Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to […]

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

Inhaled Nitric Oxide and Hypoxic Brain Injury in Newborn Piglets

Shadi Malaeb, John Grothusen, Ferit Tuzer, Maria Delivoria-PapadopoulosDrexel University College of Medicine. United States Nitric OxideNitric Oxide 2026; DOI: 10.1016/j.niox.2026.07.003 AbstractBackground: Inhaled nitric oxide (iNO) is widely used as a pulmonary vasodilator to treat infants with pulmonary hypertension (PHN). Hypoxia (Hx) and acidosis increase pulmonary vascular resistance and contribute to PHN. Perinatal asphyxia and resultant hypoxic-ischemic encephalopathy

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Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension

Aurelia E. Reiser, Markus Thiersch, Max Gassmann, Simon R. Schneider, Laura Mayer, Stéphanie Saxer, Michael Furian, Richard Sparla, Esther I. Schwarz, Mona Lichtblau, Martina U. Muckenthaler, Silvia UlrichUniversity of Zürich and University Hospital of Zurich. Eastern Switzerland University of Applied Sciences. University of Heidelberg. Switzerland and Germany Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70352 AbstractIron deficiency

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SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension

Xiao-He Xu, Yi Shen, Min Chen, Yu-Xin Miao, Lin Cheng, Yang-Han-Yue Zhao, Yang Fang, Dai-Ji Jiang, Fang Yu, Yang-Yang He, Zhuo-Yuan Xu, Li-Jun Fu, Li-Wei Wu, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Henan University. Second Affiliated Hospital, Yuying Children’s Hospital, Wenzhou Medical

SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension Read More »

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats

Guoliang Wang, Jie Liu, Peiyi Bai, Hong Jiao, Xiaohui Kong, Zhangke Guo, Gaopeng Li, Aijun LiuBeijing Children’s Hospital, Beijing Pediatric Research Institute, Capital Medical University and National Center for Children’s Health. Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, Shanxi Academy of Medical Sciences and Tongji Shanxi Hospital. General Hospital of Taiyuan Iron and

Inhalable extracellular vesicle delivered IL-10 mRNA attenuates pulmonary hypertension in rats Read More »

Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension

John D. Dauz, Bahram Mirani, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergHospital for Sick Children and University of Toronto. Ted Rogers Centre for Heart Research. Canada American Journal of Physiology Heart and Circulatory PhysiologyAm J Physiol Heart Circ Physiol 2026; DOI: 10.1152/ajpheart.00459.2026 AbstractMain pulmonary artery (MPA) stiffening increases right ventricular (RV)

Non-invasive surrogate of main pulmonary artery stiffness is associated with right ventricular function in experimental pulmonary arterial hypertension Read More »

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia

Amed Soliz, Jorge SolizFlorida International University and Memorial Regional Hospital. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) and Université Laval. Altitude Baby Association. United States and Canada Respiratory Physiology and NeurobiologyRespir Physiol Neurobiol 2026;DOI: 10.1016/j.resp.2026.104609 AbstractHigh altitude exposes the human fetus and newborn to chronic hypobaric hypoxia, markedly reducing oxygen availability during critical

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia Read More »

Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in Down syndrome

Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy DelaneyUniversity of Colorado Anschutz. United States Frontiers in ImmunologyFront Immunol 2026; DOI: 10.3389/fimmu.2026.1832057 AbstractTrisomy 21 (T21) results in Down syndrome (DS), a condition associated

Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in Down syndrome Read More »

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

M. Elizabeth Moss, Timothy Klouda, Yan Li, Yu Liu, Meng Tan, Yunhye Kim, Yuan Hao, Mark R. Nicolls, Joseph C. Wu, Richard Bucala, Hong Chen, Eungjoo Lee, Karin Tran-Lundmark, Benjamin Raby, Ke YuanBoston Children’s Hospital and Harvard Medical School. Stanford University. University of California, San Diego. Yale School of Medicine. University of Arizona. Lund University

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension Read More »

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension

Yong‐Jian Zhu, Jie‐Jian Kou, Ya‐Cong Bo, Meng‐Jie Zhang, Xin Fan, Lu‐Ling Zhao, Yi Yan, Hong Da Zhang, Wen‐Hui Wu, Ping Yuan, Yan Liu, Jun‐Zhuo Shi, Xiao‐Bin Pang, Yang‐Yang HeFirst Affiliated Hospital of Zhengzhou University. Huaihe Hospital and Henan University. Zhengzhou University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital and Peking Union Medical College. Shanghai Pulmonary Hospital and School of Medicine Tongji University. China Journal of the American Heart AssociationJ Am Heart Assoc

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

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