Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Circ_0068481 affects the human pulmonary artery smooth muscle cells’ progression by miR-361-3p/KLF5 axis

Hai-Rong Li, Guan-Liang Chen, Xiao-Li Fang, Xing-jiu Cai, Rong-Li Xu, Dong-Dong Li, Zhi-Wei ZhangSouthern Medical University. Hainan General Hospital and Hainan Affiliated Hospital of Hainan Medical University. Guangdong General Hospital.China American Journal of HypertensionAm J Hypertens 2023; DOI: 10.1093/ajh/hpad028 AbstractBackground: Uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) contributes to the pathogenesis of pulmonary arterial hypertension […]

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Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries

Yan Bai, Guang Li, Laiming Yung, Paul B. Yu, Xingbin AiMassachusetts General Hospital and Harvard Medical School. Brigham and Women’s Hospital. Renmin Hospital and Wuhan University. United States and China American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2023; 325: L114-L124DOI: 10.1152/ajplung.00293.2022 AbstractIntrapulmonary arteries located in the proximal lung

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SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Min Li, Lydie Plecita-Hlavata, Evgenia Dobrinskikh, B. Alexandre McKeon, Aneta Gandjeva, Suzette Riddle, Aya Laux, Ram Raj Prasad, Sushil Kumar, Rubin M. Tuder, Hui Zhang, Cheng-Jun Hu, Kurt R. StenmarkUniversity of Colorado Denver – Anschutz Medical Campus. Czech Academy of Sciences. United States and Czech Republic American Journal of Respiratory Cell and Molecular BiologyAm J

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PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells

Yujing Zhao, Juan Wu, Shuai Guan, Ting Xue, Xiaolei Wei, Dawei Cao, Pengzhou Kong, Xinri ZhangThe First Hospital of Shanxi Medical University. The First People’s Hospital of Datong.China International Journal of Chronic Obstructive Pulmonary DiseaseInt J Chron Obstruct Pulmon Dis 2023; 18: 1319-1332DOI: 10.2147/COPD.S406453 AbstractPurpose: Pulmonary artery hypertension (PAH) is a common complication of chronic obstructive pulmonary

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Pre-Flight Hypoxemia Challenge Testing in Bronchopulmonary Dysplasia

Jonathan C. Levin, Catherine A. Sheils, Lystra P. HaygenBoston Children’s Hospital and Brigham and Women’s Hospital.United States PediatricsPediatrics 2023; 152DOI: 10.1542/peds.2022-061001 AbstractBackground and objectives: Former premature infants with bronchopulmonary dysplasia (BPD) are at risk for hypoxemia during air travel, but it is unclear until what age. We aimed to determine pass rates for high altitude simulation testing

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Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Xin-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan, Yangzhige He, Guang-Ming Wang,Yu Dong, Ying Yang, Yi-Min Sun, Yong-Hong Ren, Qiu-Yan Zhao, Xiao-Dan Yang, Li-Ying Wang, Cai-Jun Fu, Miao He, Si-Jin Zhang, Ji-Fen Fu, Hong Liu, Zhi-Cheng JingThe First Affiliated Hospital of Dali University. Henan University. The Affiliated Hospital of Guizhou Medical University. Yulong

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Regulatory B cells protect against chronic hypoxia-induced pulmonary hypertension by modulating the Tfh/Tfr immune balance

Cheng Li, Pingping Liu, Huiling Yao, Hao Zhu, Shaoze Zhang, Famg Meng, San Li, Guang Li, Yanping Peng, Jing Gu, Liming Zhu, Yongliang Jiang, Aiguo DaiHunan Provincial People’s Hospital and The First Affiliated Hospital of Hunan Normal University. Hunan Children’s Hospital. Hunan University of Chinese Medicine. Hunan Province Key Laboratory of Vascular Biology and Translational

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Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension

Martha Hinton, James A. Thliveris, Grant M. Hatch, Shyamala DakshinamurtiChildren’s Hospital Research Institute of Manitoba and University of Manitoba.Canada Frontiers in PhysiologyFront Physiol 2023; 14: DOI: 10.3389/fphys.2023.1144574 AbstractIntroduction: Hypoxic persistent pulmonary hypertension in the newborn (PPHN) is usually treated with oxygen and inhaled nitric oxide (NO), both pulmonary arterial relaxants. But treatment failure with NO occurs in

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Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model

R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R.

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Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes

Tatyana Baranova, Ekaterina Podyacheva, Tatyana Zemlyanukhina, Dmitrii Berlov, Maria Danilova, Oleg Glotov, Andrey GlotovSaint Petersburg State University. D.O. Ott’s Institute of Obstetrics. Pediatric Research and Clinical Center for Infectious Diseases.Russia International Journal of Molecular SciencesInt J Mol Sci 2022; 23: DOI: 10.3390/ijms23169433 AbstractThe diving reflex is an oxygen-saving mechanism which is accompanied by apnea, reflex bradycardia

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