Class 1. Persistent Pulmonary Hypertension of the Newborn

Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies

Srirupa Hari Gopal, Shweta Parmekar, Eugene Dempsey, Mohan PammiSSM Health Cardinal Glennon Children’s Hospital and Saint Louis University. Baylor College of Medicine and Texas Children’s Hospital.  University College Cork.United States and Ireland Pediatric ResearchPediatr Res 2026; DOI: 10.1038/s41390-026-05164-4 AbstractWith improving survival, periviable neonates (≤25 weeks’ gestation) represent a dynamic, but under-studied population in neonatal care, with […]

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Physician Perspectives on the Utility of Pre/Post-Ductal Oxygen Saturation Monitoring in the Management of Neonates With Congenital Heart Disease

Beau Redwood, Adrian Tarca, Zac Dempsey, Rebecca Thomas, Cameron Seaman, Simon Erickson, Stephen Shipton, Deane YimPerth Children’s Hospital. Kids Research Institute Australia. Australia Heart Lung and CirculationHeart Lung Circ 2026; DOI: 10.1016/j.hlc.2025.12.028 AbstractBackground: Simultaneous pre/post-ductal oxygen saturation measurements are routinely performed in neonates with suspected congenital heart disease (CHD) however, there is significant variability in physician practices

Physician Perspectives on the Utility of Pre/Post-Ductal Oxygen Saturation Monitoring in the Management of Neonates With Congenital Heart Disease Read More »

Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea

Ji Yoo Kim, Hyeon Jin Kim, Heeyoon Choi, Minji Kim, Jinseok Lee, Yong Sung Choi, Dong Keon YonKyung Hee University Medical Center and Kyung Hee University College of Medicine. South Korea Clinical and Experimental PediatricsClin Exp Pediatr 2026; DOI: 10.3345/cep.2025.02817 AbstractBackground: The impact of metabolic acidosis on short-term outcomes and mortality in very low birth weight infants

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Neonatal cyanosis: exploring the complexity of coexisting congenital methemoglobinaemia and pulmonary hypertension

Kayla Sliskovic, Abdullah Aljughaiman, Ahmed Al Farsi, Anita Cheng, Soume BhattacharyWestern University.Canada British Medical Journals Case ReportsBMJ Case Rep 2026; DOI: 10.1136/bcr-2025-271784 AbstractNeonatal cyanosis is commonplace, usually from respiratory or cardiac causes. Consideration of alternative or combined aetiologies was required when a 3-hour-old term male neonate with central cyanosis, low oxygen saturation (SpO2), and persistent pulmonary hypertension of

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Descriptive study of the effects of treprostinil and/or epoprostenol in newborn infants with inhaled NO refractory persistent pulmonary hypertension of the newborn (PPHN)

Charlotte Mazepa, Sébastien Mur, Géraldine Gascoind, Laurent Storme, Nicolas Joram, Caroline Viard, Yves Dulac, Marine Butini, Sophie BreinigChildren’s Hospital, CHU de Toulouse and Université de Toulouse. Lille University Hospital. Jeanne-de-Flandre Hospital and CHU de Lille. Nantes University Hospital. Hôpital Femme-Mère-Enfant, Hospices civils de Lyon and Université Claude-Bernard-Lyon. France TherapeuticsTherapie 2026; DOI: 10.1016/j.therap.2026.03.001 AbstractBackground: Epoprostenol and treprostinil, prostacyclin

Descriptive study of the effects of treprostinil and/or epoprostenol in newborn infants with inhaled NO refractory persistent pulmonary hypertension of the newborn (PPHN) Read More »

Hemodynamic effects of high frequency oscillatory ventilation versus conventional mechanical ventilation in term neonates with persistent pulmonary hypertension: a single-center randomized trial

Doaa El Amrousy, Hassan Koura, Noura Abdou, Mostafa Awny, Abdelrahman ElmashadTanta University.Egypt Italian Journal of MedicineItal J Med 2026; 52: DOI: 10.1186/s13052-026-02272-z AbstractBackground: We aimed to evaluate the hemodynamics in full-term neonates with persistent pulmonary hypertension (PPH) on high frequency oscillatory ventilation (HFOV) versus conventional mechanical ventilation (CMV).Methods: This trial was conducted on 64 full-term neonates with PPH

Hemodynamic effects of high frequency oscillatory ventilation versus conventional mechanical ventilation in term neonates with persistent pulmonary hypertension: a single-center randomized trial Read More »

Gap between guidelines and practice: echocardiography reporting in neonatal pulmonary hypertension

Sophia Gremont, Eveliina Ronkainen, Merja KallioUniversity of Oulu. Oulu University Hospital. Helsinki University Hospital, University of Helsinki.Finland Cardiology in the YoungCardiol Young 2026; DOI: 10.1017/S104795112611292X AbstractObjectives: Targeted neonatal echocardiography is increasingly integrated into neonatal care and plays a crucial role in the evaluation and management of persistent pulmonary hypertension of the newborn. The objective of this study

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Phenotyping persistent pulmonary hypertension of the newborn: recognition of its persistence across world symposium on pulmonary hypertension classifications

Stephanie M. Tsoi, Philip T. Levy, Steven H. Abman, Nidhy P. VargheseBenioff Children’s Hospital and University of California, San Francisco. Harvard Medical School and Boston Children’s Hospital. University of Colorado Anschutz Medical School and Children’s Hospital Colorado. Baylor College of Medicine and Texas Children’s Hospital.United States Journal of PerinatologyJ Perinatol 2026; DOI: 10.1038/s41372-026-02704-y AbstractThe earliest clinical

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Plasma Asymmetric Dimethylarginine as a Biomarker of Disease Severity and Therapeutic Response in Neonatal Persistent Pulmonary Hypertension: An Observational Prospective Case-Control Study

Rania M Abdou, Maged A. El Wakeel, Ghada M. El-Kassas, Walaa H. Ali, Hend M. Ahmed, Mohamed Agha, Mohamed Abdel Atti Abdel Fatah, Ramy Saleh Abdelghany, Kareem Salah Eldin Fekry Madbouly, Haidy Badei Mohamad, Iman Shawky Hassan, Mohamed Abdelsalam Mohamed Ahmed, Heba T. Okda, Hatem Attia Mostafa Ismail Ain Shams University. Child Health Department, National

Plasma Asymmetric Dimethylarginine as a Biomarker of Disease Severity and Therapeutic Response in Neonatal Persistent Pulmonary Hypertension: An Observational Prospective Case-Control Study Read More »

Prognostic value of haemodynamic and neurophysiological assessments in newborns with hypoxic-ischaemic encephalopathy undergoing whole-body therapeutic hypothermia: a systematic review and meta-analysis of short-term outcomes

Mona Noureldein, Vincent So, Lamia Hayawi, Ayman Saker, Laurent Renesme, Anne Tsampalieros, Nadya Ben FadelBirmingham Heartlands Hospital and University Hospitals Birmingham NHS Foundation Trust. Children’s Hospital of Eastern Ontario. University of Ottawa.United Kingdom and Canada Archives of Disease in Childhood Fetal and Neonatal EditionArch Dis Child Fetal Neonatal Ed 2026; DOI: 10.1136/archdischild-2025-329322 AbstractObjective: To evaluate the prognostic

Prognostic value of haemodynamic and neurophysiological assessments in newborns with hypoxic-ischaemic encephalopathy undergoing whole-body therapeutic hypothermia: a systematic review and meta-analysis of short-term outcomes Read More »

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