Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

Cyclopamine Attenuates Pulmonary Arterial Hypertension Development: Implications of Hedgehog Signaling Involvement for the Pathophysiology

Makito Sakurai, Susumu Hosakawa, Yohei Yamaguchi, Susumu Kirimura, Kensuke Ihara, Kenichi Ohashi, Tetsushi Furukawa, Tetsuo Sasano, Kenichi Kashimada, Taku IshiiInstitute of Science Tokyo. Japanese Red Cross Musashino Hospital.  National Center for Child Health and Development. Japan Federation of American Societies for Experimental Biology JournalFASEB J 2025; 39: DOI: 10.1096/fj.202403350R AbstractPulmonary arterial hypertension (PAH) is one of […]

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Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia

Caitlin V. Lewis, Thi-Tina N. Nguyen, Timothy Porfilio, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Daniel Colon Hidalgo, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Rebecca E. Oberley-Deegan, Cassidy Delaney, Eva S. NozikUniversity of Colorado, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado. University of Nebraska Medical Center.United States American Journal of

Vascular EC-SOD limits the accumulation, proinflammatory profibrotic reprogramming, and hyaluronan binding of interstitial macrophages in hypoxia Read More »

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension

Bahram Mirani, John D. Dauz, Kana Yazaki, Neda Latifi, J. Paul Santerre, Michelle P. Bendeck, Craig A. Simmons, Mark K. FriedbergUniversity of Toronto, Ted Rogers Centre for Heart Research and Hospital for Sick Children. Beth Israel Deaconess Medical Center and Harvard Medical School. University of South Florida.Canada and United States Arteriosclerosis, Thrombosis and Vascular BiologyArterioscler,

Right Ventricular Stiffening and Function Are Associated With Main Pulmonary Artery Remodeling in a Rat Model of Pulmonary Hypertension Read More »

MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb

Xiang-Qun Hu, Rui Song, Chiranjib Dasgupta, Stephen Twum-Barimah, Taiming Liu, Abu Ahmed, Shawn F. Hanson, Lubo Zhang, Arlin B. BloodLoma Linda University School of Medicine.United States HypertensionHypertension 2025; DOI: 10.1161/HYPERTENSIONAHA.124.23061 AbstractBackground: Pulmonary hypertension of the newborn is a life-threatening disorder characterized by elevated pulmonary vascular resistance due to maladaptation of the pulmonary circulation after birth. The etiology

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Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients

Gabriel F. Diaz, Carlos E. Diaz‐Castrillon, Alicia Marquez Garcia, Rachel K. Hopper, Vinicio de J. PerezUniversidad Nacional De Colombia. University of Pittsburgh. Centro Policlínico Del Olaya and Clínica De La Mujer. Stanford University School of Medicine. Columbia and United States Pulmonary CirculationPulm Circ 2025; 15: DOI: 10.1002/pul2.70017 AbstractPulmonary hypertension (PH) at high altitudes presents unique characteristics

Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow-up of 86 patients Read More »

miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6

Yingjie Wang, Le Sun, Xianxian Jia, Miao Yang, Wei XuShengjing Hospital of China Medical University.China FASEB JournalFASEB J 2025; 39:DOI: 10.1096/fj.202401069RRR AbstractPulmonary hypertension of the newborn (PHN) is a common pulmonary vascular disease in newborns, affecting the prognosis of affected infants and even leading to death. Currently, there is still no specific targeted prevention and treatment

miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6 Read More »

High Altitude May Protect Against the Early Development of Irreversible Pulmonary Hypertension in Patients With Congenital Heart Disease

Inge von Alvensleben, Brian B. Graham, Gustavo A. Balanza, Carlos Brockmann, Ericka C. Pérez, Ximena Y. Vicente, Carla Arteaga, Claudia Scherer, Franz P. Freudenthal, Rubin M. Tuder, Alexandra HeathKardiozentrum. University of Colorado. University of California San Francisco. Massachusetts General Hospital and Harvard Medical School. Hospital Belga.Bolivia and United States Pulmonary CirculationPulm Circ 2025; 15:  DOI: 10.1002/pul2.70049

High Altitude May Protect Against the Early Development of Irreversible Pulmonary Hypertension in Patients With Congenital Heart Disease Read More »

A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes

Thi-Tina N. Nguyen, Caitlin V. Lewis, Daniel Colon Hidalgo, Janelle N. Posey, Mariah Jordan, Timothy E. Porfilio, Maya R. Grayck, Clyde J. Wright, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Frontiers in PhysiologyFront Physiol 2025; 16: DOI: 10.3389/fphys.2025.1513703 AbstractExtremely preterm birth predisposes infants to bronchopulmonary dysplasia and associated pulmonary hypertension (PH).

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Prolonged postnatal adaptation and enhanced prevalence of congenital heart diseases due to altitude may contribute to newborn mortality in Bolivia

Alexandra Heath, Inge von Alvensleben, Jesús Ardiles Spielvogel, Pablo Freudenthal, Johannes Trapp, Ivanna Noya, Miguel Gálvez, Fanny Mendizábal, Mariana Gonzales, Ceylan Apaza, Leibniz Sanga, Erin Mc Cann, Colleen G. JulianKardiozentrum. University of Witten. University of Munich. Hospital ‘Arco Iris’. Hospital Municipal Boliviano Holandés. University of Cincinnati. University of Colorado.Bolivia, Germany and United States Experimental PhysiologyExp

Prolonged postnatal adaptation and enhanced prevalence of congenital heart diseases due to altitude may contribute to newborn mortality in Bolivia Read More »

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α

Amanda Czerwinski, Paul Sidlowski, Emily Mooers, Yong Liu, Ru-Jeng Teng, Kirkwood Pritchard Jr., Xigang Jing, Suresh Kumar, Amy Y. Pan, Pengyuan Liu, Girija G. Konduri, Adeleye AfolayanMedical College of Wisconsin. University of Arizona College of Medicine. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2025; DOI: 10.1165/rcmb.2024-0353OC AbstractHypoxia-inducible factors

Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α Read More »

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