Animal Models of Pulmonary Vascular Disease and Therapy

Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia

Tsering Stobdan, Pritesh P. Jain, Mingmei Xiong, Vineet Bafna, Jason X.-J. Yuan, Gabriel G. HaddadUniversity of California San Diego. Rady Children’s Hospital.United States Human Molecular GeneticsHum Mol Genet 2022; 31: 1130-1140DOI: 10.1093/hmg/ddab291 AbstractThe molecular mechanisms leading to high-altitude pulmonary hypertension (HAPH) remains poorly understood. We previously analyzed the whole genome sequence of Kyrgyz highland population and […]

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Hepatoma-derived growth factor is associated with pulmonary vascular remodeling and PAH disease severity and survival

Jun Yang, Anjira S. Ambade, Melanie Nies, Megan Griffiths, Rachel Damico, Dhananjay Vaidya, Stephanie Brandal, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, William C. Nichols, Eric D. Austin, Dunbar Ivy, Paul M. Hassoun, Allen D. EverettJohns Hopkins University. Vagelos College of Physicians and Surgeons Columbia University. University of Cincinnati College of Medicine and

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Dichotomous role of integrin-β5 in lung endothelial cells

Neil Blanchard, Patrick A. Link, Daniela Farkas, Brennan Harmon, Jaylen Hudson, Srimathi Bogamuwa, Bryce Piper, Kayla Authelet, Carlyne D. Cool, Rebecca L. Heise, Robert Freishtat, Laszlo FarkasUniversity of Virginia. Ohio State University. Children’s National Health System. University of Colorado. Virginia Commonwealth University.United States Pulmonary CirculationPulm Circ 2022; DOI: 10.1002/pul2.12156 AbstractPulmonary arterial hypertension (PAH) is a progressive,

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Seven-day in vivo testing of a novel, low-resistance, pumpless pediatric artificial lung for long-term support

Brian P. Fallon, Alex J. Thompson, Aaron R. Prater, Skylar Buchan, Trevor Alberts, Mark Hoenerhoff, Alvaro Rojas-Pena, Robert H. Bartlett, Ronald B. HirschlUniversity of Michigan Medical School and Michigan Medicine.United States Journal of Pediatric SurgeryJ Pediatr Surg 2022; 57: 614-623DOI: 10.1016/j.jpedsurg.2022.07.006 AbstractIntroduction: For children with end-stage lung disease that cannot wean from extracorporeal life support (ECLS), a

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Effects of uteroplacental insufficiency on cardiac development in growth-restricted newborn rats

Hsiu-Chu Chou, Chung-Ming ChenTaipei Medical University.Taiwan Journal of the Developmental Origins of Health and DiseaseJ Dev Orig Health Dis 2023; 14: 272-278DOI: 10.1017/S2040174422000575 AbstractFetal growth restriction (FGR) is associated with reduced cardiac function in neonates. Uteroplacental insufficiency (UPI) is the most common cause of FGR. The mechanisms underlying these alterations remain unknown. We hypothesized that UPI

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Utilizing the Precision-Cut Lung Slice to Study the Contractile Regulation of Airway and Intrapulmonary Arterial Smooth Muscle

Yan Bai, Xingbin AiMassachusetts General Hospital and Harvard Medical School.United States Journal of Visualized ExperimentsJ Vis Exp 2022; DOI: 10.3791/63932 AbstractSmooth muscle cells (SMC) mediate the contraction of the airway and the intrapulmonary artery to modify airflow resistance and pulmonary circulation, respectively, hence playing a critical role in the homeostasis of the pulmonary system. Deregulation of

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Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease

Bin Wen, Rui Peng, Pengxu Kong, Zefu Li, Yao Liu, Wenbin Ouyang, Yongquan Xie, Xiaopeng Hu, Qiang Wang, Xiangbin PanNational Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing Chao-Yang Hospital. Beijing Friendship Hospital. Beijing Anzhen Hospital and Capital Medical University.China American Journal of Respiratory Cell and

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Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model

Devashis Mukherjee, Ujala Rana, Alison J. Kriegel, Pengyuan Liu, Teresa Michalkiewicz, Girija Ganesh KonduriRainbow Babies and Children’s Hospital and Case Western Reserve University School of Medicine. Medical College of Wisconsin and Children’s Wisconsin.United States Pediatric ResearchPediatr Res 2022; 93: 551-558DOI: 10.1038/s41390-022-02151-3 AbstractBackground: Persistent pulmonary hypertension of the newborn (PPHN) occurs when pulmonary vascular resistance (PVR) fails to

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OLA1 Phosphorylation Governs the Mitochondrial Bioenergetic Function of Pulmonary Vascular Cells

Paul Sidlowski, Amanda Czerwinski, Yong Liu, Pengyuan Liu, Ru-Jeng Teng, Suresh Kumar, Clive Wells, Kirkwood Pritchard Jr, Girija G. Konduri, Adeleye J. AfolayanMedical College of Wisconsin. United States American Journal of Respiratory Cell and Molecular BiologyAm J Respir Cell Mol Biol 2022; DOI: 10.1165/rcmb.2022-0186OC AbstractMitochondrial function and metabolic homeostasis are integral to cardiovascular function and influence

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Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension

Lea C. Steffes, Maya E. KumarStanford University School of Medicine.United States Bio-protocolBio Protoc 2022; 12: DOI: 10.21769/BioProtoc.4273 AbstractPulmonary hypertension (PH) is a heterogenous and incurable disease marked by varying degrees of pulmonary vascular remodeling. This vascular remodeling, which includes thickening of the smooth muscle layer (an early finding) and formation of occlusive neointimal lesions (a late

Chronic Daily House Dust Mite Exposure in Mice is an Effective Model to Quantify the Effect of Pharmacologic Agents on Discrete Stages of Artery Remodeling in Pulmonary Hypertension Read More »

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