Class 1. Persistent Pulmonary Hypertension of the Newborn

Phenotyping persistent pulmonary hypertension of the newborn: recognition of its persistence across world symposium on pulmonary hypertension classifications

Stephanie M. Tsoi, Philip T. Levy, Steven H. Abman, Nidhy P. VargheseBenioff Children’s Hospital and University of California, San Francisco. Harvard Medical School and Boston Children’s Hospital. University of Colorado Anschutz Medical School and Children’s Hospital Colorado. Baylor College of Medicine and Texas Children’s Hospital.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02704-y AbstractThe earliest clinical

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Plasma Asymmetric Dimethylarginine as a Biomarker of Disease Severity and Therapeutic Response in Neonatal Persistent Pulmonary Hypertension: An Observational Prospective Case-Control Study

Rania M Abdou, Maged A. El Wakeel, Ghada M. El-Kassas, Walaa H. Ali, Hend M. Ahmed, Mohamed Agha, Mohamed Abdel Atti Abdel Fatah, Ramy Saleh Abdelghany, Kareem Salah Eldin Fekry Madbouly, Haidy Badei Mohamad, Iman Shawky Hassan, Mohamed Abdelsalam Mohamed Ahmed, Heba T. Okda, Hatem Attia Mostafa Ismail Ain Shams University. Child Health Department, National

Plasma Asymmetric Dimethylarginine as a Biomarker of Disease Severity and Therapeutic Response in Neonatal Persistent Pulmonary Hypertension: An Observational Prospective Case-Control Study Read More »

Prognostic value of haemodynamic and neurophysiological assessments in newborns with hypoxic-ischaemic encephalopathy undergoing whole-body therapeutic hypothermia: a systematic review and meta-analysis of short-term outcomes

Mona Noureldein, Vincent So, Lamia Hayawi, Ayman Saker, Laurent Renesme, Anne Tsampalieros, Nadya Ben FadelBirmingham Heartlands Hospital and University Hospitals Birmingham NHS Foundation Trust. Children’s Hospital of Eastern Ontario. University of Ottawa.United Kingdom and Canada Archives of Disease in Childhood Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2026; DOI: 10.1136/archdischild-2025-329322 AbstractObjective: To evaluate the prognostic

Prognostic value of haemodynamic and neurophysiological assessments in newborns with hypoxic-ischaemic encephalopathy undergoing whole-body therapeutic hypothermia: a systematic review and meta-analysis of short-term outcomes Read More »

Clinical profile, survival outcomes, and predictors of mortality in neonates with persistent pulmonary hypertension: a follow-up study from Hawassa, Ethiopia

Mohammed Nasir, Mihiretu AhmedHawassa University. Bushulo Mother to Child Center.Ethiopia BioMedical Central PediatricsBMC Pediatr 2026; DOI: 10.1186/s12887-026-06904-5 AbstractIntroduction: Persistent pulmonary hypertension of the newborn (PPHN) is a failure of normal fetal-to-neonatal circulatory transition. Evidence from low-resource settings remains limited. This study evaluated clinical characteristics, treatment outcomes, mortality predictors, and time to clinical and echocardiographic resolution among

Clinical profile, survival outcomes, and predictors of mortality in neonates with persistent pulmonary hypertension: a follow-up study from Hawassa, Ethiopia Read More »

Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension

Sarah M. Nofal, Abdel‑Rahman M. El‑Mashad, Asmaa M. Elmesiry, Amany M. Abouelenain, Mostafa M. AwnyTanta University.Egypt European Journal of PediatricsEur J Pediatr 2026; 185: DOI: 10.1007/s00431-026-06864-z AbstractThe aim of this study is to investigate the effects of melatonin on the left ventricular (LV) function in persistent pulmonary hypertension of the newborn (PPHN) and to assess its

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Utility of Echocardiography in 173 VA ECMO Clamp Trials in Babies and Children

Kevin L. Smith, David W. Liddle, Mary Sciff, K. T. Fishbein, Rod Ghassemzadeh, Brian Feingold, Laura J. OlivieriChildren’s National Medical Center. University of Pittsburgh Children’s Hospital of Pittsburgh and University of Pittsburgh.United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04245-9 AbstractVenoarterial extracorporeal membrane oxygenation (VA ECMO) offers vital support to children with cardiopulmonary failure. Echocardiography is commonly

Utility of Echocardiography in 173 VA ECMO Clamp Trials in Babies and Children Read More »

Lung ultrasound score ≥ 6 predicts surfactant administration decisions in meconium aspiration syndrome: a multicenter prospective study

Qi Chen, Zekai Yu, Lei Cao, Wei Xiong, Mei Zheng, Fei Wang, Shasha Wu, Rijin Yu, Minli Zhou, Cheng Guo, Lin Dong, Shuang LiuShangrao Children’s Hospital and Shangrao Maternal and Child Health Hospital. Hangzhou Dianzi University. Jingdezhen First People’s Hospital. Hubei University of Medicine. Xiangyang First People’s Hospital. Qinghai Red Cross Hospital. Yangzhou Maternal and

Lung ultrasound score ≥ 6 predicts surfactant administration decisions in meconium aspiration syndrome: a multicenter prospective study Read More »

Decreased AMP-Kinase Function in Pulmonary Artery Smooth Muscle Cells Contributes to Pulmonary Artery Remodeling in Persistent Pulmonary Hypertension of Newborn

Emily A. Mooers, Ujala Rana, Chintamani N. Joshi, Adeleye J. Afolayan, Ru-Jeng Teng, Girija Ganesh KonduriMedical College of Wisconsin. United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00229.2025 AbstractPulmonary vascular remodeling contributes to Persistent Pulmonary Hypertension of the Newborn (PPHN); the mechanisms remain unknown. 5’AMP-Activated

Decreased AMP-Kinase Function in Pulmonary Artery Smooth Muscle Cells Contributes to Pulmonary Artery Remodeling in Persistent Pulmonary Hypertension of Newborn Read More »

Prevalence and severity of persistent pulmonary hypertension of the newborns among asphyxiated neonates admitted in Enugu State University Teaching Hospital

Ani Okechukwu, Odutola Odetunde, Ekwochi Uchenna, Josephat M ChinawaEnugu State University College of Medicine. University of Nigeria Teaching Hospital Ituku/Ozalla and University of Nigeria ItukuNigeria British Medical Journal Paediatrics OpenBMJ Paediatr Open 2026; 10: DOI: 10.1136/bmjpo-2025-004351 AbstractBackground: Persistent pulmonary hypertension of newborns (PPHN) is an acute neonatal disorder with a high mortality rate despite several advances in

Prevalence and severity of persistent pulmonary hypertension of the newborns among asphyxiated neonates admitted in Enugu State University Teaching Hospital Read More »

Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study

Yao Zhu, Jiongzhi He, Miner Cai, Lijun Wen, Minxu LiDongguan Maternal and Child Health Care Hospital. First Affiliated Hospital of Jinan University.China Translational PediatricsTransl Pediatr 2025; 14: 3305-3317DOI: 10.21037/tp-2025-535 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening emergency in neonatal intensive care. Traditional treatments such as cylinder-based nitric oxide (NO) delivery systems rely on

Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study Read More »

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