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Parenteral treprostinil in paediatric pulmonary arterial hypertension: a systematic review and meta-analysis

Julie Wacker, Raphael Joye, Maurice BeghettiGeneva University Hospitals and Faculty of Medicine and University of Geneva.Switzerland European Respiratory ReviewEur Respir Rev 2026; DOI: 10.1183/16000617.0033-2025 AbstractBackground: Paediatric pulmonary arterial hypertension (PAH) shares commonalities with adult disease but is essentially different regarding complexity and is usually more challenging to treat. Current treatment recommendations are based on expert opinion, small-scale […]

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Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway

Dan Chen, Mei-hui Zhou, Wei-ying Zhu, Zhi-xuan Xing, Sheng-peng Li, Ya-xian Wu, Xiao-lin Sun, Ping Sun, Qing-feng PangWuxi School of Medicine, Jiangnan University Medical Center and Jiangnan University. Maternity and Child Health Care Affiliated Hospital, Jiaxing University. Linyi Maternal and Child Health Hospital. China European Journal of PharmacologyEur J Pharmacol 2026; DOI: 10.1016/j.ejphar.2026.178726 AbstractOxidative stress play

Mitochondria-derived peptide MOTS-c alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice by activating Nrf2 pathway Read More »

Respiratory Syncytial Virus Infection Triggering a Pulmonary Hypertensive Crisis in a Boy With Prader-Willi Syndrome-Associated Sleep-Disordered Breathing

Mari Tsukahara, Hideaki Yagasaki, Koichi Makino, Tomoaki Sano, Takeshi InukaUniversity of Yamanashi.Japan CureusCureus 2026; 18: DOI: 10.7759/cureus.103890 AbstractPrader-Willi syndrome (PWS) is a multisystem genetic disorder frequently complicated by sleep-disordered breathing, including obstructive sleep apnea. Respiratory infections may precipitate acute decompensation in vulnerable patients with PWS. A four-year-old boy with genetically confirmed PWS receiving growth hormone therapy

Respiratory Syncytial Virus Infection Triggering a Pulmonary Hypertensive Crisis in a Boy With Prader-Willi Syndrome-Associated Sleep-Disordered Breathing Read More »

Updates in the Treatment of Pediatric Pulmonary Arterial Hypertension

Danya Z. Jafri, James M. Beck, Samantha A. Kaplan, Allegra Keeler, Bryan Sanchez, Daniela Brady, William H. Frishman, Wilbert S. Aronow, Avi Levine, Erika Rosenzweig, Gregg M. LanierNew York Medical College School of Medicine. Westchester Medical Center.United States Cardiology in ReviewCardiol Rev 2026; DOI: 10.1097/CRD.0000000000001239 AbstractPediatric pulmonary arterial hypertension (PAH) is a relentless and potentially fatal

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Pulmonary Hypertension in Pediatric Patients with Noonan Syndrome Undergoing Cardiac Catheterization

Shane L. Collins, Paul J. Critser, Kimberlee Gauvreau, Diego Porras, Amy E. Roberts, Mary P. MullenBoston Children’s Hospital and Harvard Medical School. Cincinnati Children’s Hospital and University of Cincinnati College of Medicine. United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04235-x AbstractNoonan syndrome (NS) is an autosomal dominant genetic disorder associated with a high incidence of cardiovascular

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Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature

Sixie Zheng, Hao Li, Siqi She, Yiting Xue, Debao Li, Jiapei Wang, Jing Wang, Yuqing Hu, Lincai YeShanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Children’s Hospital of Fudan University and National Children’s Medical Center. Affiliated Women and Children’s Hospital of Ningbo University. China Frontiers in ImmunologyFront Immunol 2026; 17: DOI: 10.3389/fimmu.2026.1780303

Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature Read More »

Lung ultrasound score ≥ 6 predicts surfactant administration decisions in meconium aspiration syndrome: a multicenter prospective study

Qi Chen, Zekai Yu, Lei Cao, Wei Xiong, Mei Zheng, Fei Wang, Shasha Wu, Rijin Yu, Minli Zhou, Cheng Guo, Lin Dong, Shuang LiuShangrao Children’s Hospital and Shangrao Maternal and Child Health Hospital. Hangzhou Dianzi University. Jingdezhen First People’s Hospital. Hubei University of Medicine. Xiangyang First People’s Hospital. Qinghai Red Cross Hospital. Yangzhou Maternal and

Lung ultrasound score ≥ 6 predicts surfactant administration decisions in meconium aspiration syndrome: a multicenter prospective study Read More »

The emerging role of integrin signaling in pulmonary vascular disease

Annika S. Bai, Grith Lykke Sørensen, Aparna B. Sundaram, Wenhan Chang, Rubin M. Tuder, Brian B. Graham Michael H. LeeUniversity of California Santa Barbara. University of California San Francisco. Zuckerberg San Francisco General Hospital. University of Southern Denmark. University of Colorado School of Medicine. United States and Denmark American Journal of Physiology Lung Cellular and

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Pulmonary Hypertension Associated With Vitamin C Deficiency Is Rapidly Reversible

Tomás Woodgate, Jay Patel, Thomas Day, Brodie Knight, Adriani Spanaki, Alistair Calder, Shahin Moledina, Sadia QuyamGreat Ormond Street Hospital. Royal Hospital for Children. Evelina London Children’s Hospital,United Kingdom PediatricsPediatrics 2026; DOI: 10.1542/peds.2025-073645 AbstractWe report 4 children (aged 3-9 years) with severe pulmonary hypertension (PH) associated with vitamin C deficiency. All presented with either musculoskeletal symptoms or

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Animal models of chronic thromboembolic pulmonary hypertension

Yong-Jian Zhu, Lin-Chao Zhou, Xiao-Xue Zhang, Xiao-Yang Ren,Yi Yan, Shao-Fei LiuFirst Affiliated Hospital of Zhengzhou University. Henan Provincial People’s Hospital. Shanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Changhai Hospital and Naval Medical University.China Animal Models and Experimental MedicineAnimal Model Exp Med 2026; DOI: 10.1002/ame2.70167 AbstractChronic thromboembolic pulmonary

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