Class 3. Pulmonary Hypertension Associated with Alveolar Hypoxia

CES1 Deficiency is Associated With Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension

Stuti Agarwal, Anuradha Bankar, Lyong Heo, Ankita Mitra, Ananya Chakraborty, Lichao Liu, Flora Huang, Gowri Swaminathan, Natasha Auer, Prakash Chelladurai, Eleana Stephanie Guardado, Juan Matos, Crystal Le, James West, Karthik Suresh, Ramesh Nair, Marlene Rabinovitch, Christophe Morisseau, Bruce D Hammock, Joseph Wu, Zolt Arany, Mark R Nicolls, Vinicio de Jesus PerezStanford Center for Genomics and […]

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Rethinking timing: Outcomes of late versus early surgical repair of complete atrioventricular septal defect in a resource-limited setting

Andres F. Jimenez, Laura Sanchez, Ivone Pineda, Lina Ramirez, Tomas Chalela, Carlos Obando, Jaime Camacho, Nestor SandovalFundación Cardioinfantil .Columbia Journal of Thoracic and Cardiovascular Surgery OpenJTCVS Open 2025; DOI: 10.1016/j.xjon.2025.101572 AbstractObjective: Complete atrioventricular septal defect (CAVSD) repair is ideally performed within the first 6 months of life; however, in resource-limited settings, access barriers often delay surgery We compared

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H2S Donor Therapy Reverses Established Pulmonary Arterial Hypertension and Pulmonary Vascular Structural Remodeling in Rats

Jie Zheng, Yanan Zhang, Boyang Lv, Yuanyuan Ma, Xuecong Zhong, Junbao Du, Hongfang Jin, Yaqian HuangPeking University First Hospital and Peking University.China BiomedicinesBiomedicines 2026;DOI: 10.3390/biomedicines14040760 AbstractObjectives: Downregulation of the endogenous gasotransmitter hydrogen sulfide (H2S) contributes to the pathogenesis of pulmonary arterial hypertension (PAH). While prophylactic H2S supplementation prevents PAH initiation in different rat models, its ability

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R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice

Daniel Colon Hidalgo, Caitlin V. Lewis, Thi‐Tina N. Nguyen, Janelle N. Posey, Samuel D. Burciaga, Nathan Dee, Christina Sul, Julie Harral, David Irwin, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70307 AbstractPulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling

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Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response

Scott D. Collum, Lisha Zhu, Tingting W. Mills, Rene Girard, Jamie Tran, Tinne C. J. Mertens, Cory Wilson, Nancy Wareing, Erik E. Suarez, Howard J. Huang, Rahat Hussain, Bindu Akkanti, Wenjin J. Zheng, Hari K. Yalamanchili, Bela Patel, Eric J. Wagner, Sandeep Agarwal, Harry Karmouty-QuintanaMcGovern Medical School University and McWilliams School of Biomedical Informatics of

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Pulmonary artery pressure and cardiac function in children and adolescents after rapid ascent to 3,450 m

Yves Allemann, Thomas Stuber, Stefano F. de Marchi, Emrush Rexhaj, Claudio Sartori, Urs Scherrer, Stefano F. RimoldiInselspital, University Hospital.Switzerland American Journal of Physiology Heart and Circulation PhysiologyAm J Physiol Heart Circ Physiol 2012; 302: H2646-H2653DOI: 10.1152/ajpheart.00053.2012 AbstractHigh-altitude destinations are visited by increasing numbers of children and adolescents. High-altitude hypoxia triggers pulmonary hypertension that in turn may

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Acute high-altitude illness: a clinically orientated review

Tom Smedley, Michael PW GrocottInstitute of Child Health, University of Southampton, University Hospital Southampton NHS Foundation Trust. Sir Henry Wellcome Laboratories.United Kingdom British Journal of PainBr J Pain 2013; 7: 85-94DOI: 10.1177/2049463713489539 AbstractAcute high-altitude illness is an encompassing term for the range of pathology that the unacclimatised individual can develop at increased altitude. This includes acute

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Elevated Perspectives: Unraveling Cardiovascular Dynamics in High-Altitude Realms

Kanishk Aggarwal, Mayur Srinivas Pathan, Mayank Dhalani, Inder P. Kaur, Fnu Anamika, Vasu Gupta, Dilip Kumar Jayaraman, Rohit JainDayanand Medical College. Avalon University School of Medicine. GMERS Medical College & Hospital. University of Mississippi Medical Center. University College of Medical Sciences. Main Line Health. Penn State Milton S. Hershey Medical Center.India, Curacao and United States

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High-altitude pulmonary edema with absent right pulmonary artery

Billy Rios, David J. Driscoll, Dan G. McNamaraTexas Children’s Hospital and Baylor Cllege of Medicine.United States PediatricsPediatrics 1985; 75: 314-317DOI: https://doi.org/10.1542/peds.75.2.314 AbstractHigh-altitude pulmonary edema potentially is fatal. Adults with unilateral absence of a right pulmonary artery are particularly susceptible to high-altitude pulmonary edema. The occurrence of high-altitude pulmonary edema was documented in a child with

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Physical adaptation of children to life at high altitude

K. De Meer, H. S. A. Heymans, W. G. ZijlstraUniversity Children’s Hospital Het Wilhelmina Kinderziekenhuis. Beatrix Children’s Clinic and University Hospital Groningen.Netherlands European Journal of PediatricsEur J Pediatr 1995; 154: 263–272DOI: Not Availanble AbstractChildren permanently exposed to hypoxia at altitudes of > 3000 m above sea level show a phenotypical form of adaptation. Under these

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