Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease Archives - Page 10 of 16

Advances in the research of sulfur dioxide and pulmonary hypertension

Xin Liu, He Zhou, Hongsheng Zhang, Hongfang Jin, Yan HeBeijing Anzhen Hospital and Capital Medical University. Tulane University School of Medicine. Peking University First Hospital and Peking University.China and United States Frontiers in PharmacologyFront Pharmacol 2023; 14:DOI: 10.3389/fphar.2023.1282403 AbstractPulmonary hypertension (PH) is a fatal disease caused by progressive pulmonary vascular remodeling (PVR). Currently, the mechanisms underlying […]

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Loss of Prolyl Hydroxylase 1 and 2 in SM22α-Expressing Cells Prevents Hypoxia-Induced Pulmonary Hypertension

Elizabeth A. Barnes, Reiji Ito, Xibing Che, Cristina M. Alvira, David N. CornfieldStanford University.United States and Japan American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; DOI: 10.1152/ajplung.00428.2022 AbstractPulmonary arterial hypertension (PAH) is a disease characterized by increased vasoconstriction and vascular remodeling. Pulmonary artery smooth muscle cells (PASMC) highly

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Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension

Hidehiro Suginobe, Hidekazu Ishida, Yoichiro Ishii, Kazutoshi Ueda, Chika 5 Yoshihara, Atsuko Ueyama, Renjie Wang, Hirofumi Tsuru, Kazuhisa Hashimoto, Masaki Hirose, Ryo Ishii, Jun Narita, Yasuji Kitabatake, Keiichi OzonoOsaka University Graduate School of Medicine. Osaka Children’s and Women’s Hospital. Niigata University School of Medicine.Japan Human Molecular GeneticsHum Mol Genet 2023; DOI: 10.1093/hmg/ddad162 AbstractDown syndrome (DS) is

Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension Read More »

The emerging roles of SUMOylation in pulmonary diseases

Xuyang Zheng, Lingqiao Wang, Zhen Zhang, Huifang TangThe Affiliated Hangzhou First People’s Hospital, Zhejiang Respiratory Drugs Research Laboratory and Zhejiang University School of Medicine. China Molecular MedicineMol Med 2023; 29: DOI: 10.1186/s10020-023-00719-1 AbstractSmall ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair,

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Human pulmonary microvascular endothelial cell DDAH1-mediated nitric oxide production promotes pulmonary smooth muscle cell apoptosis in co-culture

Hanadi Almazroue, Yi Lin, Leif D. Nelin, John C. Barba II, Avante D. Milton, Jennifer K. TrittmannAbigail Wexner Research Institute at Nationwide Children’s Hospital. The Ohio State University College of Medicine.United States American Journal of Physiol Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L360-L367DOI: 10.1152/ajplung.00433.2021 AbstractBronchopulmonary dysplasia (BPD) is the

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Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph KnosallaDeutsches Herzzentrum der Charité. Charité-Universitätsmedizin Berlin. Freie Universität Berlin and Humboldt-Universität zu

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Metabolomic differences in connective tissue disease-associated versus idiopathic pulmonary arterial hypertension in the PVDOMICS cohort

Catherine E. Simpson, Anna R. Hemnes, Megan Griffiths, Gabriele Grunig, W. H. Wison Tang, Joe G. N. Garcia, John Barnard, Suzy A. Comhair, Rachel L. Damico, Stephen C. Mathai, Paul M. Hassoun, the PVDOMICS Study GroupJohns Hopkins University. Vanderbilt University. University of Texas Southwestern Medical Center. New York University Grossman School of Medicine. Cleveland Clinic.

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