Pediatric Pulmonary Vascular Disease

Clinical characteristics of children treated with high-frequency oscillation ventilation

Lihua Wen, Xiaohuan Guo, Yiyu Yang, Run Dang, Chunmin Zhang, Feiyan ChenGuangzhou Women and Children’s Medical Center and Guangzhou Medical University.China MedicineMedicine 2025; 104: DOI: 10.1097/MD.0000000000046288 AbstractHigh-frequency oscillation ventilation (HFOV) is a commonly used therapeutic modality in the pediatric intensive care unit, and this study aims to investigate the clinical characteristics of children treated with HFOV. […]

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Clinical and microbiological profile of pneumonia among children with congenital heart diseases at alexandria university children’s hospital

Hani Mahmoud Adel, Marwa Ahmed Meheissen, Asmaa Mahmoud Mohamed Gnina, Nirvana Mahmoud Abdel Fattah, Eman Hamza HassanAlexandria University. Egypt BioMedical Central infectious DiseasesBMC Infect Dis 2025; 25: DOI: 10.1186/s12879-025-11856-9 AbstractBackground: Pneumonia is a significant cause of morbidity and mortality among children with congenital heart diseases (CHD). Consequently, the current study aimed to identify the prevalent pathogens causing

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Pulmonary comorbidities and response to surfactant in late preterm infants: a multicenter cohort study

Iwona Sadowska-Krawczenko, Roman Hożejowski, Jan Mazela, Katarzyna Wróblewska-Seniuk, Tomasz Szczapa, Mateusz Jagła, Piotr Kruczek, Katarzyna Bierła, Renata BokiniecNicolaus Copernicus University in Torun. University Hospital No. 2 in Bydgoszcz. Chiesi Poland. Poznan University of Medical Sciences. Jagiellonian University Medical College. Czerwiakowski Hospital at Siemiradzki. District Hospital, Ostrow. Medical University of Warsaw.Poland Pediatric ResearchPediatr Res 2025;DOI: 10.1038/s41390-025-04634-5 AbstractBackground: Surfactant

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Volume Loading May Compromise Left Ventricular Filling in Patients with a Borderline Hypoplastic Left Ventricle

Machi Yamashita, Hirofumi Saiki, Kanchi Saito, Akira Sato, Seiko Kuwata, Satoshi Nakano, Hideaki Senzaki, Junichi KoizumiIwate Medical University. Nihon Institute of Medical Science.Japan International Heart JournalInt Heart J 2025; 66: 1019-1024DOI: 10.1536/ihj.25-216 AbstractGiven the high prevalence of end-organ damage in the long term after the Fontan procedure, patients presenting with borderline hypoplastic left ventricle (LV) are

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Downregulation of KLF2 impairs pulmonary endothelial function and promotes persistent pulmonary hypertension of the newborn

Ningning Chen, Xiaohang Yin, Dong Wang, Dongmei Zhou, Lili Kang, Xiaoying LiChildren’s Hospital Affiliated to Shandong University (Jinan Children’s Hospital), Cheeloo College of Medicine and Shandong University. China Biochemical PharmacologyBiochem Pharmacol 2025; DOI: 10.1016/j.bcp.2025.117572 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is a severe and progressive disorder with limited therapeutic options. Dysfunction of pulmonary artery endothelial

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Very rare combination of Pierre Robin sequence with patent ductus arteriosus, severe persistent pulmonary hypertension, and sepsis in an Afghan neonate: a case report and literature review

Mansoor Aslamzai, Turyalai Hakimi, Abdul Hakim Mukhlis, Esrar Ahmad MansooriKabul University of Medical Sciences “Abu Ali Ibni Sina”.Afghanistan Oxford Medical Case ReportsOxf Med Case Reports 2025; DOI: 10.1093/omcr/omaf235 AbstractPierre Robin sequence (PRS) is a rare congenital abnormality that may complicate serious circumstances in infants. We report a very rare case of PRS in a five-day-old Afghan

Very rare combination of Pierre Robin sequence with patent ductus arteriosus, severe persistent pulmonary hypertension, and sepsis in an Afghan neonate: a case report and literature review Read More »

Treatable Traits in Pediatric Interstitial Lung Diseases: Bridging the Gap to Tailored Therapeutics

Giuseppe Fabio Parisi, Maria Papale, Giulia Pecora, Santiago Presti, Monica Tosto, Salvatore LeonardiSan Marco Hospital and University of Catania.Italy Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14228190 AbstractPediatric interstitial lung diseases (chILD) are a diverse and complex group of rare but impactful disorders characterized by heterogeneous etiologies and variable clinical courses. Traditional diagnosis-based management

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The Incidence of Pulmonary Hypertension and the Association with Bronchopulmonary Dysplasia in Preterm Infants of Extremely Low Gestational Age: Single Centre Study at the Maternity Hospital of University Medical Centre Ljubljana, Slovenia

Tomaž Križnar, Štefan Grosek, Tina PermeUniversity Medical Centre Ljubljana and University of Ljubljana.Slovenia ChildrenChildren 2025; 12: DOI: 10.3390/children12111441 AbstractBackground: Pulmonary hypertension (PH) occurs in ~25% of infants with moderate-to-severe bronchopulmonary dysplasia (BPD) and is associated with substantial morbidity and mortality. The American Heart Association and American Thoracic Society recommend routine echocardiographic screening for PH in preterm

The Incidence of Pulmonary Hypertension and the Association with Bronchopulmonary Dysplasia in Preterm Infants of Extremely Low Gestational Age: Single Centre Study at the Maternity Hospital of University Medical Centre Ljubljana, Slovenia Read More »

Clinical and Immunological Impact of JAK Inhibition in Concurrent Down Syndrome and STAT1 Gain of Function

Pilar Blanco-Lobo, Paula Gilabert-Prieto, Beatriz de Felipe, David Moreno-Fuentes, Paloma Guisado Hernández, Ana Ortiz-Ramírez, Anna Mensa-Vilaró, Juan I. Aróstegui, Natalia Palmou, Valle Velasco Gonzalez, Ángela Deyà Martinez, Jan Ramakers, José Ivorra-Cortés, Cristina Roca, Elisa Cordero, Inmaculada Guillen, Nicolás Valerdiz Menéndez, José Manuel Lucena, Mirella Gaboli, Peter Olbrich, Olaf NethIBiS/Hospital Universitario Virgen del Rocío and CSIC/Universidad

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Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stage

He Zhang, Sixie Zheng, Zheng Wang, Yingying Xiao, Yuqing Hu, Debao Li, Qing Cui, Chenxi Liu, Yiting Xue, Junhua Wu, Sijuan Sun, Lincai YeAffiliated Women and Children’s Hospital of Ningbo University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. China Cell

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