Pediatric Pulmonary Vascular Disease

Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare […]

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Thoracoscopic Versus Open Repair of Congenital Diaphragmatic Hernia: A Retrospective Case Series From a Tertiary Care Center

Shishir Kumar, Ratan Kumar, Mrunalkant Panchal, Preeti Srivastava, Sanjay K. TantiTata Main Hospital, Manipal Tata Medical College and Manipal Academy of Higher Education.India CureusCureus 2026; 18: DOI: 10.7759/cureus.111125 AbstractBackground: Congenital diaphragmatic hernia (CDH) remains a challenging neonatal surgical condition associated with significant morbidity and mortality. Thoracoscopic repair has emerged as a minimally invasive alternative to conventional open

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Placental abnormalities of malperfusion, inflammation, and meconium are associated with neonatal pulmonary vascular disease

Stephanie M. Tsoi, Cynthia Gasper, Emin Maltepe, Megan A. Chidboy, Nida Ozarslan, Christine A. Blauvelt, Sirirak Buarpung, Shannon Cheung, Martina Steurer, Roberta L. Keller, Jeffrey R. Fineman, Stephanie L. GawUniversity of California San Francisco. United States PlacentaPlacenta 2026; 182: 341-347DOI: 10.1016/j.placenta.2026.06.024 AbstractObjectives: The primary objective was to elucidate whether placental histopathology representative of intrauterine insults during pulmonary

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Growth-adjusted reference values for the main pulmonary artery-to-ascending aorta ratio derived from clinically indicated chest CT in children

Ying Lyu, Mingshu Yang, Huaqin Bu, Chao Gong, Jinhua Ma, Tingting Luo, Li Zhong, Yongle Zhao, Xiao Yang, Ting Wang, Yan Chen, Daiyin TianChildren’s Hospital of Chongqing Medical University and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Children’s Hospital of Fudan University and National Children’s Medical Center. China European RadiologyEur Radiol

Growth-adjusted reference values for the main pulmonary artery-to-ascending aorta ratio derived from clinically indicated chest CT in children Read More »

Outcome of biventricular repair of congenital cardiac malformations with a borderline left ventricle

Emilie Houdebert, Victoria Benito Arnaiz, Antonio Gonzalez-Calle, Mustafa Rady, Giulia Scopetani, Lorenzo Boni, Maria-Helena Perez, Nicole Sekarski, Stefano Bernardo, Andrew Parry, Amir-Reza HosseinpourLausanne University Hospital and University of Lausanne. University Hospital of Madrid. Virgen del Rocio Hospital and University Hospitals of Seville. Bristol Children’s Hospital. Switzerland, Spain and United Kingdom Journal of Cardiothoracic SurgeryJ Cardiothorac Surg

Outcome of biventricular repair of congenital cardiac malformations with a borderline left ventricle Read More »

Successful Pulmonary Thromboendarterectomy for Malignancy-Associated Septic Chronic Thromboembolic Disease in Children

Andrés Felipe Rubio-Duarte, Laura Isabel Manosalva-Arciniegas, Diego Márquez-Bohorquez, Carolina Riveros-Bustos, Albert Franz Guerrero-BecerraHospital Internacional de Colombia HIC, Fundacion Cardiovascular de Colombia FCV and Fundacion Universitaria FCV. Columbia Journal of the American College of Cardiology Case ReportsJACC Case Rep 2026; DOI: 10.1016/j.jaccas.2026.109336 AbstractBackground: Chronic thromboembolic pulmonary hypertension is exceptionally rare in children and is typically associated with major

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A physiology-guided ketofol-based anaesthetic approach for emergency burr hole craniotomy in a child with Eisenmenger syndrome: a case report

Saad Ahmed Naved, Samiah Ijaz, Bushra Maryum Zahid, Muhammad AshrafShifa International Hospitals Limited.Pakistan BioMedical Central AnesthesiologyBMC Anesthesiol 2026; DOI: 10.1186/s12871-026-04098-y AbstractBackground: Eisenmenger syndrome presents substantial perioperative risk because small perturbations in systemic or pulmonary vascular resistance may precipitate cardiovascular collapse. Evidence guiding anaesthetic management during emergency neurosurgery in paediatric patients remains limited.Case presentation: We report an 11-year-old boy

A physiology-guided ketofol-based anaesthetic approach for emergency burr hole craniotomy in a child with Eisenmenger syndrome: a case report Read More »

Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort

Catherine M. Avitabile, Kimberly Butler, Antara Mondal, David B. Frank, Yan Wang, Devon Ash, Laura Mercer‐Rosa, Michael L. O’Byrne, Ryan CallahanUniversity of Pennsylvania, Perelman School of Medicine and Children’s Hospital of Philadelphia. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70346 AbstractPulmonary hypertension (PH) and right ventricular (RV) dysfunction increase mortality in multivessel pediatric pulmonary vein

Right Ventricular Function Improves With Pulmonary Vasodilator Treatment in Pediatric Patients With Pulmonary Hypertension and Multivessel Pulmonary Vein Stenosis in a Single Center Cohort Read More »

Neonatal Outcomes Following Selective Serotonin Reuptake Inhibitor Use During Pregnancy

Layla Aref, Jacob J. Hughey, Sherwin Shirazi, Jennifer M. S. Sucre, Lisa BastaracheVanderbilt University Medical Center, Vanderbilt University School of Medicine and Vanderbilt University.United States Journal of the American Medical Association Network OpenJAMA Netw Open 2026; 9: DOI: 10.1001/jamanetworkopen.2026.22790 AbstractImportance: Evaluating the safety of selective serotonin reuptake inhibitors (SSRIs) during pregnancy is challenging due to ethical barriers

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Pulmonary Venous Decompressing Collaterals: Angiographic Characteristics and Impact on Outcomes in Pediatric Pulmonary Vein Stenosis

Ashish Saini, Hui Huang, Andrew Jergel, Rosemary Gray, Dennis W. Kim, James KuoChildren’s Healthcare of Atlanta and Emory University School of Medicine. United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04350-9 AbstractPediatric pulmonary vein stenosis (PVS) is a rare, progressive condition associated with significant morbidity and mortality. While pulmonary venous decompressing collaterals (PVDC) have been described, their

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