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Navigating the Unique Challenge of Pulmonary Hypertension From Left-to-Right PDA Shunts in Two Cases of Congenital Diaphragmatic Hernia

John T. Wren, Jr., Rhucha Joshi, Patrick J. McNamaraUniversity of Iowa Healthcare. Children’s Hospital of Orange County. United States EchocardiographyEchocardiography 2026; 43: DOI: 10.1111/echo.70396 AbstractPulmonary hypertension (PH) in congenital diaphragmatic hernia (CDH) is nearly universal yet incredibly complex. A patent ductus arteriosus (PDA) is increasingly utilized to both monitor echocardiographically and manage CDH-PH. However, as pulmonary […]

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Multidisciplinary care of pediatric obesity and its impact on sleep: a review

Ravali Inja, Christopher CieloChildren’s Hospital of Philadelphia.United States Frontiers in SleepFront Sleep 2026; 4: DOI: 10.3389/frsle.2025.1634185 AbstractPediatric obesity has emerged as a significant global health issue with multifaceted consequences, including its impact on sleep health. Obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) are among the serious sleep-related comorbidities in obese children, contributing to impaired

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Stratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age)

Jingwen Zhu, Ming Guo, Xiyu He, Yurui Liifth Medical Center of PLA General Hospital. China Lung Lung 2026; 204: DOI: 10.1007/s00408-025-00865-9 AbstractBackground: Bronchopulmonary dysplasia (BPD) remains a significant complication in very preterm infants (< 32 weeks gestational age). Risk factors may differ between mild and moderate-to-severe BPD, but stratified analyses are limited.Objective: To compare risk factors for mild

Stratified Comparison of Risk Factors for Mild Versus Moderate-to-Severe Bronchopulmonary Dysplasia in Very Preterm Infants (< 32 Weeks Gestational Age) Read More »

Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway

Jie Zhang, Youfei Fan, Yanting Gao, Youpeng JinShandong Provincial Hospital and Second Affiliated Hospital Affiliated to Shandong First Medical University. China Human CellHum Cell 2026; 39: DOI: 10.1007/s13577-026-01348-6 AbstractThe growth of human pulmonary arterial smooth muscle cells (hPASMCs) is one of the key contributors to vascular remodeling in pulmonary arterial hypertension (PAH). Although histone deacetylase 3

Histone deacetylase 3 promotes hypoxia-induced human pulmonary arterial smooth muscle cell proliferation by modulating the CSF2-JAK2-STAT5 signaling pathway Read More »

Pulmonary arterial hypertension after congenital heart defect correction: a call for timely diagnosis and careful risk stratification to improve outcomes

Qiangqiang Li, Yuan He, Andrew Constantine, Konstantinos Dimopoulos, Chen Zhang, Qiang Wang, Hong GuBeijing Anzhen Hospital and Capital Medical University. Queen Elizabeth Hospital Birmingham and University Hospitals Birmingham NHS Foundation Trust. Royal Brompton Hospital and Royal Brompton and Harefield NHS Foundation Trust. Imperial College London.China and United Kingdom European Heart Journal OpenEur Heart J Open

Pulmonary arterial hypertension after congenital heart defect correction: a call for timely diagnosis and careful risk stratification to improve outcomes Read More »

Lung Transplantation and Reverse Potts Shunt for Pulmonary Hypertension in the Pediatric Population

Timothy Klouda, Wai Wong, Francis Fynn-Thompson, Jesse Esch, Maureen B. Josephson, Usha S. Krishnan, Levent Midyat, Mary P. MullenBoston Children’s Hospital and Harvard. Children’s Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania Medical School. Columbia University Irving Medical Center and Morgan Stanley Children’s Hospital of New York Presbyterian. Children’s Hospital

Lung Transplantation and Reverse Potts Shunt for Pulmonary Hypertension in the Pediatric Population Read More »

The Use of Treprostinil for Bronchopulmonary Dysplasia Associated Pulmonary Hypertension

Stephanie M. Tsoi, Claire Parker, Elizabeth Colglazier, Shannon Cheung, Mariam Taleb, Hythem Nawaytou, Elena Amin, Jeffrey R. Fineman, Roberta L. KellerUniversity of California San Francisco.United States Pediatric PulmonologyPediatr Pulmonol 2026; DOI: 10.1002/ppul.71448 AbstractBackground: Treprostinil for the treatment of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) has previously been described in small cohort studies, often used later in the course

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Global Resource Disparities Between Pulmonary Hypertension Centers: Results From the International Survey by the PVRI IDDI Access to Care Workstream

Sasha Z. Prisco, Alexander Kantorovich, Yan Liu, Sandeep Sahay, Roberto Bernardo, Vijay Balasubramanian, J. Usha Raj, Gil Golden, Franz Rischard, the PVRI Innovative Drug Development Initiative Access to Care WorkstreamUniversity of Minnesota Medical School. United Therapeutics Corporation. Houston Methodist Hospital. Stanford University. Indiana University School of Medicine. Valley Advanced Lung Diseases Institute. University of Illinois

Global Resource Disparities Between Pulmonary Hypertension Centers: Results From the International Survey by the PVRI IDDI Access to Care Workstream Read More »

Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study

Yao Zhu, Jiongzhi He, Miner Cai, Lijun Wen, Minxu LiDongguan Maternal and Child Health Care Hospital. First Affiliated Hospital of Jinan University.China Translational PediatricsTransl Pediatr 2025; 14: 3305-3317DOI: 10.21037/tp-2025-535 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening emergency in neonatal intensive care. Traditional treatments such as cylinder-based nitric oxide (NO) delivery systems rely on

Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study Read More »

Fibrotic liver injury in biliary atresia: long-term implications

Maria Hukkinen, Mikko P PakarinenNew Children’s Hospital, University of Helsinki and Helsinki University Hospital.Finland World Journal of Pediatric SurgeryWorld J Pediatr Surg 2025; 8: DOI: 10.1136/wjps-2025-001098 AbstractNormalization of serum bilirubin after Kasai portoenterostomy (KPE) is a prerequisite for long-term native liver (NL) survival. Following a successful KPE, fibrotic liver injury progresses variably, although a significant proportion

Fibrotic liver injury in biliary atresia: long-term implications Read More »

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