Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Pre-Flight Hypoxemia Challenge Testing in Bronchopulmonary Dysplasia

Jonathan C. Levin, Catherine A. Sheils, Lystra P. HaygenBoston Children’s Hospital and Brigham and Women’s Hospital.United States PediatricsPediatrics 2023; 152DOI: 10.1542/peds.2022-061001 AbstractBackground and objectives: Former premature infants with bronchopulmonary dysplasia (BPD) are at risk for hypoxemia during air travel, but it is unclear until what age. We aimed to determine pass rates for high altitude simulation testing […]

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Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Xin-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan, Yangzhige He, Guang-Ming Wang,Yu Dong, Ying Yang, Yi-Min Sun, Yong-Hong Ren, Qiu-Yan Zhao, Xiao-Dan Yang, Li-Ying Wang, Cai-Jun Fu, Miao He, Si-Jin Zhang, Ji-Fen Fu, Hong Liu, Zhi-Cheng JingThe First Affiliated Hospital of Dali University. Henan University. The Affiliated Hospital of Guizhou Medical University. Yulong

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Regulatory B cells protect against chronic hypoxia-induced pulmonary hypertension by modulating the Tfh/Tfr immune balance

Cheng Li, Pingping Liu, Huiling Yao, Hao Zhu, Shaoze Zhang, Famg Meng, San Li, Guang Li, Yanping Peng, Jing Gu, Liming Zhu, Yongliang Jiang, Aiguo DaiHunan Provincial People’s Hospital and The First Affiliated Hospital of Hunan Normal University. Hunan Children’s Hospital. Hunan University of Chinese Medicine. Hunan Province Key Laboratory of Vascular Biology and Translational

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Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension

Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala DakshinamurtiChildren’s Hospital Research Institute of Manitoba and University of Manitoba.Canada Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1144574 AbstractIntroduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in

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Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model

R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R.

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Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes

Tatyana Baranova, Ekaterina Podyacheva, Tatyana Zemlyanukhina, Dmitrii Berlov, Maria Danilova, Oleg Glotov, Andrey GlotovSaint Petersburg State University. D.O. Ott’s Institute of Obstetrics. Pediatric Research and Clinical Center for Infectious Diseases.Russia International Journal of Molecular SciencesInt J Mol Sci 2022; 23: DOI: 10.3390/ijms23169433 AbstractThe diving reflex is an oxygen-saving mechanism which is accompanied by apnea, reflex bradycardia

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Identification of the Key Pathways and Genes in Hypoxia Pulmonary Arterial Hypertension Following Intrauterine Growth Retardation

Weifen Zhu, Ziming Zhang, Weiwei Gui, Zheng Shen, Yixin Chen, Xueyao Yin, Li Liang, Lin LiThe Affiliated Sir Run Run Shaw Hospital, Children’s Hospital and The First Affiliated Hospital of Zhejiang University.China Frontiers in Molecular BiosciencesFront Mol Biosci 2022; DOI: 10.3389/fmolb.2022.789736 AbstractHigh-throughput sequencing and weighted gene co-expression network analysis (WGCNA) were used to identify susceptibility modules

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Cardiac involvement in two rare neuromuscular diseases: LAMA2-related muscular dystrophy and SELENON-related myopathy

Karlijn Bouman, Madelief Gubbels, Frederik M. A. van den Heuvel, Jan T. Groothuis, Corrie E. Erasmus, Robin Nijveldt, Floris E. A. Udink ten Cate, Nicol C. VoermansRadboud University Medical Center and Amalia Children’s Hospital. Netherlands Neuromuscular DisordersNeuromuscul Disord 2022; 32: 635-642DOI: 10.1016/j.nmd.2022.06.004 AbstractLAMA2-related muscular dystrophy (LAMA2-MD) and SELENON(SEPN1)-related myopathy (SELENON-RM) are rare neuromuscular diseases caused by

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Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia

Tsering Stobdan, Pritesh P. Jain, Mingmei Xiong, Vineet Bafna, Jason X.-J. Yuan, Gabriel G. HaddadUniversity of California San Diego. Rady Children’s Hospital.United States Human Molecular GeneticsHum Mol Genet 2022; 31: 1130-1140DOI: 10.1093/hmg/ddab291 AbstractThe molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and

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Dichotomous role of integrin-β5 in lung endothelial cells

Neil Blanchard, Patrick A. Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D. Cool, Rebecca L. Heise, Robert Freishtat, Laszlo FarkasUniversity of Virginia. Ohio State University. Children’s National Health System. University of Colorado. Virginia Commonwealth University.United States Pulmonary CirculationPulm Circ 2022; DOI: 10.1002/pul2.12156 AbstractPulmonary arterial hypertension (PAH) is a progressive,

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