Pediatric Pulmonary Vascular Disease

Intraamniotic Vitamin D Preserves Lung Development and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia due to Intraamniotic sFlt-1

Michael W. Cookson, Tania Gonzalez, Elisa M. Bye, Greg Seedorf, Sarah Ellor, Brad J. Smith, James C. Fleet, Erica W. MandellUniversity of Colorado, Anschutz School of Medicine and Children’s Hospital Colorado. University of Texas.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2025; DOI: 10.1152/ajplung.00409.2024 AbstractPreterm infants born […]

Intraamniotic Vitamin D Preserves Lung Development and Prevents Pulmonary Hypertension in Experimental Bronchopulmonary Dysplasia due to Intraamniotic sFlt-1 Read More »

Follow-up of transcatheter closure of congenital heart disease complicated with pulmonary arterial hypertension in children

Yanyun Huang, Yuting Chen, Danyan Su, Suyuan Qin, Cheng Chen, Dongli Liu, Bingbing Ye, Yuqin Huang, Piaoliu Yuan, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University. China Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1562782 AbstractBackground: Transcatheter closure is now the preferred treatment for congenital heart disease complicated with pulmonary arterial hypertension (CHD-PAH), but its long-term effects

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Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia: a prospective observational study

Lotte Lemloh, Aster de Vadder, Tamene Melaku, Bartolomeo Bo, Neil Patel, Stefan Holdenrieder, Andreas Mueller, Florian KipfmuellerChildren’s Hospital, University of Bonn. Royal Hospital for Children. Technical University of Munich. University Medical Center Mannheim, University of Heidelberg.Germany and United Kingdom Respiratory ResearchRespir Res 2025; 25: DOI: 10.1186/s12931-025-03188-8 AbstractBackground: Elevated levels of Endothelin-1 (ET-1), a vasoactive peptide, have been

Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia: a prospective observational study Read More »

Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation

Benjamin S. Frank, Sierra Niemiec, Ludmila Khailova, Christopher A. Mancuso, Max B. Mitchell, Gareth J. Morgan, Mark Twite, Michael V. DiMaria, Carmen C. Sucharov, Jesse A. DavidsonUniversity of Colorado. University of Michigan.United States Journal of the American College of Cardiology AdvancesJACC Adv 2025; 4: DOI: 10.1016/j.jacadv.2025.101672 AbstractBackground: Endothelin-1 (ET1) is a potent vasoconstrictor and stimulator of pulmonary

Increased Endothelin-1 Is Associated With Morbidity in Single Ventricle Heart Disease in Children Undergoing Fontan Palliation Read More »

Images: Atypical resolution of sleep-related hypoventilation in congenital central hypoventilation syndrome

Michelle Yoo, Amit Shah, Haitham Shahrour, Hong Li, Ajay S. KasiEmory University and Children’s Healthcare of Atlanta.United States Journal of Clinical Sleep MedicineJ Clin Sleep Med 2025;DOI: 10.5664/jcsm.11644 AbstractPaired-like homeobox 2B (PHOX2B) gene variants cause congenital central hypoventilation syndrome (CCHS) characterized by abnormal ventilatory control necessitating lifelong assisted ventilation (AV). We report a 3-year-old girl who

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Trametinib as a targeted treatment in cardiac and lymphatic presentations of Noonan syndrome

Isabel De Brouchoven, Juan Lorand, Léon Bofferding, Arthur Sorlin, An Van Damme, Olivier DanhaiveSaint-Luc University Hospital,. Luxembourg Hospital Center. Laboratoire National de Santé. University of California San Francisco.Belgium, Luxembourg and United States Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1475143 AbstractIntroduction: Rare pathogenic variants in the PTPN11, KRAS, SOS1 and RAF1 genes are the main molecular causes of Noonan syndrome (NS).

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Prevalence and Predictors of Pulmonary Hypertension in Children with Portal Hypertension: A Single Center Study

Nehal El Koofy, Sawsan Hassan Okasha, Hala Mounir Agha, Noha Ali, Ahmed Said Behairy, Hanan Mina Fouad, Rehab Hamdy ZawamCairo University, Helwan University.Egypt Pediatric Gastroenterology Hepatology and NutritionPediatr Gastroenterol Hepatol Nutr 2025; 28: 101-111DOI: 10.5223/pghn.2025.28.2.101 AbstractPurpose: This study aimed to estimate the prevalence and predictors of portopulmonary hypertension (POPH) in children with portal hypertension.Methods: We recruited children of

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Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review

John T. Wren, Neil Patel, Matthew T. Harting, Patrick J. McNamaraUniversity of Iowa Hospitals and Clinics. Royal Hospital for Children. McGovern Medical School at the University of Texas Health Science Center and Children’s Memorial Hermann Hospital. United States and United Kingdom Journal of PerinatologyJ Perinatol 2025; DOI: 10.1038/s41372-025-02265-6 AbstractDespite a near universal approach focused on physiologic

Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review Read More »

Airway Anomalies Predict Risk of Pediatric Pulmonary Hypertension

Elana R. Kriegel, Aditya Srinivasen, Luke Mammen, Harini Venkataganesh, Jess T. Randall, Lara ReichertAlbany Medical College and Albany Medical Center.United States Pediatric PulmonologyPediatr Pulmonol 2025; 60: DOI: 10.1002/ppul.71028 AbstractIntroduction: Pediatric pulmonary hypertension (PH) significantly contributes to morbidity and mortality due to the progressive nature of the disease in some subtypes, which leads to severe right heart failure,

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Clinical characteristics and impact of exchange transfusion in infant pertussis with extreme leukocytosis

Yuanyuan Wu, Chuan GanSecond Affiliated Hospital of Chongqing Medical University, Children’s Hospital of Chongqing Medical University and Chongqing Medical University. Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity.China Italian Journal of PediatricsItal J Pediatr 2025; 51: DOI: 10.1186/s13052-025-01933-9 AbstractBackground: Extreme leukocytosis in pertussis is a rare condition, and without effective interventions to reduce white

Clinical characteristics and impact of exchange transfusion in infant pertussis with extreme leukocytosis Read More »

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