Pediatric Pulmonary Vascular Disease

Right Atrial Dysfunction Is Prevalent in Pediatric Acute Respiratory Distress Syndrome and Reflects Pulmonary Hypertension and Right Ventricular Dysfunction

Nathan D. Markiewitz, Yan Wang, Robert A. Berg, Nadir Yehya, Celeste Dixon, Laura Mercer-Rosa, Adam S. HimebauchChildren’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania. United States Critical Care ExplorationsCrit Care Exp 2025; 7: DOI: 10.1097/CCE.0000000000001230 AbstractImportance: Right atrial (RA) dysfunction is associated with worse outcomes in some populations with pulmonary hypertension […]

Right Atrial Dysfunction Is Prevalent in Pediatric Acute Respiratory Distress Syndrome and Reflects Pulmonary Hypertension and Right Ventricular Dysfunction Read More »

Management of Obstructed Complete Left Partial Anomalous Pulmonary Venous Return in a Preterm Infant

Timothy R. Harris, Joiliana Lecointe, Thomas P. Doyle, Nhue L. Do, Dana R. Janssen, Garrett N. CoyanVanderbilt University Medical Center. University of Arizona. Meharry Medical College.United States Annals of Thoracic Surgery Short ReportsAnn Thorac Surg Short Rep 2025; 3: 106-108DOI: 10.1016/j.atssr.2024.09.006 AbstractA 25-week preterm neonate was born with complete left-sided partial anomalous pulmonary venous drainage with

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Macitentan: Pediatric First Approval

Susan J. KeamSpringer Nature.New Zealand Paediatric DrugsPaediatr Drugs 2025; DOI: 10.1007/s40272-025-00692-8 AbstractMacitentan (Opsumit®), an endothelin receptor antagonist (ERA) developed by Johnson & Johnson, is well established worldwide as monotherapy or combination therapy for the long-term treatment of pulmonary arterial hypertension (PAH). In September 2024, based on phase 3 clinical data in patients aged < 18 years,

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A maternal hypoxia mouse model to study the effect of late gestational hypoxia on offspring lung outcomes

Thi-Tina N. Nguyen, Caitlin V. Lewis, Daniel Colon Hidalgo, Janelle N. Posey, Mariah Jordan, Timothy E. Porfilio, Maya R. Grayck, Clyde J. Wright, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Frontiers in PhysiologyFront Physiol 2025; 16: DOI: 10.3389/fphys.2025.1513703 AbstractExtremely preterm birth predisposes infants to bronchopulmonary dysplasia and associated pulmonary hypertension (PH).

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Concurrent Bronchopulmonary Sequestration in Congenital Diaphragmatic Hernia: Is Frequency Increasing or Are We Better at Diagnosis?

Michelle J. Yang, Christian C. Yost, Martha Monson, Paula J. Woodward, Anne M. Kennedy, Stephen J. Fenton, Katie W. Russell, Janice L. B. Byrne, Bradley A. YoderPrimary Children’s Hospital and University of Utah School of Medicine.United States Journal of Pediatrics: Clinical PracticeJ Pediatr Clin Pract 2025; DOI: 10.1016/j.jpedcp.2025.200141 AbstractObjective: To assess the incidence and clinical outcomes of

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Recanalization and interventional stenting of a closed ductus arteriosus in pulmonary hypertension associated with von Hippel-Lindau disease: a case report

Emine Gülsah Torun, Denizhan Bagrul, Ibrahim EceAnkara Bilkent City Hospital.Turkey Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125001374 AbstractPulmonary arterial hypertension remains a progressive, life-threatening condition despite advances in medical treatments. We report the first case of the interventional creation of a reverse Potts shunt by stenting a closed ductus arteriosus in a four-year-old child with

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A machine learning approach to predict mortality and neonatal persistent pulmonary hypertension in newborns with congenital diaphragmatic hernia. A retrospective observational cohort study

Luana Conte, Ilaria Amodeo, Giorgio De Nunzio, Genny Rafaeli, Irene Borzani, Nicola Persico, Alice Griggio, Giuseppe Como, Mariarosa Colnaghi, Monica Fumagalli, Donato Cascio, Giacomo CavallaroUniversità Degli Studi Di Palermo. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Laboratory of Interdisciplinary Research Applied to Medicine (DReAM). “E. De Giorgi”, University of Salento. Università Degli Studi Di Milano.

A machine learning approach to predict mortality and neonatal persistent pulmonary hypertension in newborns with congenital diaphragmatic hernia. A retrospective observational cohort study Read More »

Prolonged postnatal adaptation and enhanced prevalence of congenital heart diseases due to altitude may contribute to newborn mortality in Bolivia

Alexandra Heath, Inge von Alvensleben, Jesús Ardiles Spielvogel, Pablo Freudenthal, Johannes Trapp, Ivanna Noya, Miguel Gálvez, Fanny Mendizábal, Mariana Gonzales, Ceylan Apaza, Leibniz Sanga, Erin Mc Cann, Colleen G. JulianKardiozentrum. University of Witten. University of Munich. Hospital ‘Arco Iris’. Hospital Municipal Boliviano Holandés. University of Cincinnati. University of Colorado.Bolivia, Germany and United States Experimental PhysiologyExp

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Transcatheter closure of a huge complex pulmonary arteriovenous malformation with four devices: a case report

Utku Pamuk, Harun Terin, Hazim Alper GursuAnkara Bilkent City Hospital and University of Health Sciences.Turkey Cardiology in the YoungCardiol Young 2025; DOI: 10.1017/S1047951125000575 AbstractPulmonary arteriovenous malformations are abnormal vascular connections between pulmonary arteries and veins, often causing right-to-left shunting. In this report, a 4-year-old boy with low oxygen saturation was diagnosed with a large, complex pulmonary

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Sodium nitrite prevents impaired postnatal alveolar development

Kathrine L. Daniel, Chantal Gaudet, Ali Hamraghani, Nadya Ben Fadel, Behzad Yeganeh, Robert P. JankovChildren’s Hospital of Eastern Ontario Research Institute. University of Ottawa.Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00324.2024 AbstractDeficient nitric oxide (NO) signaling plays a critical role in the pathogenesis of bronchopulmonary

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