Review Articles Concerning Pulmonary Vascular Disease

Insights from precision-cut lung slices-investigating mechanisms and therapeutics for pulmonary hypertension

William R. Studley, Emma Lamanna, Claudia A. Nold‑Petry, Cheng Xue Qin, Jane E. BourkeMonash University. Hudson Institute of Medical Research. Baker Heart and Diabetes Institute. Australia. Respiratory ResearchRespir Res 2025; 26: DOI: 10.1186/s12931-025-03290-x AbstractPrecision-cut lung slices (PCLS) are gaining traction as a versatile ex vivo tool to study mechanisms and treatments for lung diseases. This preparation, […]

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Fetal therapy for congenital diaphragmatic hernia: past, present and future

Nimrah Abbasi, Tim Van Mieghem, Greg RyanMount Sinai Hospital and University of Toronto.Canada World Journal of Pediatric SurgeryWorld J Pediatr Surg 2025;DOI: 10.1136/wjps-2024-000835 AbstractCongenital diaphragmatic hernia (CDH) affects 1/2500-5000 infants and is associated with significant neonatal morbidity and mortality related to pulmonary hypoplasia and pulmonary hypertension. Current estimates of perinatal mortality are between 30-40%. With advances

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Oxygen Saturation Targeting in the Neonatal Intensive Care Unit

Faeq Almudares, Bheru Gandhi, Jonathan Davies, Xanthi Couroucli, Natalie Villafranco, Nidhy Paulose Varghese, Milenka Cuevas Guaman, Charleta Guillory, Binoy ShivannaBaylor College of Medicine.United States Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14113975 AbstractOxygen (O2) is vital for cellular development, function, proliferation, and repair, underscoring its critical role in organogenesis. Both hypoxia (reduced tissue O2)

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Down syndrome and congenital heart disease: perioperative planning and management

Dennis R. Delany, Stephanie S. Gaydos, Deborah A. Romeo, Heather T. Henderson, Kristi L. Fogg, Angela S. McKeta, Minoo N. Kavarana, John M. CostelloMedical University of South Carolina. United States Journal of Congenital CardiologyJ Congenit Cardiol 2021; 5: DOI: 10.1186/s40949-021-00061-3 AbstractApproximately 50% of newborns with Down syndrome have congenital heart disease. Non-cardiac comorbidities may also be

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How to Do Echo for Noninvasive Hemodynamic Evaluation of the Patient in the Intensive Care Unit: A Consensus Statement of the Italian Society of Echocardiography and Cardiovascular Imaging

Maurizio Cusmà Piccione, Luigi Colarusso, Eustachio Agricola, Matteo Cameli, Antonio De Luca, Roberta Manganaro, Agata Barchitta, Antonello D’Andrea, Vito Maurizio Parato, Paolo Trambaiolo, Concetta Zito, Pio Caso, Giovanni Di Salvo, This Document was promoted by Members of the 2024-2025 SIECVI Scientific Documents Committee and Reviewed by Ilaria Caso and Giovanni Di SalvoUniversity of Messina. IRCCS

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The molecular mechanisms of IUGR programmed adulthood cardiovascular disease

Ting Wu, Wen Zhang, Yangong Wang, Hong Luo, Yifei LiWest China Second University Hospital and Sichuan University. Fudan University. China Frontiers in Cell and Developmental BiologyFront Cell Dev Biol 2025; 13: DOI: 10.3389/fcell.2025.1589038 AbstractIntrauterine growth restriction (IUGR) is secondary to several maternal and fetal adverse conditions. Recently, there is a convincing association between the onset of

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Common shunt lesions with pulmonary hypertension-who will benefit from surgery?

Shine Kumar, Raman Krishna KumarAmrita Hospital and Amrita Vishwa Vidyapeetham University.India Indian Journal of Thoracic and Cardiovascular SurgeryInd J Thorac Cardiovasc Surg 2025; 41: 718-729DOI: 10.1007/s12055-024-01786-7 AbstractLeft to right shunts comprise a specific group of congenital heart disease, when identified and treated on time result in excellent outcomes. However, a proportion of these defects do not

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Pulmonary hypertension in 2025: next steps?

Kinjal ParikhINOVA Children’s Hospital.United States Current Opinion in CardiologyCurr Opin Cardiol 2025;DOI: 10.1097/HCO.0000000000001228 AbstractPurpose of review: To review recent updates in pediatric pulmonary hypertension with a special focus on recent recommendations from the World Symposium of Pulmonary Hypertension (WSPH).Recent findings: The third pediatric specific WSPH report highlights updated recommendations for pediatric pulmonary hypertension classification, risk stratification, and management

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Group D of pulmonary arterial hypertension and its relationship to congenital heart disease: Is there a non-invasive way to predict the unpredictable?

Antoine Fakhry AbdelMassih, Alyaa AlAli, Emad Nasr, Eman Hanafy, Musaab RamsiCairo University. heikh Khalifa Medical City and Pure Health Group. Aswan Heart Centre. Helwan University. Egypt and United Arab Emirates Global Cardiology Science and PracticeGlob Cardiol Sci Pract 2025; DOI: 10.21542/gcsp.2025.5 AbstractPulmonary arterial hypertension related to congenital heart disease (PAH-CHD), can pose a few challenging therapeutic

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Postrepair Pulmonary Vein Stenosis: Addressing Anatomic and Patient Risk Factors to Improve Outcomes

Alessia Di Nardo, Elizabeth D. Persaud, Rachel D. VanderlaanUniversity of Toronto and Hospital for Sick Children.Canada Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery AnnualSemin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2025; 28: 107-116DOI: 10.1053/j.pcsu.2025.02.008 AbstractSurgical results for correction of total anomalous pulmonary venous connection (TAPVC) have improved in the current era. Postrepair pulmonary

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