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T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension

Cheng Li, Pingping Liu, Hao Zhu, Huan Yang, Jun Zha, Huiling Yao, Shaoze Zhang, Jin Huang, Guang Li, Gang Jiang, Yongliang Jiang, Aiguo DaiHunan Provincial People’s Hospital and First Affiliated Hospital of Hunan Normal University. Hunan Children’s Hospital. Changsha Central Hospital and University of South China. Hunan University of Chinese Medicine. China Respiratory ResearchRespir Res […]

T follicular helper cell is essential for M2 macrophage polarization and pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension Read More »

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

Sajeth Dinakaran, Sima Qutaina, Haitian Zhao, Yuefeng Tang, Zhimin Wang, Santiago Ruiz, Aya Nomura-Kitabayashi, Christine N. Metz, Helen M. Arthur, Stryder M. Meadows, Lionel Blanc, Marie E. Faughnan, Philippe MarambaudFeinstein Institutes for Medical Research and Northwell Health. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Institut Pasteur de Montevideo. Newcastle University. Tulane University. Cohen

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia Read More »

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism

Paulina N. Krause, Gabrielle McGeorge, Jennifer L. McPeek, Sidra Khalid, Leif D. Nelin, Yusen Liu, Bernadette ChenNationwide Children’s Hospital and Ohio State University College of Medicine.United States Physiological ReportsPhysiol Rep 2024; 12: DOI: 10.14814/phy2.70089 AbstractA role for metabolically active adipose tissue in pulmonary hypertension (PH) pathogenesis is emerging. Alterations in cellular metabolism in metabolic syndrome are triggers of PH-related vascular dysfunction. Metabolic reprogramming

Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle cell growth and metabolism Read More »

Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery

Victor H. Ruiz, David Encinas-Basurto, Neftali Ortega-Alarcon, Basanth Babu Eedara, Jeffrey R. Fineman, Stephen M. Black, Heidi M. MansourUniversity of Arizona College of Pharmacy, University of Arizona College of Medicine and University of Arizona. University of Sonora. Florida International University. University of California San Francisco School of Medicine. United States and Mexico American Chemical Society

Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery Read More »

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension

Dong Hun Lee, Andrew J. Jang, Minseong Kim, Sarah S. Chang, Raham Lee, Juyoung Kim, Jing Ma, Michael J. Passineau, Raymond L. Benza, Harry Karmouty‐Quintana, Benjamin T. Kopp Roy L. Sutliff, Wilbur A. Lam, C. Michael Hart, Changwon Park, Bum‐Yong KangEmory University School of Medicine. Chonnam National University. Louisiana State University Health Science Center. Atlanta

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension Read More »

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension

Angelez Fernandez-Gonzalez, Amit Mukhia, Janhavi Nadkarni, Gareth R. Willis, Monica Reis, Kristjan Zhumka, Sally Vitali, Xianlan Liu, Alexandra Galls, S. Alex Mitsialis, Stella KourembanasBoston Children’s Hospital and Harvard Medical School.United States Arteriosclerosis Thrombosis and Vascular BiologyArterioscler Thromb Vasc Biol 2024; DOI: 10.1161/ATVBAHA.124.321264 AbstractBackground: Macrophages play a significant role in the onset and progression of vascular disease in

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension Read More »

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease

Michael G. Katz, Dan G. Ohad, Philip Putter, Nataly Shtraizent, Ehud Shahar, Smadar Tal, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Veterinary Teaching Hospital of the Koret School of Veterinary Medicine and Hebrew University of Jerusalem. Spot On Veterinary Hospital. Senex. Frezent Biological Solutions. Tel-Hai College. Migal-Galilee Research Institute. United States and Israel Frontiers in Veterinary MedicineFront Vet Med 2024; 11: DOI: 10.3389/fvets.2024.1415030 AbstractMyxomatous

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease Read More »

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma Read More »

The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status

Xutong Sun, Santiago Moreno, Manivannan Yegambaram, Qing Lu, Marissa D. Pokharel, Jason T. Boehme, Sanjeev A. Datar, Sayrabh Aggarwal, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of California San Francisco. United States Nitric OxideNitric Oxide 2024; DOI: 10.1016/j.niox.2024.09.009 AbstractPreviously, we have shown that endothelial nitric-oxide synthase (eNOS) dimer levels directly correlate with

The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status Read More »

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang ZhaoNorthwestern University Feinberg School of Medicine.United States Journal of Clinical Investigation InsightJCI Insight 2024; DOI: 10.1172/jci.insight.177926 AbstractPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding GCN2, General control

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension Read More »

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