Mariama Touray, Magalie Ladouceur, Judith Bouchardy, Markus Schwerzmann, Matthias Greutmann, Daniel Tobler, Reto Engel, Harald Gabriel, Caroline Blanche, Etienne Pruvot, Nicole Sekarski, Tobias Rutz
Lausanne University Hospital, University of Lausanne. Hôpital Européen Georges Pompidou, Hôpitaux de Paris and Paris-Saclay University. University Hospitals of Geneva. University of Bern. University of Zurich. University Hospital of Basel and University of Basel. Kantonsspital St. Gallen. Vienna General Hospital and Medical University of Vienna.
Switzerland, France and Austria
Journal of Clinical Medicine
J Clin Med 2026; 15:
DOI: 10.3390/jcm15145472
Abstract
Background/Objectives: Despite advances in transcatheter therapy, surgery remains the gold standard treatment for sinus venosus defect (SVD). However, data on long-term outcomes following surgical repair remain scarce. This multicenter study evaluates the long-term outcomes of surgically treated SVD patients with comparison to surgically and percutaneously treated secundum atrial septal defect (ASD).
Methods: Clinical, surgical, imaging and invasive data were retrospectively reviewed from eight centers in Europe.
Results: A total of 209 patients were included, of whom 80 were surgically treated SVD, 57 surgically treated secundum ASD and 72 percutaneously treated secundum ASD. Operation for SVD mainly occurred in adulthood, with a median age of 28.5 years (2-68 years). During follow-up, the observed reoperation rate was higher in the SVD cohort than ASD cohorts (p = 0.033), despite shorter follow-up period in the SVD cohort. Reoperations, in the SVD cohort, occurred at a median of 28 years (1-50 years) after index surgery. The need for pacemaker implantation was similar between groups (p = 0.301). The prevalence of late atrial fibrillation did not differ between groups (p = 0.588). Surgically treated SVD tended to have a higher prevalence of atrial flutter and atrial tachycardia, with a significantly higher rate of electrophysiological studies than percutaneously treated secundum ASD (p = 0.013), similar to surgically treated secundum ASD (p = 0.405).
Conclusions: Long-term follow-up of surgically treated SVD is essential to monitor for reintervention and arrhythmic complications.
Category
Class I. Pulmonary Hypertension Associated with Congenital Cardiovascular Disease
Age Focus: Pediatric Pulmonary Vascular Disease or Adult Pulmonary Vascular Disease
Fresh or Filed Publication: Fresh (PHresh). Less than 1-2 years since publication
Article Access
Free PDF File or Full Text Article Available Through PubMed or DOI: Yes