Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Unraveling the Mfn2-Warburg effect nexus: a therapeutic strategy to combat pulmonary arterial hypertension arising from catch-up growth after IUGR

Lingling Yan, Xiaofei Luo, Chengcheng Hang, YuWang, Ziming Zhang, Shanshan Xu, Lizhong DuChildren’s Hospital and First Affiliated Hospital of Zhejiang University School of Medicine. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02957-1 AbstractBackground: The interplay between intrauterine and early postnatal environments has been associated with an increased risk of cardiovascular diseases in adulthood, including pulmonary arterial hypertension […]

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Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension

Claudia Mickael, Linda A. Sanders, Michael H. Lee, Rahul Kumar, Dara Fonseca- Balladares, Aneta Gandjeva, Kelly Cautivo-Reyes, Biruk Kassa, Sushil Kumar, David Irwin, Delaney Swindle, Tzu Phang, Robert S. Stearman, Ari B. Molofsky, Amy S. MxKee, Kurt R. Stenmark, Brian B. Graham, Rubin M. TuderUniversity of Colorado. University of California San Francisco. Zuckerberg San Francisco

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Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension

Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Christopher J. Rhodes, Adam Brownstein, Lloyd L. Liang, Laila Aryan, Min Li, Arjun Vadgama, Zeyneb Kurt, Tae-Hwi Schwantes-An, Elizabeth A. Mickler, Stefan Gräf, Mélanie Eyries, Katie A. Lutz, Michael W. Pauciulo, Richard C. Trembath, Frédéric Perros, David Montani, Nicholas W. Morrell, Florent Soubrier, Martin R.

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Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension

Qiang Meng, Linhong Song, Hui Wang, Gang Wang, Gengxu ZhouSeventh Medical Center of the PLA General Hospital. Southern Medical University. China Respiratory ResearchRespir Res 2024; 25: DOI: 10.1186/s12931-024-02945-5 AbstractBackground: Pulmonary hypertension (PH) is a long-term disease that impacts approximately 1% of the world’s population. Currently, levosimendan (Lev) is proposed for PH treatment. However, the mechanism of Lev

Levosimendan mediates the BMP/Smad axis through upregulation of circUSP34-targeted miR-1298 to alleviate pulmonary hypertension Read More »

Endothelial PHD2 deficiency induces apoptosis resistance and inflammation via AKT activation and AIP1 loss independent of HIF2α

Shuibang Wang, Keytam S. Awad, Li-Yuan Chen, Mohammad A. H. Siddique, Gabriela A. Ferreyra, Caroline L. Wang. Thea Joseph, Zu-Xi Yu, Kazuyo Takeda, Cumhur Y. Demirkale, You-Yang Zhao, Jason M. Elinoff, Robert L. DannerNational Institutes of Health Clinical Center. National Heart Lung and Blood Institute. Northwestern University.United States American Journal of Physiology Lung Cellular and

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Adenylyl Cyclase Isoform 6 in the Pulmonary Artery Is Inhibited by Hypoxia via Cysteine Nitrosylation

Saeid Maghsoudi, Vikram Bhatia, Martha Hinton, Nisha Singh, Modh Wasif Khan, Prashen Chelikani, Shyamala, DakshinamurtiUniversity of Manitoba Faculty of Health Sciences. University of Manitoba Children’s Hospital Research Institute of Manitoba. University of Manitoba College of Dentistry. Canada American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2024; DOI: 10.1165/rcmb.2023-0447OC AbstractPersistent pulmonary hypertension

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General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway

Bin Liu, Dan Yi, Xiaomei Xia, Karina Ramirez, Hanqiu Zhao, Yanhong Cao, Ankit Tripathi, Ryan Dong, Anton Gao, Hongxu Ding, Shenfeng Qiu, Vladimir V. Kalinichenko,You-Yang Zhao, Michael B. Fallon, Zhiyu DaiUniversity of Arizona. Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine.United States CirculationCirculation 2024; 150: 414-417DOI: 10.1161/CIRCULATIONAHA.123.067981 AbstractAbstract Not Available CategoryVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseAnimal Models of Pulmonary Vascular Disease and TherapyPulmonary Vascular Pathology Age Focus: No

General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway Read More »

Lipocalin-2 induced LDHA expression promotes vascular remodelling in pulmonary hypertension

Yao Yao, Xin Bin, Yanxuan Xu, Shaowan Chen, Si Chen, Xiang-Ling Yuan, Yingjie Cao, Tsz Kin NgBeijing Children’s Hospital, Capital Medical University and National Center for Children’s Health. Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Children’s Hospital and Capital Medical University. Chinese Academy of

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Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation

Alban Todesco, Julien Grynblat, Kouamé Kan Firmin Akoumia, Damien Bonnet, Pedro Mendes‐Ferreira, Stéphane Morisset, Denis Chemla, Marilyne Levy, Mathilde Méot, Sophie‐Guiti Malekzadeh‐Milani, Birger Tielemans, Benoit Decante, Carine Vastel‐Amzallag, Paul Habert, Maria‐Rosa Ghigna, Marc Humbert, David Montani, David Boulate, Frédéric PerrosNorth Hospital Aix Marseille University, Assistance Publique-Hôpitaux de Marseille. INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies Le Plessis. Hôpital Necker-Enfants malades AP-HP Université de Paris Cité. Le Kremlin-Bicêtre Université Paris-Saclay. Faculty of Medicine of

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Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

Alexander Seidinger, Richard Roberts, Yan Bai, Marion Müller, Eva Pfeil, Michaela Matthey, Sarah Rieck, Judith Alenfelder, Gabriele M. KUonig, Alexander Pfeifer, Evi Kostenis, Anna Klinke, Bernd K. Fleischmann, Daniela WenzelUniversity Hospital of the Ruhr University of Bochum and Ruhr University of Bochum. University Hospital of Nottingham. Massachusetts General Hospital and Harvard Medical School. University of

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