Class 1. Persistent Pulmonary Hypertension of the Newborn

Mortality Risk Factors and Survival Outcomes in Infants with Persistent Pulmonary Hypertension of the Newborn

Kokaew Chuaikaew, Gunlawadee Maneenil, Anucha Thatrimontrichai, Supaporn Dissaneevate, Manapat PraditaukritPrince of Songkla University.Thailand Journal of Clinical MedicineJ Clin Med 2025; 14: DOI: 10.3390/jcm14134502 AbstractBackground/Objectives: Persistent pulmonary hypertension of the newborn (PPHN) is characterized by increased pulmonary vascular resistance, resulting in severe hypoxemia. This study determined the factors associated with increased risk of mortality and survival rate […]

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Comparison of the oxygenation index and the oxygen saturation index as clinical indicators for neonatal ECMO

John Slaughter, Jeremy Sites, Hubert Ballard, John Bauer, Aric Schadler, Nicholas SeverynUniversity of Kentucky College of Medicine. United States Frontiers in PediatricsFront Pediatr 2025; 13: DOI: 10.3389/fped.2025.1586985 AbstractIntroduction: Neonatal hypoxic respiratory failure is commonly assessed with the oxygenation index (OI) to determine severity and guide ECMO initiation. Calculation of the OI requires arterial blood sampling which can

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Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy

Chaohong Chen, Zaoye Xie, DangAo, Yinhui Chen, Ling Liu, Chengyan LiAffiliated Hospital of Guangdong Medical University. China Scientific ReportsSci Rep 2025; 15: DOI: 10.1038/s41598-025-07068-5 AbstractPersistent pulmonary hypertension of the newborn (PPHN) represents a life-threatening cardiopulmonary condition characterized by hypoxia-driven pulmonary vascular remodeling. While transcription factor EB (TFEB), a master regulator of cellular adaptation to hypoxia, has

Transcription factor EB improves hypoxic pulmonary hypertension in fetal rats by suppressing NLRP3 inflammasome activation via induction of mitophagy Read More »

Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn

Matthew D. Durbin, David G. Tingay, Kok Lim KuaIndiana University School of Medicine. Murdoch Children’s Research Institute and University of Melbourne.United States and Australia Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04234-3 AbstractAbstract Not Available CategoryClass I. Persistent Pulmonary Hypertension of the NewbornAnimal Models of Pulmonary Vascular Disease and TherapyVascular Cell Biology and Mechanisms of Pulmonary Vascular DiseaseGenetic

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Incidence and clinical predictors of hyper-direct bilirubinemia in preterm infants without underlying disease

Takuya Akimoto, Nobuhiko Nagano, Yuki Sato, Hidetoshi Go, Koichiro Hara, Takayuki Imaizumi, Ryoji Aoki, Midori Hijikata, Aya Okahashi, Ichiro MoriokaNihon University School of Medicine. Japan Pediatrics InternationalPediatr Int 2025; DOI: 10.1111/ped.70026 AbstractBackgrounds: This study aimed to identify the incidence and clinical predictors of hyper-direct bilirubinemia (hyper-DB) in preterm infants without underlying diseases.Methods: We enrolled neonates born at <34

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Co-Occurring Medical Conditions in Over 2300 Children With Down Syndrome at a Down Syndrome Multispecialty Clinic

Francis Hickey, Liz Maastricht, Kristine Wolter-Warmerdam, Dee Daniels, Bailey Herfindahl, Karen KelminsonUniversity of Colorado School of Medicine, Aurora and Children’s Hospital Colorado.United States Journal of Intellectual Disability ResearchJ Intelect Dis Res 2025;DOI: 10.1111/jir.13257 AbstractBackground: Children with Down syndrome (DS) have an increased frequency of co-occurring medical complications compared to the typically developing population; however, incidence rates of

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Efficacy of Intravascular Therapeutic Hypothermia for Moderate to Severe Hypoxic-Ischemic Encephalopathy

Tomonori Kurimoto, Takuya Tokuhisa, Itaru Hayasaka, Tsuyoshi Yamamoto, Eiji Hirakawa, Hiroshi Ohashi, Masaya Kibe, Asataro Yara, Takatsugu Maeda, Masato Kamitomo, Satoshi IbaraKagoshima City Hospital. Nikko Memorial Hospital. Japan ChildrenChildren 2025; 12: DOI: 10.3390/children12050605 AbstractBackground/objectives: Hypoxic-ischemic encephalopathy (HIE), affecting 1.3-1.7/1000 live births, is treated with conventional therapeutic hypothermia (TH) but carries significant mortality and neurological impairment. Here, we

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Comparative study between nebulized and intravenous magnesium sulfate for treatment of persistent pulmonary hypertension in neonates

Nashwa Farouk Mohamed, Osama Abu El Fetouch Zaki El Feky, Heba Morsy Saad El Din El Ganady, Walid Abd Elatif Abd El HalimBenha University.Egypt Journal of Neonatal-Perinatal MedicineJ Neonatal Perinatal Med 2025; 18: 246-254DOI: 10.1177/19345798251325510 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening condition resulting from elevated pulmonary vascular resistance, causing severe hypoxemia.

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Decreased endothelial micro-RNA-30b-5p impairs angiogenesis in fetal lambs with persistent pulmonary hypertension

Sunil K. Sati, Ujala Rana, Chintamani Joshi, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2025; DOI: 10.1038/s41390-025-04098-7 AbstractBackground: Impaired angiogenesis contributes to increased pulmonary vascular resistance in persistent pulmonary hypertension of the newborn (PPHN). Notch signaling, critical to lung angiogenesis, is modulated by micro-RNAs (miR). RNA sequencing of pulmonary arterial endothelial cells

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Persistent pulmonary hypertension of the newborn infant (PPHN) due to premature closure of the ductus arteriosus (DA)

Ayevbekpen Grace Okoye, Adrita Khawash, Mahesh Nanjundappa, Matthew Jones, Anne GreenoughKings College Hospital NHS Foundation Trust. Evelina Children’s Hospital and Guys and St Thomas Hospital. United Kingdom Case Reports in Perinatal MedicineCase Rep Perinat Med 2025; 13: DOI: 10.1515/crpm-2024-0001 AbstractObjectives: To describe the course of an infant with persistent pulmonary hypertension of the newborn (PPHN) secondary to

Persistent pulmonary hypertension of the newborn infant (PPHN) due to premature closure of the ductus arteriosus (DA) Read More »

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