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Cardiac Remodeling Patterns in Pediatric and Adolescent Patients with Sickle Cell Disease and Their Association with the Genotype and Clinical Severity of the Disease: A Systematic Review

Alam Eldin M. Mustafa, Niemat Mohammed Tahir AliKing Khalid University. University of Kordofan.Saudi Arabia and Sudan HealthcareHealthcare 2026; 14:DOI: 10.3390/healthcare14142180 AbstractBackground: Sickle cell disease (SCD) is the most common inherited blood disorder globally, affecting approximately 300,000 newborns annually. Cardiac remodeling, resulting from chronic anemia, vascular obstruction, and endothelial dysfunction, substantially contributes to morbidity and mortality in patients

Cardiac Remodeling Patterns in Pediatric and Adolescent Patients with Sickle Cell Disease and Their Association with the Genotype and Clinical Severity of the Disease: A Systematic Review Read More »

Performance of the Occlutech® Atrial Flow Regulator Device in Patients With Either Failing Fontan Circulations or Irreversible Pulmonary Hypertension

Mehmet Kucuk, Jenny E. Zablah, Gregory Fleming, Dennis Vanloozen, Oliver Aregullin, Konstantin Averin, Mark H. Hoyer, Mark A. Law, James A. Kuo, Ryan Leahy, Christopher Iskander, Gareth J. MorganChildren’s Hospital Colorado. Duke University Medical Center. Cook Children’s Medical Center. Spectrum Health Helen DeVos Children’s Hospital. Cohen Children’s Medical Center. Riley Hospital for Children and Indiana

Performance of the Occlutech® Atrial Flow Regulator Device in Patients With Either Failing Fontan Circulations or Irreversible Pulmonary Hypertension Read More »

Misdiagnosed as Idiopathic PAH: Methylmalonic Acidemia as a Reversible Cause of Pediatric Pulmonary Hypertension

Yan Wu, Yuan-Rui Deng, Xiao-Pei Cui, Sheng-Song Zhu, Jiang Shan Tan, Song Hu, Lu HuaFuwai Hospital, Fuwai Shenzhen Hospital and Peking Union Medical College. Qilu Hospital of Shandong University. China Journal of Heart and Lung TransplantationJ Heart Lung Transplant 2026; DOI: 10.1016/j.healun.2026.07.021 AbstractBackground: Methylmalonic acidemia (MMA)-induced pulmonary hypertension (PH) is a rare but treatable cause of pediatric

Misdiagnosed as Idiopathic PAH: Methylmalonic Acidemia as a Reversible Cause of Pediatric Pulmonary Hypertension Read More »

Variability in the Diagnostic Criteria for Severe Pertussis: A Systematic Review

Pauline Labe, Alexandre Meunier. Pauline Leroux, Mirko Sadi, Carla Rodrigues, Valerie Bouchez, Marion Grimaud, Sylvain Brisse, Jérémie F. Cohen, Julie ToubianaUniversité Paris Cité, Institut Pasteur and Hôpital Necker-Enfants Malades. France Journal of the American Medical Association Network OpenJAMA Netw Open 2026; 9:DOI: 10.1001/jamanetworkopen.2026.22211 AbstractImportance: Pertussis, or whooping cough, can be life threatening in infants, yet the concept

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Multimodal imaging of infantile scimitar syndrome with Eisenmenger physiology: A case report of complex intracardiac and extracardiac shunts

Berihu Gebre, Yirgalem Gereziher, Catherine Alcober, Gladys Baltazar, Viachaslau MarkauNauru Medical Center. Mekelle University.Republic of Nauru and Ethiopia Radiology Case ReportsRadiol Case Rep 2026; 21: 4642-4650DOI: 10.1016/j.radcr.2026.06.141 AbstractScimitar syndrome is a rare congenital vascular malformation in which the right pulmonary veins drain abnormally into the inferior vena cava, right atrium, or portal vein instead of the

Multimodal imaging of infantile scimitar syndrome with Eisenmenger physiology: A case report of complex intracardiac and extracardiac shunts Read More »

Meta-analysis of prostacyclin therapy for persistent pulmonary hypertension with congenital diaphragmatic hernia

Shouliang Jiang, Xue Han, Yang He, Qian Gao, Juan Liang, Tingting Zhu, Li Zhang, Jun TangWest China Second University Hospital and Sichuan University. China Journal of Pediatric SurgeryJ Pediatr Surg 2026; DOI: 10.1016/j.jpedsurg.2026.163301 AbstractObjective: To evaluate the efficacy and safety of prostacyclin in the treatment of persistent pulmonary hypertension in congenital diaphragmatic hernia.Methods: A systematic literature search was

Meta-analysis of prostacyclin therapy for persistent pulmonary hypertension with congenital diaphragmatic hernia Read More »

Targeted Flow Cardiac MRI in Neonates with Intracardiac Shunts: A Novel Multi-Modality Imaging Approach to Hemodynamic Assessment

Charles T. Simpkin, Anne C. Taylor, Jessica MacLean, Michael Cookson, Richard Friesen, Emily Downs, D. Dunbar Ivy, Cesar Gonzalez de Alba, Benjamin S. FrankUniversity of Colorado Medical Campus and Children’s Hospital Colorado.United States Journal of PediatricsJ Pediatr 2026; DOI: 10.1016/j.jpeds.2026.115261 AbstractDistinguishing the relative contributions of pulmonary vascular resistance and intracardiac shunts to elevated right-heart pressures in

Targeted Flow Cardiac MRI in Neonates with Intracardiac Shunts: A Novel Multi-Modality Imaging Approach to Hemodynamic Assessment Read More »

Metabolic reprogramming in pulmonary arterial hypertension

Jun-Zhuo Shi, Jing-Song Ye, Xiao-Rui An, Guo Cheng, Xin Fan, Fang-Fang Meng, Ou Yang, Yang-Han-Yue Zhou, Meng-Jie Zhang, Tian-Yi Yuan, Yi Yan, Yang-Yang HeHuaihe Hospital and Henan University. Shanghai Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Chinese Academy of Medical Sciences and Peking Union Medical College. Pharmacology and TherapeuticsPharmacol Ther 2026;

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Intra- and Peri-Operative Cardiac Arrest in Pediatric Patients: Epidemiology, Risk Factors, Mechanisms, and Management Strategies

Eleni Asimacopou;os, Gloria M. Al Karaki, Kirsten C. OdegardBoston Children’s Hospital.United States Paediatric AnaesthesiaPaediatr Anaesth 2026; DOI: 10.1002/pan.70265 AbstractIntraoperative (IOCA) and perioperative cardiac arrest (POCA) in pediatric patients represents a rare but catastrophic event with significant implications for morbidity and mortality. Despite advances in anesthetic techniques, monitoring technology, and resuscitation protocols, the incidence of IOCA and

Intra- and Peri-Operative Cardiac Arrest in Pediatric Patients: Epidemiology, Risk Factors, Mechanisms, and Management Strategies Read More »

Respiratory-Related Hospital Admissions in Children and Young Adults With Down Syndrome

Emily DeBoer, Kristine Wolter-Warmerdam, Rebecca Bernstein, Arwen Jackson, Jennifer Maybee, Karen Kelminson, Francis HickeyUniversity of Colorado and Children’s Hospital Colorado.United States Hospital Pediatrics Hosp Pediatr 2026; DOI: 10.1542/hpeds.2025-008731 AbstractBackground: Children with Down syndrome (DS) have an increased risk for hospitalization and intensive care owing to respiratory illnesses; however, current research does not specify which co-occurring diagnoses increase

Respiratory-Related Hospital Admissions in Children and Young Adults With Down Syndrome Read More »

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