Class 1. Persistent Pulmonary Hypertension of the Newborn

Clinical phenotype of pulmonary vascular disease requiring treatment in extremely preterm infants

Ki Teak Hong, Seung Han Shin, Ee‑Kyung Kim, Han‑Suk KimSeoul National University Children’s Hospital.Republic of Korea BioMedical Central PediatricsBMC Pediatr 2024; 24: DOI: 10.1186/s12887-024-04943-4 AbstractBackground: Pulmonary vascular disease (PVD) and pulmonary hypertension (PH) is a significant disorder affecting prognosis of extremely preterm infants. However, there is still a lack of a consensus on the definition and optimal […]

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Risk Factors and Mortality in Newborns with Persistent Pulmonary Hypertension: A Six-Year Single-Center Experience

Ozlem Sahin, Nazife Reyyan Gok, Derya Colak, Taliha Oner, Omer Guran, Funda Yavanoglu Atay, Ilke Mungan AkinUniversity of Health Sciences Türkiye and Umraniye Training and Research Hospital.  Marmara University Faculty of Medicine.Turkey Medical Bulletin of Sisli Eftal HospitalMed Bull Sisli Etfal Hosp 2024; 58: 165–170DOI: 10.14744/SEMB.2024.78614 AbstractObjectives: Persistent pulmonary hypertension (PPHT) of the newborn is a disorder

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Vasopressin as adjunctive therapy in pulmonary hypertension associated with refractory systemic hypotension in term newborns

Felipe Santelices, Daniela Masoli, Javier Katten, Alberto Toso, Matias LucoPontificia Universidad Católica de Chile. Chile Journal of PerinatologyJ Perinatol 2024; DOI: 10.1038/s41372-024-02015-0 AbstractObjective: The use of vasopressin as an adjunctive therapy in pulmonary hypertension associated with refractory systemic hypotension has increased. The objective of our study is to describe its effects on term infants.Study design: Retrospective observational study.

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The Epidemic of Congenital Syphilis in the Indigenous and Rural Populations of South Dakota

Narysse Nicolet, Amrita Bhagia, Megan Torve, Kessa Tribby, Nicole Poppinga, Kimberlee McKay, Maria M. Talavera-BarberUniversity of South Dakota Sanford School of Medicine. Monument Health. Avera McKennan Hospital and University Health CenterUnited States PediatricsPediatrics 2024; DOI: 10.1542/peds.2023-063823 AbstractFrom 2020 to 2023, South Dakota witnessed a substantial increase in cases of congenital syphilis (CS), with the highest rates

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Safety and Tolerability of Continuous Inhaled Iloprost Therapy for Severe Pulmonary Hypertension in Neonates and Infants

Amit V. Krishnan, Victoria Freniere, Rakesh Sahni, Diana P. Vargas Chaves, Sankaran S. Krishnan, Dimitrios Savva, Usha S. KrishnanColumbia University Irving Medical Center and New York-Presbyterian Hospital. New York Medical College.United States ChildrenChildren 2024; DOI: 10.3390/children11060703 AbstractThis is a single-center retrospective study to assess the safety and tolerability of continuous inhaled iloprost use as rescue therapy

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Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension?

Deepika Sankaran, Jessa Rose A. Li, Satyan LakshminrusimhaUniversity of California, Davis.United States ChildrenChildren 2024; DOI: 10.3390/children11060673 AbstractHypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality among term newborns globally. Infants born through meconium-stained amniotic fluid are at risk of developing meconium aspiration syndrome (MAS) and HIE. Simultaneous occurrence of MAS and HIE is a perilous combination

Meconium Aspiration Syndrome, Hypoxic-Ischemic Encephalopathy and Therapeutic Hypothermia-A Recipe for Severe Pulmonary Hypertension? Read More »

Deep Learning Based Prediction of Pulmonary Hypertension in Newborns Using Echocardiograms

Hanna Ragnarsdottir, Ece Ozkan, Holger Michel, Kieran Chin-Cheong, Laura Manduchi, Sven Wellmann, Julia E. VoETH Zurich. Massachusetts Institute of Technology. University Children’s Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John and University of Regensburg.Switzerland, United States and Germany International Journal of Computer VisionInt J Comput Vis 2024; 132: 2567–2584DOI: 10.1007/s11263-024-01996-x AbstractPulmonary hypertension

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Aberrant PGC-1α signaling in a lamb model of persistent pulmonary hypertension of the newborn

Emily A. Mooers, Hollis M. Johnson, Teresa Michalkiewicz, Ujala Rana, Chintamani Joshi, Adeleye J. Afolayan, Ru-Jeng Teng, Girija G. KonduriMedical College of Wisconsin.United States Pediatric ResearchPediatr Res 2024; DOI: 10.1038/s41390-024-03223-2 AbstractBackground: Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by elevated pulmonary vascular resistance (PVR), resulting in hypoxemia. Impaired angiogenesis contributes to high PVR. Pulmonary artery

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Multisystem Inflammatory Syndrome in Neonates Associated with COVID-19 in Neonatal ICU of a Tertiary Care Hospital

Asma Shabbir, Humaira Khurshid, Imran Mahmood KhanFazaia Medical College, Pakistan Air Force Hospital.Pakistan Journal of the College of Physicians and Surgeons PakistanJ Coll Physicians Surg Pak 2024; 34: 727-731 DOI: 10.29271/jcpsp.2024.06.727 AbstractObjective: Neonatal multisystem inflammatory syndrome (MIS-N) is a unique disease of neonates described in several case reports from all over the world with a myriad of

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Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn (PPHN): when to think beyond reversible causes

Stephanie M. Tsoi, Martina Steurer, Hythem Nawaytou, Shannon Cheung, Roberta L. Keller, Jeffrey R. FinemanUniversity of California San Francisco. United States Journal of PediatricsJ Pediatr 2024; DOI: 10.1016/j.jpeds.2024.114131 AbstractObjectives: To describe the typical clinical course of reversible PPHN from perinatal etiologies and compare that with the clinical course of PPHN due to underlying fetal developmental etiologies.Study design: This

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