Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism

Paulina N. Krause, Gabrielle McGeorge, Jennifer L. McPeek, Sidra Khalid, Leif D. Nelin, Yusen Liu, Bernadette ChenNationwide Children’s Hospital and Ohio State University College of Medicine.United States Physiological ReportsPhysiol Rep 2024; 12: DOI: 10.14814/phy2.70089 AbstractA role for metabolically active adipose tissue in pulmonary hypertension (PH) pathogenesis is emerging. Alterations in cellular metabolism in metabolic syndrome are triggers of PH-related vascular dysfunction. Metabolic reprogramming […]

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Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations

Yang Yang, Xiuju Wu, Yan Zhao, Daoqin Zhang, Li Zhang, Xinjiang Cai, Jaden Ji, Zheng Jing, Kristina I. Boström, Yucheng YaoDavid Geffen School of Medicine and University of California. Stanford University.United States CirculationCirculation 2024; DOI: 10.1161/CIRCULATIONAHA.124.070925 AbstractBackground: Arteriovenous malformations (AVMs) are characteristic of hereditary hemorrhagic telangiectasia. Loss-of-function mutations in the activin receptor-like kinase 1 (Alk1) are linked

Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations Read More »

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension

Dong Hun Lee, Andrew J. Jang, Minseong Kim, Sarah S. Chang, Raham Lee, Juyoung Kim, Jing Ma, Michael J. Passineau, Raymond L. Benza, Harry Karmouty‐Quintana, Benjamin T. Kopp Roy L. Sutliff, Wilbur A. Lam, C. Michael Hart, Changwon Park, Bum‐Yong KangEmory University School of Medicine. Chonnam National University. Louisiana State University Health Science Center. Atlanta

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A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

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The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status

Xutong Sun, Santiago Moreno, Manivannan Yegambaram, Qing Lu, Marissa D. Pokharel, Jason T. Boehme, Sanjeev A. Datar, Sayrabh Aggarwal, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of California San Francisco. United States Nitric OxideNitric Oxide 2024; DOI: 10.1016/j.niox.2024.09.009 AbstractPreviously, we have shown that endothelial nitric-oxide synthase (eNOS) dimer levels directly correlate with

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Inhibition of DLL4/Notch Signaling Pathway Promotes M2 Polarization and Cell Proliferation in Pulmonary Arterial Hypertension

Guangxing Tan, Chenxia Juan, Yan Mao, Gang Xue, Zhuyuan FangJiangsu Province Hospital of Chinese Medicine, Wuxi Hospital of Traditional Chinese Medicine and Affiliated Hospital of Nanjing University of Chinese Medicine. Yangzhou Hospital of Traditional Chinese Medicine. China American Chemical Society OmegaACS Omega 2024; 9: 37923-37933DOI: 10.1021/acsomega.4c04307 AbstractIn this study, we conducted a comprehensive analysis to identify

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Understanding how methyltransferase-like 3 functions in lung diseases: From pathogenesis to clinical application

Deshuang Zhang, Zhixian Gou, Yi Qu, Xiaojuan SuWest China Second University Hospital and Sichuan University. School of Clinical Medicine and First Affiliated Hospital of Chengdu Medical College. China Biomedicine and PharmacotherapyBiomed Pharmacother 2024; DOI: 10.1016/j.biopha.2024.117421 AbstractLung diseases have complex pathogenesis and treatment challenges, showing an obvious increase in the rate of diagnosis and death every year.

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Unraveling the Mfn2-Warburg effect nexus: a therapeutic strategy to combat pulmonary arterial hypertension arising from catch-up growth after IUGR

Lingling Yan, Xiaofei Luo, Chengcheng Hang, YuWang, Ziming Zhang, Shanshan Xu, Lizhong DuChildren’s Hospital and First Affiliated Hospital of Zhejiang University School of Medicine. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02957-1 AbstractBackground: The interplay between intrauterine and early postnatal environments has been associated with an increased risk of cardiovascular diseases in adulthood, including pulmonary arterial hypertension

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Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension

Claudia Mickael, Linda A. Sanders, Michael H. Lee, Rahul Kumar, Dara Fonseca- Balladares, Aneta Gandjeva, Kelly Cautivo-Reyes, Biruk Kassa, Sushil Kumar, David Irwin, Delaney Swindle, Tzu Phang, Robert S. Stearman, Ari B. Molofsky, Amy S. MxKee, Kurt R. Stenmark, Brian B. Graham, Rubin M. TuderUniversity of Colorado. University of California San Francisco. Zuckerberg San Francisco

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Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Christopher J. Rhodes, Adam Brownstein, Lloyd L. Liang, Laila Aryan, Min Li, Arjun Vadgama, Zeyneb Kurt, Tae-Hwi Schwantes-An, Elizabeth A. Mickler, Stefan Gräf, Mélanie Eyries, Katie A. Lutz, Michael W. Pauciulo, Richard C. Trembath, Frédéric Perros, David Montani, Nicholas W. Morrell, Florent Soubrier, Martin R.

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