Class 1. Persistent Pulmonary Hypertension of the Newborn Archives

Clinical profile, survival outcomes, and predictors of mortality in neonates with persistent pulmonary hypertension: a follow-up study from Hawassa, Ethiopia

Mohammed Nasir, Mihiretu AhmedHawassa University. Bushulo Mother to Child Center.Ethiopia BioMedical Central PediatricsBMC Pediatr 2026; DOI: 10.1186/s12887-026-06904-5 AbstractIntroduction: Persistent pulmonary hypertension of the newborn (PPHN) is a failure of normal fetal-to-neonatal circulatory transition. Evidence from low-resource settings remains limited. This study evaluated clinical characteristics, treatment outcomes, mortality predictors, and time to clinical and echocardiographic resolution among […]

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Melatonin effects on the left ventricular function in neonates with persistent pulmonary hypertension

Sarah M. Nofal, Abdel‑Rahman M. El‑Mashad, Asmaa M. Elmesiry, Amany M. Abouelenain, Mostafa M. AwnyTanta University.Egypt European Journal of PediatricsEur J Pediatr 2026; 185: DOI: 10.1007/s00431-026-06864-z AbstractThe aim of this study is to investigate the effects of melatonin on the left ventricular (LV) function in persistent pulmonary hypertension of the newborn (PPHN) and to assess its

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Utility of Echocardiography in 173 VA ECMO Clamp Trials in Babies and Children

Kevin L. Smith, David W. Liddle, Mary Sciff, K. T. Fishbein, Rod Ghassemzadeh, Brian Feingold, Laura J. OlivieriChildren’s National Medical Center. University of Pittsburgh Children’s Hospital of Pittsburgh and University of Pittsburgh.United States Pediatric CardiologyPediatr Cardiol 2026; DOI: 10.1007/s00246-026-04245-9 AbstractVenoarterial extracorporeal membrane oxygenation (VA ECMO) offers vital support to children with cardiopulmonary failure. Echocardiography is commonly

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Lung ultrasound score ≥ 6 predicts surfactant administration decisions in meconium aspiration syndrome: a multicenter prospective study

Qi Chen, Zekai Yu, Lei Cao, Wei Xiong, Mei Zheng, Fei Wang, Shasha Wu, Rijin Yu, Minli Zhou, Cheng Guo, Lin Dong, Shuang LiuShangrao Children’s Hospital and Shangrao Maternal and Child Health Hospital. Hangzhou Dianzi University. Jingdezhen First People’s Hospital. Hubei University of Medicine. Xiangyang First People’s Hospital. Qinghai Red Cross Hospital. Yangzhou Maternal and

Lung ultrasound score ≥ 6 predicts surfactant administration decisions in meconium aspiration syndrome: a multicenter prospective study Read More »

Decreased AMP-Kinase Function in Pulmonary Artery Smooth Muscle Cells Contributes to Pulmonary Artery Remodeling in Persistent Pulmonary Hypertension of Newborn

Emily A. Mooers, Ujala Rana, Chintamani N. Joshi, Adeleye J. Afolayan, Ru-Jeng Teng, Girija Ganesh KonduriMedical College of Wisconsin. United States American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00229.2025 AbstractPulmonary vascular remodeling contributes to Persistent Pulmonary Hypertension of the Newborn (PPHN); the mechanisms remain unknown. 5’AMP-Activated

Decreased AMP-Kinase Function in Pulmonary Artery Smooth Muscle Cells Contributes to Pulmonary Artery Remodeling in Persistent Pulmonary Hypertension of Newborn Read More »

Prevalence and severity of persistent pulmonary hypertension of the newborns among asphyxiated neonates admitted in Enugu State University Teaching Hospital

Ani Okechukwu, Odutola Odetunde, Ekwochi Uchenna, Josephat M ChinawaEnugu State University College of Medicine. University of Nigeria Teaching Hospital Ituku/Ozalla and University of Nigeria ItukuNigeria British Medical Journal Paediatrics OpenBMJ Paediatr Open 2026; 10: DOI: 10.1136/bmjpo-2025-004351 AbstractBackground: Persistent pulmonary hypertension of newborns (PPHN) is an acute neonatal disorder with a high mortality rate despite several advances in

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Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study

Yao Zhu, Jiongzhi He, Miner Cai, Lijun Wen, Minxu LiDongguan Maternal and Child Health Care Hospital. First Affiliated Hospital of Jinan University.China Translational PediatricsTransl Pediatr 2025; 14: 3305-3317DOI: 10.21037/tp-2025-535 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening emergency in neonatal intensive care. Traditional treatments such as cylinder-based nitric oxide (NO) delivery systems rely on

Safety of a novel portable inhaled nitric oxide generator for therapy of persistent pulmonary hypertension in neonates: a case series study Read More »

Clinical impact of treprostinil in neonates with persistent pulmonary hypertension refractory to inhaled nitric oxide: A retrospective cohort study

Tae Hyeong Kim, Song Ee Youn, Sung-Hoon ChungKyung Hee University College of Medicine and Kyung Hee University Hospital at Gangdong.Republic of Korea MedicineMedicine 2026; 105: DOI: 10.1097/MD.0000000000046984 AbstractPersistent pulmonary hypertension of the newborn (PPHN) has limited options when unresponsive to inhaled nitric oxide (iNO). We evaluated the role of intravenous treprostinil and whether early response classification

Clinical impact of treprostinil in neonates with persistent pulmonary hypertension refractory to inhaled nitric oxide: A retrospective cohort study Read More »

Neonatologist-Performed Echocardiography in Neonatal Pulmonary Hypertension: A Narrative Review of the Literature

Anna Chiara Titolo, Mandy Ferrocino, Eleonora Biagi, Luisa Rizzo, Hajrie Seferi, Valentina Dell’Orto, Serafina Perrone, Susanna EspositoParma University Hospital and University of Parma.Italy DiagnosticsDiagnostics 2025; 15: DOI: 10.3390/diagnostics15243154 AbstractNeonatal pulmonary hypertension (PH) is a major cause of illness and death in newborns. Neonatologist-performed echocardiography (NPE) is increasingly used as a bedside tool to assess heart function,

Neonatologist-Performed Echocardiography in Neonatal Pulmonary Hypertension: A Narrative Review of the Literature Read More »

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study

Feng Xie, Philip Chung, Jonathan D. Reiss, Erico Tjoa, Davide De Francesco, Thanaphong Phongpreecha, William Haberkorn, Dipro Chakraborty, Alan Lee Chang, Tomin James, Yeasul Kim, Samson Mataraso, Camilo Espinosa, Liu Yang, Chi-Hung Shu, Lei Xue, Eloïse Berson, Neshat Mohammadi, Sayane Shome, S Momsen Reincke, Marc Ghanem, Ivana Maric, Brice Gaudilliere, Martin S Angst, Karl Sylvester,

Development and validation of a pre-trained language model for neonatal morbidities: a retrospective, multicentre, prognostic study Read More »