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A congenital portosystemic shunt in the neonatal period: case report and literature review

Li Cheng, Shuwen Feng, Yin Shen, Xia Wang, Bingyan He, Dongchi Zhao, Pu YangWomen and Children’s Hospital and Zhongnan Hospital of Wuhan University. China Frontiers in PediatricsFront Pediatr 2026; 14: DOI: 10.3389/fped.2026.1836875 AbstractA congenital portosystemic shunt (CPSS), a rare developmental malformation of the portal venous system, often presents with atypical clinical manifestations in the neonatal period

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Elevated hypoxia-inducible factor-1α in pediatric patients with patent ductus arteriosus: a pilot study

Oksana Trębacz, Patrycja Florek, Jacek Podlewski, Teresa Iwaniec, Wojciech Tarała, Piotr Weryński, Łukasz Niemiec, Bernadeta SzewczykSt. Jadwiga the Queen Clinical Regional Hospital. Polish Academy of Science. Dover Fueling Solutions. Jagiellonian University Medical College. Poland Pharmacological ReportsPharmacol Rep 2026; DOI: 10.1007/s43440-026-00883-1 AbstractBackground: Children with complex cyanotic congenital heart disease (CHD) and with pulmonary hypertension (PH) commonly experience hypoxia.

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Sports and Supervised Exercise Programmes for Children and Young Adults with Pulmonary Hypertension. 2026 Consensus Statement from the European Pediatric Pulmonary Vascular Disease Network (EPPVDN) and the Association for European Paediatric and Congenital Cardiology (AEPC)

Dan-Mihai Dorobantu, Alexander van de Bruaene, Werner Budts, Barbara Cifra, Mark K. Friedberg, Peter Fritsch, Michael Khoury, Jan Müller, Alexander Opotowsky, Shubhayan Sanatani, Craig Williams, Georg Hansmann, Guido E. PielesUniversity Hospitals Bristol and Weston NHS Trust and University of Exeter. University Hospitals Leuven and University of Leuven. Hospital for Sick Children and University of Toronto.

Sports and Supervised Exercise Programmes for Children and Young Adults with Pulmonary Hypertension. 2026 Consensus Statement from the European Pediatric Pulmonary Vascular Disease Network (EPPVDN) and the Association for European Paediatric and Congenital Cardiology (AEPC) Read More »

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

Inhaled Nitric Oxide and Hypoxic Brain Injury in Newborn Piglets

Shadi Malaeb, John Grothusen, Ferit Tuzer, Maria Delivoria-PapadopoulosDrexel University College of Medicine. United States Nitric OxideNitric Oxide 2026; DOI: 10.1016/j.niox.2026.07.003 AbstractBackground: Inhaled nitric oxide (iNO) is widely used as a pulmonary vasodilator to treat infants with pulmonary hypertension (PHN). Hypoxia (Hx) and acidosis increase pulmonary vascular resistance and contribute to PHN. Perinatal asphyxia and resultant hypoxic-ischemic encephalopathy

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A Case of High Pressure and High Stakes: Pulmonary Arterial Hypertension Emergence in an Infant With Hereditary Hemorrhagic Telangiectasia

Amal Ahmed, Anna M. Brown, Samantha J. Eagle, Evan L. Brittain, Anna R. Hemnes, Rachel T. Sullivan, Eric D. AustinMeharry Medical College School of Medicine. Vanderbilt University Medical Center and Monroe Carell Jr. Children’s Hospital. United States Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70375 AbstractHereditary hemorrhagic telangiectasia (HHT) is an autosomal‑dominant vascular disease characterized by telangiectasias

A Case of High Pressure and High Stakes: Pulmonary Arterial Hypertension Emergence in an Infant With Hereditary Hemorrhagic Telangiectasia Read More »

The NLRP3 Inflammasome Increases Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension

Emmanouil Mavrogiannis, Rebeca Weldeghebreal, Iris R. Schilthuis, Zain K. Fal, Niels J. Kloosterhuis, Mirjam H. Koster, Wim Timens, Johannes M. Douwes, Rolf M. F. Berger, Marit WesterterpBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Netherlands Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70354 AbstractPulmonary arterial hypertension (PAH) is a progressive vasculopathy leading to right-sided

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Iron Homeostasis at High Altitude in Patients With Pulmonary Hypertension

Aurelia E. Reiser, Markus Thiersch, Max Gassmann, Simon R. Schneider, Laura Mayer, Stéphanie Saxer, Michael Furian, Richard Sparla, Esther I. Schwarz, Mona Lichtblau, Martina U. Muckenthaler, Silvia UlrichUniversity of Zürich and University Hospital of Zurich. Eastern Switzerland University of Applied Sciences. University of Heidelberg. Switzerland and Germany Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70352 AbstractIron deficiency

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The Role of Piezo Ion Channels in Pulmonary Hypertension

Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong DuChildren’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Second Affiliated Hospital and School of Medicine of Zhejiang University. China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70360

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Long-Term Postoperative Outcomes of Sinus Venosus Defect

Mariama Touray, Magalie Ladouceur, Judith Bouchardy, Markus Schwerzmann, Matthias Greutmann, Daniel Tobler, Reto Engel, Harald Gabriel, Caroline Blanche, Etienne Pruvot, Nicole Sekarski, Tobias RutzLausanne University Hospital, University of Lausanne. Hôpital Européen Georges Pompidou, Hôpitaux de Paris and Paris-Saclay University. University Hospitals of Geneva. University of Bern. University of Zurich. University Hospital of Basel and University

Long-Term Postoperative Outcomes of Sinus Venosus Defect Read More »

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