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c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle

Manivannan Yegambaram, Xutong Sun, Qing Lu, Alejandro Garcia Flores, Marina Zemskova, Jamie Soto, Adam Rauckhorst, Emin Maltepe, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackHerbert Wertheim College of Medicine and Florida International University. University of California San Francisco. United States Redox BiologyRedox Biol 2025; DOI: 10.1016/j.redox.2025.103765 AbstractEndothelial cell (EC) dysfunction is key in initiating and progressing […]

c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle Read More »

Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid

Yijun Chen, Qianhui Zhang, Xi Chen, Yahe Xu, Jing Guo, Jiajia Meng, Mingjie Zhang, Bo Wang, Zhuoming XuShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine.China International Journal of Biological MacromoleculesInt J Biol Macromol 2025; DOI: 10.1016/j.ijbiomac.2025.146018 AbstractPulmonary arterial hypertension (PAH) is marked by elevated vascular resistance, right ventricular (RV) failure, and poor

Long noncoding RNA FGD5-AS1-encoded micropeptides improve right heart functions of pulmonary arterial hypertension through restricting the synthesis of hyaluronic acid Read More »

Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension

Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele MiragoliUniversity of Parma. Deutsches Herzzentrum Der Charité, Campus Virchow-Klinikum. University of Verona. University of Pavia. IRCCS Humanitas Research Hospital. Italy and

Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension Read More »

Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation

Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Ting Huang, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao, Qiming Liu, Yunbin XiaoAffiliated Nanhua Hospital and University of South China. Affiliated Children’s Hospital of Xiangya School of Medicine and Central South University (Hunan Children’s Hospital). Johns Hopkins School of Medicine. China and Uhited States

Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation Read More »

Proteomic characterization of type I collagen N-terminal crosslinked peptides

Zsuzsanna Darula, Maxwell C. McCabe, Alex Barrett, Lauren R. Schmitt, Mark D. Maslanka, Anthony J Saviola, Joseph Orgel, Alma Burlingame, Claudia A. Staab-Weijnitz, Kurt Stenmark, Valerie Weaver, Robert J. Chalkley, Kirk C. HansenHungarian Centre of Excellence for Molecular Medicine. HUN-REN Biological Research Centre. University of Colorado Denver, Anschutz Medical Campus. Illinois Institute of Technology. University

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Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids

Yifei Miao, Nicole M. Pek, Cheng Tan, Cheng Jiang, Zhiyun Yu, Kentaro Iwasawa, Min Shi, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Debora I. Sinner, Xingchen Liu, Ko Chih Lin, Cheng-Lun Na, Keishi Kishimoto, Min-Chi Yang, Sushila Maharjan, Jason Tchieu, Jeffrey A. Whitsett, Yu Shrike Zhang, Kyle W. McCracken, Robbert J. Rottier, Darrell N. Kotton,

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids Read More »

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O’Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. PalmerOhio State University. University of Maryland School of Medicine. University of California San Diego. University of Colorado, Anschutz Medical Campus. United States Biotechnology and BioengineeringBiotechnol Bioeng 2025; DOI: 10.1002/bit.70012 AbstractPlasma transferrin (Tf)

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice Read More »

TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension

M. L. Garcia-Hernandez, Javier Rangel-Moreno, Qingfu Xu, Ye Jin Jeong, Soumyaroop Bhattacharya, Ravi Misra, Stacey Duemmel, Ke Yuan, Benjamin D. KormanUniversity of Rochester Medical Center. Boston Children’s Hospital.United States Journal of Clinical Investigation InsightJCI Insight 2025; DOI: 10.1172/jci.insight.174456 AbstractThe pathobiology of pulmonary hypertension (PH) is complex and multiple cell types contribute to disease pathogenesis. We sought

TNF drives aberrant BMP signaling to induce endothelial and mesenchymal dysregulation in pulmonary hypertension Read More »

PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension

Rakhshinda Rehman, Paul Dieffenbach, Shamsudheen K. Vellarikkal, Alexis M. Corcoran, Leilani Pomales, Antonio Arciniegas Rubio, Kaithlin V. Zambrano Vera, Fotios Spyropoulos, Kosmas Kosmas, Hillaire Lam, Harilaos Filippakis, Mark A. Perrella, Laura E. Fredenburgh, Helen ChristouBrigham and Women’s Hospital, Harvard Medical School and Harvard University. Broad Institute. University of New England. Regeneron Pharmaceuticals Inc.United States American

PINK1/Parkin Deficiency Enhances Vascular Remodeling and Aggravates Hypoxia-induced Pulmonary Hypertension Read More »

Insights from precision-cut lung slices-investigating mechanisms and therapeutics for pulmonary hypertension

William R. Studley, Emma Lamanna, Claudia A. Nold‑Petry, Cheng Xue Qin, Jane E. BourkeMonash University. Hudson Institute of Medical Research. Baker Heart and Diabetes Institute. Australia. Respiratory ResearchRespir Res 2025; 26: DOI: 10.1186/s12931-025-03290-x AbstractPrecision-cut lung slices (PCLS) are gaining traction as a versatile ex vivo tool to study mechanisms and treatments for lung diseases. This preparation,

Insights from precision-cut lung slices-investigating mechanisms and therapeutics for pulmonary hypertension Read More »

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