Review Articles Concerning Pulmonary Vascular Disease

Persistent Pulmonary Hypertension of the Newborn: A Practical Review for UK Level 2 Local Neonatal Units

Elnazeer MohamedEast Surrey Hospital.United Kingdom CureusCureus 2026; 18: DOI: 10.7759/cureus.116003 AbstractIn persistent pulmonary hypertension of the newborn (PPHN), pulmonary vascular resistance fails to fall after birth, resulting in right-to-left shunting and hypoxemia out of proportion to the underlying lung disease. Inhaled nitric oxide (iNO) is generally provided by tertiary neonatal intensive care units and neonatal

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Addressing micronutrient deficiencies and vitamin metabolism disorders in pediatric pulmonary hypertension: a strategic proposal for low- and middle-income countries

Mattia Pasquinucci, Marco Scaglione, Sofia Mezzalira, Luisa Bonsembiante, Mariaelena Zaffina, Pietro Pogacnik, Sara Bondanza, Ramona Marini, Maria E. Derchi, Davide MeneghessoSan Bassiano Hospital. Hôpital Universitaire Necker-Enfants Malades. University of Padua.  IRCCS Istituto Giannina Gaslini. Università degli Studi Gugliemo Marconi.Italy and France Frontiers in Cardiovascular MedicineFront Cardiovasc Med 2026; 13: DOI: 10.3389/fcvm.2026.1900356 AbstractBackground: Pediatric pulmonary hypertension

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Portopulmonary hypertension: an integrated approach to diagnosis, risk stratification, and management

Jesús Donate, Susana del Prado, Andrés Tenes, María Jesus del Cerro, Agustín Albillos, Luis TéllezHospital Universitario Ramón y Cajal and Universidad de Alcalá. Spain Annals of HepatologyAnn Hepatol 2026; DOI: 10.1016/j.aohep.2026.102466 AbstractPortopulmonary hypertension (PoPH) is a complex and underrecognized form of pulmonary arterial hypertension arising in the setting of portal hypertension, in which outcomes are

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Extracellular Hemoglobin, Hypoxia, and Macrophage-Mediated Pulmonary Vascular Remodeling in Hemolytic Disease

Melissa J. Lucero, Eva Nozik, Kathryn Hassell, David C. Irwin, Paul W. Buehler, Scott K. FergusonUniversity of Colorado Anschutz Medical Campus. University of Maryland. Embry-Riddle Aeronautical University.United States International Journal of Molecular ScienceInt J Mol Sci 2026; 27: DOI: 10.3390/ijms27188170 AbstractPulmonary hypertension (PH) is a well-recognized complication of chronic hemolytic anemias such as sickle cell

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Hemodynamic Phenotypes in Congenital Diaphragmatic Hernia: Unresolved Questions and Future Directions

John T. Wren, Jr., Neil Patel, Patrick J. McNamara, Patrick Sloan University of Iowa, Royal Hospital for Children. Washington University in St. Louis.United States and United Kingdom ChildrenChildren 2026; 13: DOI: 10.3390/children13091137 AbstractCongenital diaphragmatic hernia (CDH) is increasingly recognized as a dynamic cardiopulmonary disease in which pulmonary hypoplasia, pulmonary hypertension, and cardiac dysfunction interact to shape

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Energetic Decoding of VSMC Plasticity: Metabolic Reprogramming and Phenotypic Switching

Tingyu Yan, Qian Nie, Bo Xu, Xin Peng, Jiecan ZhuoFirst Affiliated Hospital, Hengyang Medical School and University of South China. China Cardiovascular Drugs and TherapyCardiovasc Drugs Ther 2026; DOI: 10.1007/s10557-026-07959-3 AbstractPhenotypic switching of vascular smooth muscle cells (VSMCs) constitutes a pivotal event in the initiation and progression of various vascular diseases, including vascular calcification, atherosclerosis,

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Right Ventricular Myocardial Work by Echocardiography: A Scoping Review of Methodology, Validation, and Clinical Applications

Ehsan hahverdi, Carsten Schneider, Mathias LangeKlinikum Osnabrück. Germany EchocardiographyEchocardiography 2026; 43: DOI: 10.1111/echo.70620 AbstractBackground: Echocardiographic assessment of right ventricular (RV) function remains challenging because conventional functional and deformation indices are strongly influenced by loading conditions. Right ventricular myocardial work (RVMW), derived by integrating myocardial deformation with ventricular pressure, has emerged as a potential framework for

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Post-Tuberculosis Lung Disease: Clinical Spectrum, Management Principles, and Lifelong Consequences

Brian W. Allwood, Alistair Broadhurst, Muhammad Saadiq Moolla, Anthony Carrozzi, Marieke M. van der Zalm, Anthony ByrneStellenbosch University. St Vincent’s Hospital and University of New South Wales clinical School. Socios En Salud Sucursal.South Africa, Australia and Peru Cold Spring Harbor Perspectives in MedicineCold Spring Harb Perspect MedDOI: 10.1101/cshperspect.a041887 AbstractPost-tuberculosis lung disease (PTLD) is an increasingly recognized

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Internet-Based home care education for children with pulmonary hypertension: a public health perspective

Yan Li, Juan Huang, Xuan Zhang, Yanhong Liu, Qingqing SongAffiliated Children’s Hospital of Xiangya School of Medicine, Central South University (Hunan Children’s Hospital).China Frontiers in PediatricsFront Pediatr 2026; 18: DOI: 10.3389/fped.2026.1759723 AbstractBackground: Pediatric pulmonary hypertension (PH) requires complex, specialized home care. Digital health interventions offer scalable solutions to address healthcare disparities, improve educational access, and reduce health

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Myocardial Fibrosis in Pediatric Heart Disease: Mechanisms, Imaging Biomarkers, Clinical Consequences, and Emerging Antifibrotic Therapies

Usama Asghar, Samra Choudhry, Mahwish Jabeen, Khadija Mubashir, Ayrass Zia, Mehwish Sadique, Muhammad Jawad Wakil, Laiba MunawarShalamar Medical and Dental College. Faisalabad Medical University. Fatima Jinnah Medical University. Quaid e Azam Medical College. Al Aleem Medical College. Azra Naheed Medical College. Islam Medical and Dental College.Pakistan Cardiology in ReviewCardiol Rev 2026; DOI: 10.1097/CRD.0000000000001450 AbstractMyocardial fibrosis is increasingly recognized as a central determinant of

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