Class 1. Persistent Pulmonary Hypertension of the Newborn

Persistent Pulmonary Hypertension Among Infants Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy: A Systematic Review and Meta-Analysis

Rashida Javed, Tim J. Van Hasselt, Narasimha Rao, Harsha GowdaNorthampton General Hospital. University of Leicester. Madinat Zayed Hospital. University Hospitals Birmingham.United Kingdom and United Arab Emiretes Therapeutic Hypothermia and Temperature ManagementTher Hypothermia Temp Manag 2025; DOI: 10.1177/21537658251370950 AbstractTo perform a systematic review and meta-analysis to examine the association between persistent pulmonary hypertension (PPHN) and receipt of […]

Persistent Pulmonary Hypertension Among Infants Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy: A Systematic Review and Meta-Analysis Read More »

Clinical Characteristics and Outcomes for Neonates with Respiratory Failure Referred for Extracorporeal Membrane Oxygenator (ECMO) Support

Pooja Musuku, Keith Meyer, Felipe E. Pedroso, Fuad Alkhoury, Balagangadhar R. TotapallyNicklaus Children’s Hospital. Herbert Wertheim College of Medicine and Florida International University.United States ChildrenChildren 2025; 12: DOI: 10.3390/children12070925 AbstractObjective: The aim of this study was to describe the presenting characteristics and outcomes of neonates with respiratory failure referred for extracorporeal membrane oxygenation (ECMO) support, compare

Clinical Characteristics and Outcomes for Neonates with Respiratory Failure Referred for Extracorporeal Membrane Oxygenator (ECMO) Support Read More »

Giant Omphalocele: Systematic Review of Pulmonary Complications and Implications for Neonatal Care

Joana Peixoto, Joana Neto, Susana Pissarra, Inês Azevedo, Henrique Soares, Gustavo RochaUniversidade do Porto. Centro Hospitalar Universitário de São João. Portugal European Journal of Pediatric SurgeryEur J Pediatr Surg 2025; DOI: 10.1055/a-2649-0781 AbstractThe primary objectives were to know the prevalences of pulmonary hypoplasia (PH), persistent pulmonary hypertension of the newborn (PPHN), and mortality in newborn infants

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Persistent Pulmonary Hypertension of the Newborn in Very Low Birth Weight Infants: Risk Factors and Clinical Outcomes from a Matched Case-Control Study

Anucha Thatrimontrichai, Pattima Pakhathirathien, Manapat Praditaukrit, Gunlawadee Maneenil, Supaporn Dissaneevate, Ploypailin Jantarawongpisal, Jenjira SaechanPrince of Songkla University.Thailand Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14134759 AbstractBackground/Objectives: To identify the risk factors and clinical outcomes of persistent pulmonary hypertension of the newborn (PPHN) in very low birth weight (VLBW) infants in a resource-limited setting. Methods: We

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Mortality Risk Factors and Survival Outcomes in Infants with Persistent Pulmonary Hypertension of the Newborn

Kokaew Chuaikaew, Gunlawadee Maneenil, Anucha Thatrimontrichai, Supaporn Dissaneevate, Manapat PraditaukritPrince of Songkla University.Thailand Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14134502 AbstractBackground/Objectives: Persistent pulmonary hypertension of the newborn (PPHN) is characterized by increased pulmonary vascular resistance, resulting in severe hypoxemia. This study determined the factors associated with increased risk of mortality and survival rate

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Comparison of the oxygenation index and the oxygen saturation index as clinical indicators for neonatal ECMO

John Slaughter, Jeremy Sites, Hubert Ballard, John Bauer, Aric Schadler, Nicholas SeverynUniversity of Kentucky College of Medicine. United States Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1586985 AbstractIntroduction: Neonatal hypoxic respiratory failure is commonly assessed with the oxygenation index (OI) to determine severity and guide ECMO initiation. Calculation of the OI requires arterial blood sampling which can

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Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy

Chaohong Chen, Zaoye Xie, DangAo, Yinhui Chen, Ling Liu, Chengyan LiAffiliated Hospital of Guangdong Medical University. China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-07068-5 AbstractPersistent pulmonary hypertension of the newborn (PPHN) represents a life-threatening cardiopulmonary condition characterized by hypoxia-driven pulmonary vascular remodeling. While transcription factor EB (TFEB), a master regulator of cellular adaptation to hypoxia, has

Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy Read More »

Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn

Matthew D. Durbin, David G. Tingay, Kok Lim KuaIndiana University School of Medicine. Murdoch Children’s Research Institute and University of Melbourne.United States and Australia Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04234-3 AbstractAbstract Not Available CategoryClass I. Persistent Pulmonary Hypertension of the NewbornAnimal Models of Pulmonary Vascular Disease and TherapyVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseGenetic

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Incidence and clinical predictors of hyper-direct bilirubinemia in preterm infants without underlying disease

Takuya Akimoto, Nobuhiko Nagano, Yuki Sato, Hidetoshi Go, Koichiro Hara, Takayuki Imaizumi, Ryoji Aoki, Midori Hijikata, Aya Okahashi, Ichiro MoriokaNihon University School of Medicine. Japan Pediatrics InternationalPediatr Int 2025; DOI: 10.1111/ped.70026 AbstractBackgrounds: This study aimed to identify the incidence and clinical predictors of hyper-direct bilirubinemia (hyper-DB) in preterm infants without underlying diseases.Methods: We enrolled neonates born at <34

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Co-Occurring Medical Conditions in Over 2300 Children With Down Syndrome at a Down Syndrome Multispecialty Clinic

Francis Hickey, Liz Maastricht, Kristine Wolter-Warmerdam, Dee Daniels, Bailey Herfindahl, Karen KelminsonUniversity of Colorado School of Medicine, Aurora and Children’s Hospital Colorado.United States Journal of Intellectual Disability ResearchJ Intelect Dis Res 2025;DOI: 10.1111/jir.13257 AbstractBackground: Children with Down syndrome (DS) have an increased frequency of co-occurring medical complications compared to the typically developing population; however, incidence rates of

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