of California, Los Angeles.United States

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Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells

Chanéle Cyr-Depauw, David P. Cook, Ivana Mizik, Flore Legase, Arul Vadivel, Laurent Renesme, Yupu Deng, Shumei Zhong, Pauline Bardin, Liqun Xu, Marius A. Möbius, Jenny Marzahn, Daniel Freund, Duncan J. Stewart, Barbara C. Vanderhyden, Mario Rüdiger, Bernard ThébaudOttawa Hospital Research Institute. University of Ottawa. Universitätsklinikum Carl Gustav Carus. Technische Universität Dresden. Children’s Hospital of Eastern

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c-Myc Drives inflammation of the maternal-fetal interface, and neonatal lung remodeling induced by intra-amniotic inflammation

April W. Tan, Xiaoying Tong, Silvia Alvarez-Cubela, Pingping Chen, Aline Guimarães Santana, Alejo A. Morales, Runxia Tian, Rae Infante, Vanessa Nunes de Paiva, Shathiyah Kulandavelu, Merline Benny, Juan Dominguez-Bendala, Shu Wu, Karen C. Young, Claudia O. Rodrigues, Augusto F. SchmidtUniversity of Miami Miller School of Medicine and Holtz Children’s Hospital. Florida Atlantic University Charles E.

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RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension

Zhe Wang, Yi-Xuan Zhang, Jun-Zhuo Shi, Yi Yan, Lu-Ling Zhao, Jie-Jian Kou, Yang-Yang He, Xin-Mei Xie, Si-Jin Zhang, Xiao-Bin PangHuaihe Hospital of Henan University. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Guangdong Provincial People’s Hospital and Southern Medical University.China Hypertension ResearchHypertens Res 2024; DOI: 10.1038/s41440-024-01607-9 Abstractm6A (N6‑methyladenosine)

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Increased Elastase and Matrix Metalloproteinase Levels in the Pulmonary Arteries of Infants With Congenital Diaphragmatic Hernia

Jui-Hsia Hung, Stéphanie Langlois, Meagen Weibe, Benjamin Wild, Jessica Barré-Dunn, Kyle N. CowanUniversity of Ottawa and Children’s Hospital of Eastern Ontario. Canada Journal of Pediatric SurgeryJ Pediatr Surg 2024;DOI: 10.1016/j.jpedsurg.2024.01.028 AbstractBackground: Pulmonary vascular disease (PVD) complicated with pulmonary hypertension (PH) is a leading cause of mortality in congenital diaphragmatic hernia (CDH). Unfortunately, CDH patients are often resistant

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