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The Importance of Sex as a Biological Variable in Pulmonary Vascular Research

Mikala Mueller, Sue Gu, Krithika Lingappan, R. Blair Dodson, Chelsea M. MaginUniversity of Colorado. Children’s Hospital of Philadelphia and University of Pennsylvania. Research Triangle Institute International.United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00036.2026 AbstractSex differences shape disease susceptibility, progression, and therapeutic response across human

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Inflachromene attenuates monocrotaline-induced pulmonary arterial hypertension by suppressing the HMGB1-TLR4/RAGE-NF-κB signaling pathway

Yueru Wang, Dina Nuerlan, Bilali Paizula, Yimuran Kawulijiang, Jiyao Chen, Hong Zhu, Wentao Xiao, Zhayier Tueraili, Guoming ZhangFirst Affiliated Hospital of Xinjiang Medical University. Second Affiliated Hospital of Xinjiang Medical University. First Affiliated Hospital of Shihezi University.China International ImmunopharmacologyInt Immunopharmacol 2026; DOI: 10.1016/j.intimp.2026.116712 AbstractPulmonary arterial hypertension (PAH) is a debilitating and fatal cardiovascular disorder marked by

Inflachromene attenuates monocrotaline-induced pulmonary arterial hypertension by suppressing the HMGB1-TLR4/RAGE-NF-κB signaling pathway Read More »

Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of TBX4-related Pulmonary Hypertension

Lea C. Steffes, Kaylie A. Chiles, Sehar R. Masud, Aleen Rahman, Madeline Dawson, Csaba Galambos, Maya E. Kumar, Ripla AroraStanford University School of Medicine. Michigan State University. University of Colorado School of Medicine and Children’s Hospital Colorado.United States Journal of Clinical Investigation InsightsJCI Insights 2026; DOI: 10.1172/jci.insight.194251 AbstractHeterozygous TBX4 variants are the second most common genetic

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R213G-Mediated Redistribution of EC-SOD Protects Against Sugen-Hypoxia Pulmonary Hypertension in Mice

Daniel Colon Hidalgo, Caitlin V. Lewis, Thi‐Tina N. Nguyen, Janelle N. Posey, Samuel D. Burciaga, Nathan Dee, Christina Sul, Julie Harral, David Irwin, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70307 AbstractPulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling

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Hsa_circ_0005372 function as both sponging miR-877-3p and interacting with RNA binding proteins DNMT1 to promote proliferation of human pulmonary smooth muscle cells

Danyan Su, Yuqin Huang, Bingbing Ye, Yanyun Huang, Yusheng PangFirst Affiliated Hospital of Guangxi Medical University.China Translational PediatricsTransl Pediatr 2026; 15: DOI: 10.21037/tp-2025-1-886 AbstractBackground: Circular RNAs (circRNAs) may affect pulmonary artery hypertension (PAH) by regulating the proliferation of pulmonary artery smooth muscle cells (PASMCs), but the specific mechanism has not been fully elucidated. This study aimed to

Hsa_circ_0005372 function as both sponging miR-877-3p and interacting with RNA binding proteins DNMT1 to promote proliferation of human pulmonary smooth muscle cells Read More »

Identification of RUNX1 as a Biomarker for Right Ventricular Remodeling in Pulmonary Arterial Hypertension Using WGCNA

Wenjie Chen, Min Peng, Yusi Chen, Jun Luo, Jingyuan Chen, Haihua Qiu, Jiang LiSecond Xiangya Hospital of Central South University. Third Xiangya Hospital Central South University.China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70297 AbstractRight ventricle (RV) dysfunction is central to pulmonary arterial hypertension (PAH) yet its molecular mechanisms remain unclear. This study aimed to identify biomarkers

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Emerging significance of E3 ubiquitin ligases and Deubiquitinases in pulmonary hypertension

Chao-Wei Ding, Jia-Yong Qiu, Hui Shen, Yi Yan, Ze-Xin Liu, Shen-Shen Huang, Yue-Jiao Ma, Zhi-Cheng JingXiamen Humanity Hospital of Fujian Medical University. Second Hospital of Hebei Medical University. Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences and Southern Medical University. First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and

Emerging significance of E3 ubiquitin ligases and Deubiquitinases in pulmonary hypertension Read More »

Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway

Rui-Xiang Ge, Jun-Zhuo Shi, Bin-Hao Guo, Meng-Jie Zhang, Min Zeng, Xiao-Rui An, Jing-Song Ye, Guo Cheng, Xin Fan, Meng-Wei Wang, Yun-Feng Zhou, Xi Li, Xiao-Bin Pang, Xin-Mei Xie, Hong-Da Zhang, Lu-Ling Zhao, Yang-Yang He, Jie-Jian Kou, Jing Ma, Yi YanHuaihe Hospital and Henan University. Fuwai Hospital and National Center for Cardiovascular Diseases. Shanghai Children’s Medical

Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway Read More »

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng-Jun Hu, Claudia Mickael, Yen-Rei Yu, Rubin M. Tuder, Kurt R. StenmarkUniversity of Colorado Anschutz Medical Campus.United States Comprehensive PhysiologyCompre Physiol 2026; 16: DOI: 10.1002/cph4.70133 AbstractThere is strong evidence supporting inflammatory and autoimmune processes in the pathogenesis of pulmonary arterial hypertension (PAH), although the initiating

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The emerging role of integrin signaling in pulmonary vascular disease

Annika S. Bai, Grith Lykke Sørensen, Aparna B. Sundaram, Wenhan Chang, Rubin M. Tuder, Brian B. Graham Michael H. LeeUniversity of California Santa Barbara. University of California San Francisco. Zuckerberg San Francisco General Hospital. University of Southern Denmark. University of Colorado School of Medicine. United States and Denmark American Journal of Physiology Lung Cellular and

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