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Pulmonary Hypoplasia

Aneesha Geraghty, Patrick Smith, Kristen Arnold, Paul S. KingmaUniversity of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center.United States NeoReviewsNeoreviews 2026; 27: e511-e522DOI: 10.1542/neo.27-7-039 AbstractPulmonary hypoplasia is a rare but clinically significant congenital disorder characterized by impaired fetal lung development, leading to impaired growth and maturation of lung parenchyma and pulmonary vasculature. Stemming from […]

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Pilot study to validate endothelium collection from pulmonary artery balloon catheter in children

Maxwell Mathias, Charles Sperrazza, Anas Salkini, Andrew Cave, Courtney T. Griffin, Venkatachalem Sathish, Subhrajit LahiriUniversity of Oklahoma Health College of Medicine. Oklahoma Medical Research Foundation. United States Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05326-4 AbstractPediatric pulmonary hypertension (PH) has high morbidity and mortality, with an estimated 5-year survival of 75% regardless of underlying cause. Pediatric PH most

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Post-translational modification crosstalk in pulmonary arterial hypertension: mechanisms and therapeutic implications

Jialin Liang, Yuxin Xie, Danyan Su, Yusheng Pangirst Affiliated Hospital of Guangxi Medical University. Guangxi University of Chinese Medicine. China Molecular Biology ReportsMol Biol Rep 2026; 53: DOI: 10.1007/s11033-026-12478-3 AbstractPulmonary arterial hypertension (PAH) is a complex vascular disease characterized by endothelial dysfunction, pulmonary arterial smooth muscle cell (PASMC) hyperproliferation, metabolic reprogramming, and immune-inflammatory remodeling. These pathological

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Identification of Clinical Sub-Phenotypes of Sickle Cell Disease Using Latent Class Analysis

Shaina M. Willen, Ann M. Brunson, Oyebimpe O. Adesina, Ted WunUniversity of California Davis. United States American Journal of HematologyAm J Hematol 2026; DOI: 10.1002/ajh.70459 AbstractSickle cell disease (SCD), a monogenic disorder, exhibits variable severity due to genetic and environmental modifiers. Prior studies have proposed hemolytic and vaso-occlusive sub-phenotypes based on limited data. We used latent

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A congenital portosystemic shunt in the neonatal period: case report and literature review

Li Cheng, Shuwen Feng, Yin Shen, Xia Wang, Bingyan He, Dongchi Zhao, Pu YangWomen and Children’s Hospital and Zhongnan Hospital of Wuhan University. China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1836875 AbstractA congenital portosystemic shunt (CPSS), a rare developmental malformation of the portal venous system, often presents with atypical clinical manifestations in the neonatal period

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Elevated hypoxia-inducible factor-1α in pediatric patients with patent ductus arteriosus: a pilot study

Oksana Trębacz, Patrycja Florek, Jacek Podlewski, Teresa Iwaniec, Wojciech Tarała, Piotr Weryński, Łukasz Niemiec, Bernadeta SzewczykSt. Jadwiga the Queen Clinical Regional Hospital. Polish Academy of Science. Dover Fueling Solutions. Jagiellonian University Medical College. Poland Pharmacological ReportsPharmacol Rep 2026; DOI: 10.1007/s43440-026-00883-1 AbstractBackground: Children with complex cyanotic congenital heart disease (CHD) and with pulmonary hypertension (PH) commonly experience hypoxia.

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Sports and Supervised Exercise Programmes for Children and Young Adults with Pulmonary Hypertension. 2026 Consensus Statement from the European Pediatric Pulmonary Vascular Disease Network (EPPVDN) and the Association for European Paediatric and Congenital Cardiology (AEPC)

Dan-Mihai Dorobantu, Alexander van de Bruaene, Werner Budts, Barbara Cifra, Mark K. Friedberg, Peter Fritsch, Michael Khoury, Jan Müller, Alexander Opotowsky, Shubhayan Sanatani, Craig Williams, Georg Hansmann, Guido E. PielesUniversity Hospitals Bristol and Weston NHS Trust and University of Exeter. University Hospitals Leuven and University of Leuven. Hospital for Sick Children and University of Toronto.

Sports and Supervised Exercise Programmes for Children and Young Adults with Pulmonary Hypertension. 2026 Consensus Statement from the European Pediatric Pulmonary Vascular Disease Network (EPPVDN) and the Association for European Paediatric and Congenital Cardiology (AEPC) Read More »

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

Inhaled Nitric Oxide and Hypoxic Brain Injury in Newborn Piglets

Shadi Malaeb, John Grothusen, Ferit Tuzer, Maria Delivoria-PapadopoulosDrexel University College of Medicine. United States Nitric OxideNitric Oxide 2026; DOI: 10.1016/j.niox.2026.07.003 AbstractBackground: Inhaled nitric oxide (iNO) is widely used as a pulmonary vasodilator to treat infants with pulmonary hypertension (PHN). Hypoxia (Hx) and acidosis increase pulmonary vascular resistance and contribute to PHN. Perinatal asphyxia and resultant hypoxic-ischemic encephalopathy

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A Case of High Pressure and High Stakes: Pulmonary Arterial Hypertension Emergence in an Infant With Hereditary Hemorrhagic Telangiectasia

Amal Ahmed, Anna M. Brown, Samantha J. Eagle, Evan L. Brittain, Anna R. Hemnes, Rachel T. Sullivan, Eric D. AustinMeharry Medical College School of Medicine. Vanderbilt University Medical Center and Monroe Carell Jr. Children’s Hospital. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70375 AbstractHereditary hemorrhagic telangiectasia (HHT) is an autosomal‑dominant vascular disease characterized by telangiectasias

A Case of High Pressure and High Stakes: Pulmonary Arterial Hypertension Emergence in an Infant With Hereditary Hemorrhagic Telangiectasia Read More »

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