No Age-Related Focus

Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations

Henry Rousseau, Tina Wan, Nhi Nguyen, Jaime Wendt Andrae, Michael Tschannen, Angela J. Mathison, Victor Jin, Olivia Groh, Xingyan Zhou, Stryder M. Meadows, Ramani Ramchandran,Igor Shmarakov, Amy Y. Pan, Andrew D. SpearmanMedical College of Wisconsin and Children’s Wisconsin. Rutgers University. Tulane University. United States bioRxivbioRxiv 2025; DOI: 10.64898/2025.12.08.693095 AbstractBackground: Pulmonary arteriovenous malformations (PAVMs) are vascular complications that […]

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Construction of an early diagnostic model for pulmonary hypertension based on aging-related signature genes and identification of potential therapeutic targets

MengzeWang, Jiafei Lu, Xinyu Li, Huating Xie, Junjie Liang, Jun Luo, Xishu Deng, Guoquan Pan, Bowen Ji, Xiaojie DingKunming Children’s Hospital. Southern Medical University. Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. Taizhou Central Hospital (Taizhou University Hospital). Second Hospital of Jiaxing and Second Affiliated Hospital of Jiaxing University. Zhejiang Rongjun Hospital.

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Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension

John H. Newman, Timothy N. Holt, Joy D. Cogan, Bethany Womack, John A. Phillips III, Chun Li, Zachary Kendall, Kurt R. Stenmark, Milton G. Thomas, R. Dale Brown, Suzette R. Riddle, James D. West, Rizwan HamidVanderbilt University School of Medicine. Colorado State University. Case Western Reserve University. University of Colorado.United States Nature CommunicationsNat Commun 2015;

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Preparation of 18β-Glycyrrhetinic Acid Liposome and Its Therapeutic Effect on Pulmonary Arterial Hypertension

Yanmin Pei, Meidong Si, Xuemei Ma, Siyun Liu, Fang Zhao, Ru ZhouNingxia Medical University and General Hospital of Ningxia Medical University.China Drug Design, Development and TherapyDrug Des Dev Ther 2025; 19: 11119-11144DOI: 10.2147/DDDT.S547530 AbstractPurpose: 18β-Glycyrrhetinic acid liposomes (18β-GA-Lips) were developed to enhance lung-specific drug delivery and optimize the therapeutic management of pulmonary arterial hypertension (PAH).Methods: 18β-GA-Lips of varying

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Exploring the Impact of Platelet-Derived Growth Factor D in Pulmonary Hypertension Development

Philip Tannenberg, Karin Tran‐Lundmark, Ya‐Ting Chang, Hanna Gladh, Frank Chenfei Ning, Christian Westöö, Christian Norvik, Azra Alajbegovic, Sebastian Albinsson, Hans Brunnström, Ulf Hedin, Erika FolestadKarolinska Institutet Stockholm. Skane University Hospital and Lund University. Chang Gung Memorial Hospital.Sweden and Taiwan Pulmonary CirculationPulm Circ 2025; 22: DOI: 10.1002/pul2.70216 AbstractPulmonary arterial hypertension (PAH) is a life-threatening condition with no

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Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension

Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils-Bonnet, Martin Wabitsch, Margaret R. MacLeanUniversity of Strathclyde. Queen Mary University of London. Medical University of Vienna. University of Edinburgh. Laval University. Ulm University Medical Center.United Kingdom, Austria, Canada and Germany

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Mitophagy-associated biomarkers and macrophage involvement in pulmonary arterial hypertension: identification and functional implications

Xiaoyu Zhang, Liming Cheng, Jiahui Xie, Xuejuan Ma, Wenting Gui, Jiaxiang Chen, Kai Liu, Runwei MaFuwai Yunnan Hospital, Kunming Children’s Hospital, Chinese Academy of Medical Sciences and Affiliated Cardiovascular Hospital of Kunming Medical University. China Frontiers in PhysiologyFront Physiol 2025; 14: DOI: 10.3389/fphys.2025.1673181 AbstractBackground: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by pulmonary vascular remodeling

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Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat

Bingbing Ye, Danyan Su, Yuqin Huang, Dongli Liu, Yanyun Huang, Suyuan Qin, Cheng Chen, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University.China Clinical and Experimental HypertensionClin Exp Hypertens 2025; 47: DOI: 10.1080/10641963.2025.2583193 AbstractThis study was designed to elucidate the role of circPcmtd1 in regulating pulmonary artery smooth muscle cells (PASMCs) proliferation and migration, through the HSP90AB1/AKT

Interaction of circPcmtd1 with HSP90AB1 mediates phosphorylation of AKT to regulate pulmonary arterial hypertension induced by high pulmonary blood flow in rat Read More »

Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study

Jian-Jian Yu, Jian-Ge Han, Yi Tan, Jian-Xiang Xu, Amanda LeBlanc, Bradley B. Keller, Jiapeng Huang, Lu CaiUniversity of Louisville School of Medicine. Tianjin University Chest Hospital. Cincinnati Children’s Heart Institute and University of Cincinnati. United States and China World Journal of DiabetesWorld J Diabetes 2025; 13: DOI: 10.4239/wjd.v16.i10.109526 AbstractBackground: Diabetes has become a widespread metabolic disease affecting

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Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation

Baishi Huang, Yu Hao, Zhe Wen, Jie Dong, Shengwei Jin, Hui LiSecond Affiliated Hospital, Yuying Children’s Hospital and Wenzhou Medical University. China Lipids in Health and DiseaseLipids Health Dis 2025; 24:DOI: 10.1186/s12944-025-02746-9 AbstractPulmonary arterial hypertension (PAH) is a devastating disease complicated by pathological features such as proliferation of pulmonary artery smooth muscle cells (PASMCs), vasoconstriction, increased

Role of lipid droplets in pulmonary arterial hypertension: focusing on pulmonary artery smooth muscle cell proliferation Read More »

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