Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension

Yi‑Chia Wu, Wei‑Ting Wang, Ming‑Chun Yang, Yu‑Tsun Su, Jwu‑Lai Yeh, Jong‑Hau Hsu, Jiunn‑Ren WuKaohsiung Medical University Hospital and Kaohsiung Medical University. Kaohsiung Municipal Ta-Tung Hospital. E-Da Hospital and I-Shou University.Taiwan Biological ResearchBiol Res 2023; DOI: 10.1186/s40659-023-00480-z AbstractBackground: Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along […]

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Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

A. Dushani C. U. Ranasinghe, Maggie Holohan, Kalyn M. Borger, Deborah L. Donahue, Rafael D. Kuc, Martin Gerig, Andrew Kim, Victoria A. Ploplis, Francis J. Castellino, Margaret A. SchwarzHarper Cancer Research Institute and University of Notre Dame.United States Circulation ResearchCirc Res 2023; 133: 704-719DOI: 10.1161/CIRCRESAHA.123.322740 AbstractBackground: Epigenetic regulation of vascular remodeling in pulmonary hypertension (PH) is poorly

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Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Sarasa Isobe, Ramesh V. Nair, Helen Y. Kang, Lingli Wang, Jan-Renier Moonen, Tsutomu Shinohara, Aiqin Cao1, Shalina Taylor, Shoichiro Otsuki, David P. Marciano, Rebecca L. Harper, Mir S. Adil, Chongyang Zhang, Mauro Lago-Docampo, Jakob Körbelin, Jesse M. Engreitz, Michael P. Snyder, Marlene RabinovitchLucile Packard Children’s Hospital and Stanford University School of Medicine. University Medical Center

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Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III

Manivannan Yegambaram, Xutong Sun, Qing Lu, Yan Jin, Wojciech Ornatowski, Jamie Soto, Saurabh Aggarwal, Ting Wang, Kim Tieu, Haiwei Gu, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of Arizona. University of California San Francisco.United States Free Radical Biology and MedicineFree Radic Biol Med 2023; DOI: 10.1016/j.freeradbiomed.2023.11.008 AbstractObjective: Pulmonary hypertension (PH) is a progressive disease with

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Mesenchymal stromal/stem cells and bronchopulmonary dysplasia

Shuqing Zhang, Cassidy Mulder, Suzette Riddle, Rui Song, Dongmei YueShengjing Hospital and China Medical University. Liberty University College of Osteopathic Medicine. University of Colorado Anschutz Medical Campus. Loma Linda University School of Medicine. China and Uniteds States Frontiers in Cell and Developmental BiologyFront Cell Dev Biol 2023; DOI: 10.3389/fcell.2023.1247339 AbstractBronchopulmonary dysplasia (BPD) is a common complication

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Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

Selena Ferrian, Aiqin Cao, Erin McCaffrey, Toshie Saito, Noah F. Greenwald, Mark R. Nichols, Trevor Bruce, Roham T. Zamanian, Patricia Del Rosario, Marlene Rabinovitch, Michael AngeloStanford University School of Medicine. United States American Journal of Respiratory and Critical Care MedicineAm J Respir Crit Care Med 2023; DOI: 10.1164/rccm.202209-1761OC AbstractRationale: Elucidating the immune landscape within and surrounding pulmonary

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Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study

Jay I. LaBourene, John G. Coles, Dorothy J. Johnson, Arun Mehra, Fred W. Keeley, Marlene RabinovitchHospital for Sick Children.Canada Circulation ResearchCirc Res 1990; 66: 438-456DOI: 10.1161/01.res.66.2.438 AbstractWe created an animal model to understand better the pathogenesis and underlying mechanism of progressive central pulmonary venous (PV) obstruction, a condition not amenable to current therapy. Twenty piglets underwent

Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study Read More »

Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea

Yuing-Che Chen, Po-Yuan Hsu, Mao-Chang Su, Ung-Lung Chen, Ya-Ting Chang, Chien-Hung Chin, I.-Chun Lin, Yu-Mu Chen, Ting-Ya Wang, Yong-Yong Lin, Chiu-Ping Lee, Meng-Chih Lin, Chang-Chun HsiaoKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine. Chang Gung University of Science and Technology. Taiwan Molecular and Cellular BiochemistryMol Cell Biochem 2023; DOI: 10.1007/s11010-023-04880-3 AbstractAltered expressions

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Advances in the research of sulfur dioxide and pulmonary hypertension

Xin Liu, He Zhou, Hongsheng Zhang, Hongfang Jin, Yan HeBeijing Anzhen Hospital and Capital Medical University. Tulane University School of Medicine. Peking University First Hospital and Peking University.China and United States Frontiers in PharmacologyFront Pharmacol 2023; 14:DOI: 10.3389/fphar.2023.1282403 AbstractPulmonary hypertension (PH) is a fatal disease caused by progressive pulmonary vascular remodeling (PVR). Currently, the mechanisms underlying

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Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly

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