Vascular Cell Biology and Mechanisms of Pulmonary Vascular Disease

Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins

Hideyuki Kato, Yaqin Yana Fu, Jiaquan Zhu, Shabana Aafaqi, Otto Rahkonen, Cameron Slorach, Alexandra Traister, Chung Ho Leung, David Chiasson, Luc Mertens, Lee Benson, Richard D. Weisel, Boris Hinz, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneHospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ […]

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Lymphatic Endothelial Cell Defects in Congenital Cardiac Patients With Postoperative Chylothorax

Aqsa Shakoor, June K. Wu, Ajit Muley, Christopher Kitajewski, Joseph D. McCarron, Noa Shapiro-Franklin, Rozelle Corda, Sophia Chrisomalis-Dringe, Paul J. Chai, Carrie J. ShawberColumbia University Irving Medical Center Vagelos College of Physicians & Surgeons and New York Presbyterian Hospital/Morgan Stanley Children’s Hospital.United States Journal of Vascular AnomaliesJ Vasc Anol 2021; 2: DOI: 10.1097/jova.0000000000000016 AbstractObjectives: Chylothorax following cardiac

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Abnormalities in the Von Willebrand-Angiopoietin Axis Contribute to Dysregulated Angiogenesis and Angiodysplasia in Children With a Glenn Circulation

Carlo R. Bartoli, Samson Hennessy-Strahs, Robert D. Dowling, J. William Gaynor, Andrew C. GlatzHospital of the University of Pennsylvania, Children’s Hospital of Philadelphia and University of Pennsylvania. Penn State University College of Medicine.United States Journal of the American College of Cardiology Basic Translational ScienceJACC Basic Transl Sci 2021; 6: 222-235DOI: 10.1016/j.jacbts.2020.12.014 AbstractChildren with a bidirectional superior

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sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate?

Andrew D. Spearman, Ankan Gupta, Amy Y. Pan, Todd M. Gudausky, Susan R. Foerster, G. Ganesh Konduri, Ramani RamchandranMedical College of Wisconsin and Children’s Wisconsin. United States Frontiers in PediatricsFront Pediatr 2021; 9: DOI: 10.3389/fped.2021.679572 AbstractBackground: Pulmonary arteriovenous malformations (PAVMs) are common sequelae of palliated univentricular congenital heart disease, yet their pathogenesis remain poorly defined. In this

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Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A

Hanrong Cheng, Li Chen, Yongli Wei, Tianyong Hu, Dongcai Li, Benqing WuShenzhen People’s Hospital, The Second Clinical Medical College of Jinan University and First Affiliated Hospital of Southern University of Science and Technology. Longgang ENT Hospital.University of Chinese Academy of Science-Shenzhen Hospital.China Journal of Bioenergetics and BiomembranesJ Bioenerg Biomembr 2021; 53: 13-23DOI: 10.1007/s10863-020-09863-3 AbstractBronchopulmonary dysplasia (BPD)

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A Read More »

SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension

Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, Olin D. Liang, Ali Ashek, Olivier Dubois, Lin Zhao, Farah Sabrin, Inês Cebola, Jorge Ferrer, Nicholas W. Morrell, James R. Klinger, Martin R. Wilkins, Lan Zhao, Christopher J. RhodesHammersmith Hospital and Imperial College. Amsterdam University Medical Center. Rhode Island Hospital and Warren Alpert Medical School

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Metakaryotic cells linked to pediatric pulmonary vein stenosis

Edward C. Kirkpatrick, Michael E. Mitchell, William G. Thilly, Pip Hidestrand, Aoy Tomita-Mitchell, Mats Hidestrand, Elena V. GostjevaChildren’s Hospital of Wisconsin and Medical College of Wisconsin. Massachusetts Institute of Technology. Eastern Maine Medical Center.United States Cardiovascular PathologyCardiovasc Pathol 2019; 39: 51-53DOI: 10.1016/j.carpath.2018.12.005 AbstractNo Abstract AvailableMethods:Pulmonary vein tissue from five patients with PVS was collected at the

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Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension

Mohammad Shafiq, Zahid Rasool Lone, Adam Olaitan Abdulkareem, Gurpreet Kaur, Sai Navya, Himalaya Singh, Kumaravelu Jagavelu, Kashif HanifCSIR-Central Drug Research Institute and Academy of Scientific and Innovative Research. Ann & Robert H. Lurie Children’s Hospital. University of Illorin.India and United States Pulmonary Pharmacology and TherapeuticsPulm Pharmacol Ther 2023; 80: DOI: 10.1016/j.pupt.2023.102200 AbstractEndothelial dysfunction is critical in

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Novel Loss of Function KCNA5 Variants in Pulmonary Arterial Hypertension

Alba Vera-Zambrano, Mauro Lago-Docampo, Natalia Gallego, Juan Felipe Franco-Gonzalez, Daniel Morales-Cano, Alejandro Cruz-Utrilla, Marta Villegas-Esguevillas, Edgar Fernandez-Malave, Pilar Escribano-Subias, Jair Antonio-Tenorio-Castano, Francisco Perez-Vizcaino, Diana Valverde, Teresa Gonzalez, Angel CogolludoUniversidad Complutense de Madrid Facultad de Medicina. Universidad Autonoma de Madrid Facultad de Medicina. Instituto de Investigaciones Biomedicas Alberto Sols. Universidad de Vigo. Galicia Sur Health Research

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Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension

Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala DakshinamurtiChildren’s Hospital Research Institute of Manitoba and University of Manitoba.Canada Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1144574 AbstractIntroduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in

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