Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu ZhouSeventh Medical Center of the PLA General Hospital. Southern Medical University. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02945-5 AbstractBackground: Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev […]

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension Read More »

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Shuibang Wang, Keytam S. Awad, Li-Yuan Chen, Mohammad A. H. Siddique, Gabriela A. Ferreyra, Caroline L. Wang. Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, You-Yang Zhao, Jason M. Elinoff, Robert L. DannerNational Institutes of Health Clinical Center. National Heart Lung and Blood Institute. Northwestern University.United States American Journal of Physiology Lung Cellular and

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α Read More »

Adenylyl Cyclase Isoform 6 in the Pulmonary Artery Is Inhibited by Hypoxia via Cysteine Nitrosylation

Saeid Maghsoudi, Vikram Bhatia, Martha Hinton, Nisha Singh, Modh Wasif Khan, Prashen Chelikani, Shyamala, DakshinamurtiUniversity of Manitoba Faculty of Health Sciences. University of Manitoba Children’s Hospital Research Institute of Manitoba. University of Manitoba College of Dentistry. Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2024; DOI: 10.1165/rcmb.2023-0447OC AbstractPersistent pulmonary hypertension

Adenylyl Cyclase Isoform 6 in the Pulmonary Artery Is Inhibited by Hypoxia via Cysteine Nitrosylation Read More »

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway

Bin Liu, Dan Yi, Xiaomei Xia, Karina Ramirez, Hanqiu Zhao, Yanhong Cao, Ankit Tripathi, Ryan Dong, Anton Gao, Hongxu Ding, Shenfeng Qiu, Vladimir V. Kalinichenko,You-Yang Zhao, Michael B. Fallon, Zhiyu DaiUniversity of Arizona. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United States CirculationCirculation 2024; 150: 414-417DOI: 10.1161/CIRCULATIONAHA.123.067981 AbstractAbstract Not Available CategoryVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseAnimal Models of Pulmonary Vascular Disease and TherapyPulmonary Vascular Pathology Age Focus: No

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway Read More »

Lipocalin-2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension

Yao Yao, Xin Bin, Yanxuan Xu, Shaowan Chen, Si Chen, Xiang-Ling Yuan, Yingjie Cao, Tsz Kin NgBeijing Children’s Hospital, Capital Medical University and National Center for Children’s Health. Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Children’s Hospital and Capital Medical University. Chinese Academy of

Lipocalin-2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension Read More »

Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation

Alban Todesco, Julien Grynblat, Kouamé Kan Firmin Akoumia, Damien Bonnet, Pedro Mendes‐Ferreira, Stéphane Morisset, Denis Chemla, Marilyne Levy, Mathilde Méot, Sophie‐Guiti Malekzadeh‐Milani, Birger Tielemans, Benoit Decante, Carine Vastel‐Amzallag, Paul Habert, Maria‐Rosa Ghigna, Marc Humbert, David Montani, David Boulate, Frédéric PerrosNorth Hospital Aix Marseille University, Assistance Publique-Hôpitaux de Marseille. INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis. Hôpital Necker-Enfants malades AP-HP Université de Paris Cité. Le Kremlin-Bicêtre Université Paris-Saclay. Faculty of Medicine of

Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation Read More »

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey, Sarah Rieck, Judith Alenfelder, Gabriele M. KUonig, Alexander Pfeifer, Evi Kostenis, Anna Klinke, Bernd K. Fleischmann, Daniela WenzelUniversity Hospital of the Ruhr University of Bochum and Ruhr University of Bochum. University Hospital of Nottingham. Massachusetts General Hospital and Harvard Medical School. University of

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension Read More »

Post-treatment with Resolvin D1 attenuates pulmonary hypertension by inhibiting endothelial-to-mesenchymal transition

Xinyu Lia, Hui Li, Bo Feng, Xiaoyan Chen, Ting Chen, Jiafei Lu, Huating Xie, Nana Su, Houlin Chen, Chenghao Lou, Runxin Zhuang, Xi Chen, Shengwei Jin, Yu HaoSecond Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Ruijin Hospital and Shanghai Jiao Tong University School of Medicine. China Biomedicine and PharmacotherapyBiomed Pharmacother 2024; DOI: 10.1016/j.biopha.2024.117023

Post-treatment with Resolvin D1 attenuates pulmonary hypertension by inhibiting endothelial-to-mesenchymal transition Read More »

Endothelial-to-Mesenchymal Transition in an Hereditary Hemorrhagic Telangiectasia-like Pediatric Case of Multiple Pulmonary Arteriovenous Malformations

Laura Lorente-Herraiz, Angel M. Cuesta, Lucía Recio-Poveda, Luisa M. Botella, Virginia AlbiñanaCentro de Investigaciones Biológicas Margarita Salas, CIB-CSIC. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER). Universidad Complutense de Madrid. Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC).Spain International Journal of Molecular SciencesInt J Mol Sci 2024; 25: DOI: 10.3390/ijms25116163 AbstractPulmonary arteriovenous

Endothelial-to-Mesenchymal Transition in an Hereditary Hemorrhagic Telangiectasia-like Pediatric Case of Multiple Pulmonary Arteriovenous Malformations Read More »

Fibroblasts in Pulmonary Hypertension: Roles and Molecular Mechanisms

Hui Zhang, Min Li, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado School of Medicine and School of Dental Medicine.United States CellsCells 2024; 13: DOI: 10.3390/cells13110914 AbstractFibroblasts, among the most prevalent and widely distributed cell types in the human body, play a crucial role in defining tissue structure. They do this by depositing and remodeling extracellular matrixes

Fibroblasts in Pulmonary Hypertension: Roles and Molecular Mechanisms Read More »

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