Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia

Amed Soliz, Jorge SolizFlorida International University and Memorial Regional Hospital. Institute Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ) and Université Laval. Altitude Baby Association. United States and Canada Respiratory Physiology and NeurobiologyRespir Physiol Neurobiol 2026;DOI: 10.1016/j.resp.2026.104609 AbstractHigh altitude exposes the human fetus and newborn to chronic hypobaric hypoxia, markedly reducing oxygen availability during critical

The High-Altitude Baby: Neonatal Development and Survival in Hypoxic Environments Neonatal Life in Hypobaric Hypoxia Read More »

Interferon receptor gene dosage differentially regulates hypoxia-induced platelet activation and pulmonary hypertension in Down syndrome

Janelle N. Posey, Mariah Jordan, Amanda Olsen-Dufour, Thi-Tina N. Nguyen, Christine Farrell, Caitlin V. Lewis, Jamie L. Archambault, Christina Sul, Daniel Colon-Hidalgo, Eva S. Nozik, Joaquin M. Espinosa, Kelly D. Sullivan, Cassidy DelaneyUniversity of Colorado Anschutz. United States Frontiers in ImmunologyFront Immunol 2026; DOI: 10.3389/fimmu.2026.1832057 AbstractTrisomy 21 (T21) results in Down syndrome (DS), a condition associated

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Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension

M. Elizabeth Moss, Timothy Klouda, Yan Li, Yu Liu, Meng Tan, Yunhye Kim, Yuan Hao, Mark R. Nicolls, Joseph C. Wu, Richard Bucala, Hong Chen, Eungjoo Lee, Karin Tran-Lundmark, Benjamin Raby, Ke YuanBoston Children’s Hospital and Harvard Medical School. Stanford University. University of California, San Diego. Yale School of Medicine. University of Arizona. Lund University

Hypoxia Induces Adaptive Lymphangiogenesis via Cd74 and Vegfr3 to Modulate Pulmonary Hypertension Read More »

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension

Yong‐Jian Zhu, Jie‐Jian Kou, Ya‐Cong Bo, Meng‐Jie Zhang, Xin Fan, Lu‐Ling Zhao, Yi Yan, Hong Da Zhang, Wen‐Hui Wu, Ping Yuan, Yan Liu, Jun‐Zhuo Shi, Xiao‐Bin Pang, Yang‐Yang HeFirst Affiliated Hospital of Zhengzhou University. Huaihe Hospital and Henan University. Zhengzhou University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Fuwai Hospital and Peking Union Medical College. Shanghai Pulmonary Hospital and School of Medicine Tongji University. China Journal of the American Heart AssociationJ Am Heart Assoc

Amonafide Targeting NTSR1-PI3K/AKT/mTOR Signaling Attenuates Vascular Remodeling in Pulmonary Arterial Hypertension Read More »

CES1 Deficiency is Associated With Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension

Stuti Agarwal, Anuradha Bankar, Lyong Heo, Ankita Mitra, Ananya Chakraborty, Lichao Liu, Flora Huang, Gowri Swaminathan, Natasha Auer, Prakash Chelladurai, Eleana Stephanie Guardado, Juan Matos, Crystal Le, James West, Karthik Suresh, Ramesh Nair, Marlene Rabinovitch, Christophe Morisseau, Bruce D Hammock, Joseph Wu, Zolt Arany, Mark R Nicolls, Vinicio de Jesus PerezStanford Center for Genomics and

CES1 Deficiency is Associated With Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension Read More »

Rethinking timing: Outcomes of late versus early surgical repair of complete atrioventricular septal defect in a resource-limited setting

Andres F. Jimenez, Laura Sanchez, Ivone Pineda, Lina Ramirez, Tomas Chalela, Carlos Obando, Jaime Camacho, Nestor SandovalFundación Cardioinfantil .Columbia Journal of Thoracic and Cardiovascular Surgery OpenJTCVS Open 2025; DOI: 10.1016/j.xjon.2025.101572 AbstractObjective: Complete atrioventricular septal defect (CAVSD) repair is ideally performed within the first 6 months of life; however, in resource-limited settings, access barriers often delay surgery We compared

Rethinking timing: Outcomes of late versus early surgical repair of complete atrioventricular septal defect in a resource-limited setting Read More »

H2S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats

Jie Zheng, Yanan Zhang, Boyang Lv, Yuanyuan Ma, Xuecong Zhong, Junbao Du, Hongfang Jin, Yaqian HuangPeking University First Hospital and Peking University.China BiomedicinesBiomedicines 2026;DOI: 10.3390/biomedicines14040760 AbstractObjectives: Downregulation of the endogenous gasotransmitter hydrogen sulfide (H2S) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). While prophylactic H2S supplementation prevents PAH initiation in different rat models, its ability

H2S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats Read More »

R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice

Daniel Colon Hidalgo, Caitlin V. Lewis, Thi‐Tina N. Nguyen, Janelle N. Posey, Samuel D. Burciaga, Nathan Dee, Christina Sul, Julie Harral, David Irwin, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70307 AbstractPulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling

R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice Read More »

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty-QuintanaMcGovern Medical School University and McWilliams School of Biomedical Informatics of

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response Read More »

Pulmonary artery pressure and cardiac function in children and adolescents after rapid ascent to 3,450 m

Yves Allemann, Thomas Stuber, Stefano F. de Marchi, Emrush Rexhaj, Claudio Sartori, Urs Scherrer, Stefano F. RimoldiInselspital, University Hospital.Switzerland American Journal of Physiology Heart and Circulation PhysiologyAm J Physiol Heart Circ Physiol 2012; 302: H2646-H2653DOI: 10.1152/ajpheart.00053.2012 AbstractHigh-altitude destinations are visited by increasing numbers of children and adolescents. High-altitude hypoxia triggers pulmonary hypertension that in turn may

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