No Age-Related Focus

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins

Liqun Ning, Stefano Zanella, Martin M. Tomov, Medhi Salar Amoli, Linqi Jin, Bouen Hwang, Maher Saadeh, Huang Chen, Sunder Neelakantan, Lakshmi Prasad Dasi, Reza Avazmohammadi, Morteza Mahmooudi, Holly D. Bauser-Heaton, Vahid SerpooshanEmory University School of Medicine, Children’s Healthcare of Atlanta and Georgia Institute of Technology. Cleveland State University. Texas A&M University. Michigan State University. United […]

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins Read More »

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

Haiyang Tang, Akash Gupta, Seth A. Morrisroe, Changlei Bao, Tae-Hwi Schwantes-An, Geetanjali Gupta, Shuxin Liang, Yanan Sun, Aiai Chu, Ang Luo, Venkateswaran Ramamoorthi Elangovan, Shreya Sangam, Yinan Shi, Samisubbu R. Naidu, Jia-Rong Jheng, Sultan Ciftci-Yilmaz, Noel A. Warfel, Louise Hecker, Sumegha Mitra, Anna W. Coleman, Katie A. Lutz, Michael W. Pauciulo, Yen-Chun Lai, Ali Javaheri,

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension Read More »

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension

Sushil Kumar, Claudia Mickael, Rahul Kumar, Ram Raj Prasad, Nzali V. Campbell, Hui Zhang, Min Li, B. Alexandre McKeon, Thaddeus E. Allen, Brian B. Graham, Yen-Rei A. Yu, Kurt R. StenmarkUniversity of Colorado School of Medicine. University of California San Francisco. Zuckerberg San Francisco General Hospital.United States Frontiers in ImmunologyFront Immunol 2024; 15: DOI: 10.3389/fimmu.2024.1372959 AbstractIntroduction: Hypoxia

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension Read More »

Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells

Yi-Ching Liu, Yu-Hsin Tseng, Yu-Hsin Kuan, Lin-Yen Wang, Shang-En Huang, Siao-Ping Tsai, Iwu-Lai Yeh, Jong-Hau HsuKaohsiung Medical University Hospital and Kaohsiung Medical University. E-Da Hospital and I-Shou University. National Sun Yat-sen University. Chia Nan University of Pharmacy and Science. Taiwan Kaohsiung Journal of Medical ScienceKaohsiung J Med Sci 2024; DOI: 10.1002/kjm2.12835 AbstractPulmonary vascular remodeling is a

Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells Read More »

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells

Zen-Kong Dai, Yi-Chen Chen, Su-Ling Hsieh, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan WuKaohsiung Medical University and Kaohsiung Medical University Hospital. Taiwan PharmaceuticalsPharmaceuticals 2024; 17:DOI: 10.3390/ph17040440 AbstractExposure to hypoxia results in the development of pulmonary arterial hypertension (PAH). An increase in the intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs) is a major trigger for pulmonary

The Xanthine Derivative KMUP-1 Inhibits Hypoxia-Induced TRPC1 Expression and Store-Operated Ca2+ Entry in Pulmonary Arterial Smooth Muscle Cells Read More »

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension

Michael G. Katz, Yoav Hadas, Nataly Shtraizent, Shana Ravvin, Jeko M. Madjarov, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Wake Forest School of Medicine. United States Methods in Molecular BiologyMethods Mol Biol 2024; 2803: 173-185DOI: 10.1007/978-1-0716-3846-0_13 AbstractPulmonary hypertension (PH) is a chronic and progressive disorder characterized by elevated mean pulmonary arterial pressure, pulmonary vascular remodeling,

Unilateral Lung Removal in Combination with Monocrotaline or SU5416 in Rodents: A Reliable Model to Mimic the Pathology of the Human Pulmonary Hypertension Read More »

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension

Xuran Chu, Vahid Kheirollahi, Arun Lingampally, Prakash Chelladurai, Chanil Valasarajan, Ana Ivonne Vasquez-Armendariz, Stefan Hadzic, Ali Khadim, Oleg Pak, Stefano Rivetti, Jochen Wilhelm, Marek Bartkuhn, Slaven Crnkovic, Alena Moiseenko, Mohika Heiner, Simone Kraut, Leila Sotoodeh, Janine Koepke, Guilherme Valente, Clemens Ruppert, Thomas Braun, Christos SamakovlisIoannis Alexopoulos, MAria Looso, Cho-Mong Chao, Susanne Herold, Werner Seeger, Grazyna

GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension Read More »

Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension

Nicolas Philip, Xin Yun, Hongyang Pi, Samuel Murray, Zack Hill, Jay Fonticella, Preston Perez, Cissy Zhang, Wimal Pathmasiri, Susan Sumner, Laura Servinsky, Haiyang Jiang, John C. Huetsch, William M. Oldham, Scott Visovatti, Peter J. Leary, Sina A. Gharib, Evan Brittain, Catherine E. Simpson, Anne Le, Larissa A. Shimoda, Karthik SureshJohns Hopkins University School of Medicine.

Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension Read More »

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling

Ling Tang, Xiao Zhou, Aili Guo, Lizhang Han, Silin PanJinan Central Hospital. Central Hosptial. Qilu Hospital. Qingdao Women and Children’s Hospital. Shandong University.China Cardiovascular ToxicologyCardiovasc Toxicol 2024;DOI: 10.1007/s12012-023-09822-5 AbstractHigh expression of the zinc finger X-chromosomal protein (ZFX) correlates with proliferation, aggressiveness, and development in many types of cancers. In the current report, we investigated the efficacy

Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling Read More »

Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling

Hyunbum Kim, Yu Liu, Jiwon Kim, Yunhye Kim, Timothy Klouda, Sudeshna Fisch, Seung Han Baek, Tiffany Liu, Suzanne Dahlberg, Cheng-Jun Hu, Wen Tian, Xinguo Jiang, Kosmas Kosmas, Helen A Christou, Benjamin D. Korman, Sara O. Vargas, Joseph C. Wu, Kurt R. Stenmark, Vinicio de Jesus Perez, Mark R. Nicolls,Benjamin A. Raby, Ke Yuan European Molecular

Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling Read More »

Scroll to Top