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Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B. GrahamUniversity of California San Francisco. Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. Stanford University. Universidade de Pernambuco.United States and Brazil […]

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension Read More »

Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model

Yi Peng, Jingbo Dai, You-Yang ZhaoAnn and Robert H. Lurie Children’s Hospital of Chicago. Northwestern University Feinberg School of Medicine. United States International Journal of Molecular SciencesInt J Mol Sci 2023; 24: DOI: 10.3390/ijms24032391 AbstractPulmonary arterial hypertension (PAH) is a progressive and inevitably fatal disease characterized by the progressive increase of pulmonary vascular resistance and obliterative

Egln1Tie2Cre Mice Exhibit Similar Therapeutic Responses to Sildenafil, Ambrisentan, and Treprostinil as Pulmonary Arterial Hypertension (PAH) Patients, Supporting Egln1Tie2Cre Mice as a Useful PAH Model Read More »

The Anti-Inflammatory Effects and Clinical Potential of Dexmedetomidine in Pulmonary Arterial Hypertension

Yohei Yamaguchi, Susumu Hosokawa, Go Haraguchi, Yusuke Kajikawa, Makito Sakurai, Taku Ishii, Noboru Ando, Tomohiro Morio, Shozaburo Doi, Tetsushi FurukawaTokyo Medical and Dental University. Saitama Children’s Medical Center. National Hospital Organization Disaster Medical Center. Japan Journal of Pharmacology and Experimental TherapeuticsJ Pharmacol Exp Ther 2023; 385: 88-94DOI: 10.1124/jpet.122.001399 AbstractA pathogenic aspect of pulmonary arterial hypertension (PAH) is the aberrant pulmonary arterial smooth muscle cell

The Anti-Inflammatory Effects and Clinical Potential of Dexmedetomidine in Pulmonary Arterial Hypertension Read More »

Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension

Hui Zhang, Angelo D’Alessandro, Min Li, Julie A. Reisz, Suzette Riddle, Akshay Muralidhar, Todd Bull, Lan Zhao, Evgenia Gerasimovskaya, Kurt R. StenmarkUniversity of Colorado School of Medicine.  Imperial College London. United States and United Kingdom Vascular PharmacologyVasc Pharmacol 2023; 149: DOI: 10.1016/j.vph.2023.107157 AbstractRationale: Sildenafil, a well-known vasodilator known to interfere with purinergic signaling through effects on cGMP,

Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension Read More »

Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertension after C75 treatment

Cuilan Hou, Lijian Xie, Tingxia Wang, Junmin Zheng, Yuqi Zhao, Qingzhu Qiu, Yi Yang, Tingting XiaoShanghai Children’s Hospital and Shanghai Jiao Tong University. NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology. Jin Shan Hospital and Fudan University. The Children’s Hospital and Zhejiang University School of Medicine. China BioMed Central Pulmonary MedicineBMC Pulm Med

Comparative transcription profiling of mRNA and lncRNA in pulmonary arterial hypertension after C75 treatment Read More »

Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model

R. Dale Brown, Kendall S. Hunter, Min Li, Maria G. Frid, Julie Harral, Greta M. Krafsur, Timothy N. Holt, Jason Williams, Hui Zhang, Suzette R. Riddle, Michael G. Edwards, Sushil Kumar, Cheng-Jun Hu, Brian B. Graham, Lori A. Walker, Franklyn B. Garry, Peter M. Buttrick, Tim Lahm, Vitaly O. Kheyfets, Kirk C. Hansen, Kurt R.

Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model Read More »

Lactylation: novel epigenetic regulatory and therapeutic opportunities

Haoqin Fan, Fan Yang, Zhenghui Xiao, Haiyan Luo, Huaiyang Chen, Zhi Chen, Qiming Liu, Yunbin XiaoHengyang Medical School and University of South China. Hunan Children’s Hospital. Second Xiangya Hospital, Central South University. China American Journal of Physiology Endocrinology and MetabolismAm J Physiol Endocrinol Metab 2023; 324: E330-E338DOI: 10.1152/ajpendo.00159.2022 AbstractLactate, which is an end product of glycolysis,

Lactylation: novel epigenetic regulatory and therapeutic opportunities Read More »

Hepatic factor may not originate from hepatocytes

Monica Merbach, Ramani Ramchandran, Andrew D. SpearmanMedical College of Wisconsin and Children’s Wisconsin.United States Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2022; DOI: 10.3389/fcvm.2022.999315 AbstractPulmonary arteriovenous malformations (PAVMs) develop universally in patients with univentricular congenital heart disease. They are believed to form due to lack of an unidentified factor from hepatocytes that perfuses the lungs to maintain

Hepatic factor may not originate from hepatocytes Read More »

Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study

Weili Yang, Pu Zhao, Ping Cao, Chunlin Miao, Xiang Ji, Ya Gao, Peng Li, Jiwen ChengThe Second Affiliated Hospital of Xi’an Jiaotong University. Shaanxi Provincial People’s Hospital.China Journal of Cellular BiochemistryJ Cell Biochem 2022; 123: 736-745DOI: 10.1002/jcb.30216 AbstractLittle is known about differentially expressed genes (DEGs) and alternative splicing (AS) landscapes in congenital lung malformations (CLMs). We

Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study Read More »

Notch signalling in healthy and diseased vasculature

Francesca Del Gaudio, Dongli Liu, Urban LendahlKarolinska Institutet. The First Affiliated Hospital of Guangxi Medical University.Sweden and China Open BiologyOpen Biol 2022; 12: DOI: 10.1098/rsob.220004 AbstractNotch signalling is an evolutionarily highly conserved signalling mechanism governing differentiation and regulating homeostasis in many tissues. In this review, we discuss recent advances in our understanding of the roles that

Notch signalling in healthy and diseased vasculature Read More »

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