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Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery

Victor H. Ruiz, David Encinas-Basurto, Neftali Ortega-Alarcon, Basanth Babu Eedara, Jeffrey R. Fineman, Stephen M. Black, Heidi M. MansourUniversity of Arizona College of Pharmacy, University of Arizona College of Medicine and University of Arizona. University of Sonora. Florida International University. University of California San Francisco School of Medicine. United States and Mexico American Chemical Society […]

Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery Read More »

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension

Dong Hun Lee, Andrew J. Jang, Minseong Kim, Sarah S. Chang, Raham Lee, Juyoung Kim, Jing Ma, Michael J. Passineau, Raymond L. Benza, Harry Karmouty‐Quintana, Benjamin T. Kopp Roy L. Sutliff, Wilbur A. Lam, C. Michael Hart, Changwon Park, Bum‐Yong KangEmory University School of Medicine. Chonnam National University. Louisiana State University Health Science Center. Atlanta

PPARγ/ETV2 axis regulates endothelial-to-mesenchymal transition in pulmonary hypertension Read More »

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension

Angelez Fernandez-Gonzalez, Amit Mukhia, Janhavi Nadkarni, Gareth R. Willis, Monica Reis, Kristjan Zhumka, Sally Vitali, Xianlan Liu, Alexandra Galls, S. Alex Mitsialis, Stella KourembanasBoston Children’s Hospital and Harvard Medical School.United States Arteriosclerosis Thrombosis and Vascular BiologyArterioscler Thromb Vasc Biol 2024; DOI: 10.1161/ATVBAHA.124.321264 AbstractBackground: Macrophages play a significant role in the onset and progression of vascular disease in

Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension Read More »

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease

Michael G. Katz, Dan G. Ohad, Philip Putter, Nataly Shtraizent, Ehud Shahar, Smadar Tal, Efrat EliyahuIcahn School of Medicine at Mount Sinai. Veterinary Teaching Hospital of the Koret School of Veterinary Medicine and Hebrew University of Jerusalem. Spot On Veterinary Hospital. Senex. Frezent Biological Solutions. Tel-Hai College. Migal-Galilee Research Institute. United States and Israel Frontiers in Veterinary MedicineFront Vet Med 2024; 11: DOI: 10.3389/fvets.2024.1415030 AbstractMyxomatous

Metabolic gene therapy in a canine with pulmonary hypertension secondary to degenerative mitral valve disease Read More »

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma

Anna Hemnes, Niki Fortune, Katie Simon, Irina A. Trenary, Sheila Shay, Eric Austin, Jamey D. Young, Evan Britain, James West, Megha TalatiVanderbilt University Medical Center and Vanderbilt University.United States Frontiers in MedicineFront Med 2024; DOI: 10.3389/fmed.2024.1387195 AbstractBackground: In PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly

A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma Read More »

The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status

Xutong Sun, Santiago Moreno, Manivannan Yegambaram, Qing Lu, Marissa D. Pokharel, Jason T. Boehme, Sanjeev A. Datar, Sayrabh Aggarwal, Ting Wang, Jeffrey R. Fineman, Stephen M. BlackFlorida International University. University of California San Francisco. United States Nitric OxideNitric Oxide 2024; DOI: 10.1016/j.niox.2024.09.009 AbstractPreviously, we have shown that endothelial nitric-oxide synthase (eNOS) dimer levels directly correlate with

The Mitochondrial Redistribution of eNOS is Regulated by AKT1 and Dimer Status Read More »

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang ZhaoNorthwestern University Feinberg School of Medicine.United States Journal of Clinical Investigation InsightJCI Insight 2024; DOI: 10.1172/jci.insight.177926 AbstractPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure. Recessive mutations of EIF2AK4 gene (encoding GCN2, General control

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension Read More »

Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia

Caitlin V. Lewis, Anastacia M. Garcia, Samuel D. Burciaga, Janelle N. Posey, Mariah Jordan, Thi-Tina Nguyen, Kurt R. Stenmark, Claudia Mickael, Christina Sul, Cassidy Delaney, Eva S. NozikUniversity of Colorado Anschutz Medical Campus. United States Physiological GenomicsPhysiol Genomics 2024; DOI: 10.1152/physiolgenomics.00078.2024 AbstractThe extracellular isoform of superoxide dismutase (SOD3) is decreased in patients and animals with pulmonary

Redistribution of SOD3 expression due to R213G polymorphism affects pulmonary interstitial macrophage reprogramming in response to hypoxia Read More »

G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease

Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D’Silva, Rajamma Mathew, Francesca Cendali, Angelo D’Alessandro, S. M. Shafiqul Alam, Victor Garcia, Joseph M. Miano, Sachin A. GupteNew York Medical College. University of Colorado Anschutz Medical Campus. Medical College of Georgia at Augusta University. United States Journal of the American Medical AssociationJ Am Heart Assoc 2024; DOI: 10.1161/JAHA.123.035174 AbstractBackground: G6PD (glucose-6-phosphate-dehydrogenase) is a key enzyme in the glycolytic pathway and has been implicated in the pathogenesis of cancer

G6pdN126D Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease Read More »

Design and comprehensive characterization of dry powder inhalation aerosols of simvastatin DPPC/DPPG lung surfactant-mimic nanoparticles/microparticles for pulmonary nanomedicine

David Encinas-Basurto, Maria F. Acosta, Basanth Babu Eedara, Jeffrey R. Fineman, Stephen M. Black, Heidi M. MansourUniversity of Arizona. Biopolymers-CTAOA. Florida International University. University of California San Francisco School of Medicine. United States and Mexico Royal Society of Chemistry AdvancesRSC Adv 2024; 14: 29413-29427DOI: 10.1039/d4ra04947k AbstractThe Rho Kinase (ROCK) pathway is recognized to be involved in

Design and comprehensive characterization of dry powder inhalation aerosols of simvastatin DPPC/DPPG lung surfactant-mimic nanoparticles/microparticles for pulmonary nanomedicine Read More »

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