Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Aberrant PGC-1α signaling in a lamb model of persistent pulmonary hypertension of the newborn

Emily A. Mooers, Hollis M. Johnson, Teresa Michalkiewicz, Ujala Rana, Chintamani Joshi, Adeleye J. Afolayan, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03223-2 AbstractBackground: Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by elevated pulmonary vascular resistance (PVR), resulting in hypoxemia. Impaired angiogenesis contributes to high PVR. Pulmonary artery […]

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The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives

Yunjia Song, Shuo Cao, Xutao Sun, Guozhen ChenHeilongjiang University of Chinese Medicine. The Affiliated Yantai Yuhuangding Hospital.China Mammalian GenomeMamm Genome 2024; DOI: 10.1007/s00335-024-10043-6 AbstractHydrogen sulfide (H2S) is recognized as the third gasotransmitter, after nitric oxide (NO) and carbon monoxide (CO). It is known for its cardioprotective properties, including the relaxation of blood vessels, promotion of angiogenesis,

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A neonatal rat model of pulmonary vein stenosis

Debao Li, Lisheng Qiu, Haifa Hong, Hao Chen, Peibin Zhao, Yingying Xiao, Hao Zhang, Qi Sun, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University. Second Affiliated Hospital and Yuying Children’s Hospital and Wenzhou Medical University.China Cell and BioscienceCell Biosci 2023; 13:DOI: 10.1186/s13578-023-01058-8 AbstractObjectives: Pulmonary vein stenosis (PVS), one of the most challenging clinical problems in

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Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University. United

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Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

Mikala C. Mueller, Yanmei Du, Lori A. Walker, Chelsea M. MaginUniversity of Colorado, Anschutz Medical Campus.United States Matrix Biology PlusMatrix Biol Plus 2024; DOI: 10.1016/j.mbplus.2024.100145 AbstractRespiratory diseases like pulmonary arterial hypertension (PAH) frequently exhibit sexual dimorphism. Female PAH patients are more susceptible to the disease but have increased survival rates. This phenomenon is known as the

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Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Haiyang Tang, Akash Gupta, Seth A. Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R. Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A. Warfel, Louise Hecker, Sumegha Mitra, Anna W. Coleman, Katie A. Lutz, Michael W. Pauciulo, Yen-Chun Lai, Ali Javaheri,

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Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. StenmarkUniversity of Colorado School of Medicine. University of California San Francisco. Zuckerberg San Francisco General Hospital.United States Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1372959 AbstractIntroduction: Hypoxia

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Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells

Yi-Ching Liu, Yu-Hsin Tseng, Yu-Hsin Kuan, Lin-Yen Wang, Shang-En Huang, Siao-Ping Tsai, Iwu-Lai Yeh, Jong-Hau HsuKaohsiung Medical University Hospital and Kaohsiung Medical University. E-Da Hospital and I-Shou University. National Sun Yat-sen University. Chia Nan University of Pharmacy and Science. Taiwan Kaohsiung Journal of Medical ScienceKaohsiung J Med Sci 2024; DOI: 10.1002/kjm2.12835 AbstractPulmonary vascular remodeling is a

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The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

Xuran Chu, Vahid Kheirollahi, Arun Lingampally, Prakash Chelladurai, Chanil Valasarajan, Ana Ivonne Vasquez-Armendariz, Stefan Hadzic, Ali Khadim, Oleg Pak, Stefano Rivetti, Jochen Wilhelm, Marek Bartkuhn, Slaven Crnkovic, Alena Moiseenko, Mohika Heiner, Simone Kraut, Leila Sotoodeh, Janine Koepke, Guilherme Valente, Clemens Ruppert, Thomas Braun, Christos SamakovlisIoannis Alexopoulos, MAria Looso, Cho-Mong Chao, Susanne Herold, Werner Seeger, Grazyna

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