Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

High-Altitude Pulmonary Edema in Children in Mexico City: A Case Series

Alejandro Ferreiro Marin. María Paula Ferreiro Soria, Karla Sánchz Olivera, Aranza Suárez Ortega, Luis Martin Garrido GarcíaCentro Médico ABC. Universidad Anáhuac México.Mexico High Altitude Medicine and BiologyHigh Alt Med Biol 2026; DOI: 10.1177/15578682261500306 AbstractHigh-altitude pulmonary edema (HAPE) is a potentially life-threatening form of noncardiogenic pulmonary edema caused by hypobaric hypoxia. Although well characterized in adults,

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Macrophages Contribute to Pulmonary Hypertension Associated With Sickle Cell Disease

Christina Lisk, Francesca Cendali, Natalie Westover, Delaney Swindle, Daniel Colon Hidalgo, Caitlin Lewis, Melissa J. Lucero, Nishant K. Rana, Gemlyn George, Saini Setua, Monika Dzieciatkowska, Kathryn Hassel, Christy S. Niemeyer, Kurt Stenmark, Eva Nozik, Angelo D’Alessandro, Paul W. Buehler, David C. IrwinUniversity of Colorado Denver – Anschutz Medical Campus. Children’s Hospital Colorado. University of Maryland

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Extracellular Hemoglobin, Hypoxia, and Macrophage-Mediated Pulmonary Vascular Remodeling in Hemolytic Disease

Melissa J. Lucero, Eva Nozik, Kathryn Hassell, David C. Irwin, Paul W. Buehler, Scott K. FergusonUniversity of Colorado Anschutz Medical Campus. University of Maryland. Embry-Riddle Aeronautical University.United States International Journal of Molecular ScienceInt J Mol Sci 2026; 27: DOI: 10.3390/ijms27188170 AbstractPulmonary hypertension (PH) is a well-recognized complication of chronic hemolytic anemias such as sickle cell

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Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension

Yoshihito Morimoto, Yoshiaki Sato, Katsuhiro Kato, Hidenori Yamamoto, Kentaro Suzuki, Kiyotaka Go, Yoshie Fukasawa, Naoki Ohashi, Yoshiyuki Takahashi, Taichi KatoNagoya University Graduate School of Medicine and Nagoya University Hospital. National Cerebral and Cardiovascular Center. Japan Journal of Molecular and Cellular Cardiology PlusJ Mol Cell Cardiol Plus 2026; 18: DOI: 10.1016/j.jmccpl.2026.100867 AbstractRationale: Although plexiform lesion (PL)

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Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

Inhaled Nitric Oxide and Hypoxic Brain Injury in Newborn Piglets

Shadi Malaeb, John Grothusen, Ferit Tuzer, Maria Delivoria-PapadopoulosDrexel University College of Medicine. United States Nitric OxideNitric Oxide 2026; DOI: 10.1016/j.niox.2026.07.003 AbstractBackground: Inhaled nitric oxide (iNO) is widely used as a pulmonary vasodilator to treat infants with pulmonary hypertension (PHN). Hypoxia (Hx) and acidosis increase pulmonary vascular resistance and contribute to PHN. Perinatal asphyxia and resultant hypoxic-ischemic encephalopathy

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Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension

Aurelia E. Reiser, Markus Thiersch, Max Gassmann, Simon R. Schneider, Laura Mayer, Stéphanie Saxer, Michael Furian, Richard Sparla, Esther I. Schwarz, Mona Lichtblau, Martina U. Muckenthaler, Silvia UlrichUniversity of Zürich and University Hospital of Zurich. Eastern Switzerland University of Applied Sciences. University of Heidelberg. Switzerland and Germany Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70352 AbstractIron deficiency

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SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension

Xiao-He Xu, Yi Shen, Min Chen, Yu-Xin Miao, Lin Cheng, Yang-Han-Yue Zhao, Yang Fang, Dai-Ji Jiang, Fang Yu, Yang-Yang He, Zhuo-Yuan Xu, Li-Jun Fu, Li-Wei Wu, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Henan University. Second Affiliated Hospital, Yuying Children’s Hospital, Wenzhou Medical

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Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats

Guoliang Wang, Jie Liu, Peiyi Bai, Hong Jiao, Xiaohui Kong, Zhangke Guo, Gaopeng Li, Aijun LiuBeijing Children’s Hospital, Beijing Pediatric Research Institute, Capital Medical University and National Center for Children’s Health. Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences and Tongji Shanxi Hospital. General Hospital of Taiyuan Iron and

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Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension

John D. Dauz, Bahram Mirani, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergHospital for Sick Children and University of Toronto. Ted Rogers Centre for Heart Research. Canada American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2026; DOI: 10.1152/ajpheart.00459.2026 AbstractMain pulmonary artery (MPA) stiffening increases right ventricular (RV)

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