Animal Models of Pulmonary Vascular Disease and Therapy

Vasopressin versus epinephrine during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets

Megan O’Reilly, Tze-Fun Lee, Po-Yin Cheung, Georg M. SchmolzerRoyal Alexandra Hospital and University of Alberta.Canada Resuscitation PlusResus Plus 2023; 15DOI: 10.1016/j.resplu.2023.100427 AbstractBackground: Epinephrine is currently the only recommended cardio-resuscitative medication for use in neonatal cardiopulmonary resuscitation (CPR), as per the consensus of science and treatment recommendations. An alternative medication, vasopressin, might be beneficial in neonatal CPR due […]

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SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics

Shreya Sangam, Xutong Sun, Tae-Hwi Schwantes-An, Manivannan Yegambaram, Qing Lu, Yinan Shi, Todd Cook, Amanda Fisher, Andrea L. Frump, Anna Coleman, Yanan Sun, Shuxin Liang, Howard Crawford, Katie A. Lutz, Avinash D. Maun, Michael W. Pauciulo, Jason H. Karnes, Ketul R. Chaudhary, Duncan J. Stewart, Paul R. Langlais, Mohit Jain, Mona Alotaibi, Tim Lahm, Yan

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Drug-eluting stents ameliorate pulmonary vein stenotic changes in pigs in vivo

Takeshi Furukawa, Masahiko Kishiro, Hideo Fukunaga, Masahiro Ohtsuki, Ken Takahashi, Katsumi Akimoto, Toshiaki Shimizu, Shiori Kawasaki, Toshio KumasakaJuntendo University School of Medicine.Japan Pediatric CardiologyPediatr Cardiol 2010; 31: 773-779DOI: 10.1007/s00246-010-9695-8 AbstractThe outcome of stent implantation for pulmonary vein stenosis (PVS) in children remains poor. Several reports describe placing drug-eluting stents to treat PVS, but their effectiveness remains

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Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis

Jiaquan Zhu, HarukiIde, Yaqin Yana Fu, Anouk-Martine Teichert, Hideyuki Kato, Richard D. Weisel, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneThe Hospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovasc Surg 2014; 148: 2550-2557DOI: 10.1016/j.jtcvs.2014.07.050 AbstractObjectives: Pulmonary vein stenosis (PVS) is a relentless disease with

Losartan ameliorates “upstream” pulmonary vein vasculopathy in a piglet model of pulmonary vein stenosis Read More »

Pulmonary vein stenosis and the pathophysiology of “upstream” pulmonary veins

Hideyuki Kato, Yaqin Yana Fu, Jiaquan Zhu, Shabana Aafaqi, Otto Rahkonen, Cameron Slorach, Alexandra Traister, Chung Ho Leung, David Chiasson, Luc Mertens, Lee Benson, Richard D. Weisel, Boris Hinz, Jason T. Maynes, John G. Coles, Christopher A. CaldaroneHospital for Sick Children and University of Toronto. Toronto General Hospital. Canada Journal of Thoracic and Cardiovascular SurgeryJ

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Pulmonary hypertension due to left heart disease causes intrapulmonary venous arterialization in rats

Yoshitaka Fujimoto, Takashi Urashima, Fumie Kawachi, Toru Akaike, Yoichiro Kusakari, Hiroyuki Ida, Susumu MinamisawaJikei University School of Medicine.Japan Journal of Thoracic and Cardiovascular SurgeryJ Thorac Cardiovas Surg 2017; 154: 1742-1753DOI: 10.1016/j.jtcvs.2017.06.053 AbstractObjective: A rat model of left atrial stenosis-associated pulmonary hypertension due to left heart diseases was prepared to elucidate its mechanism.Methods: Five-week-old Sprague-Dawley rats were randomly divided

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Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A

Hanrong Cheng, Li Chen, Yongli Wei, Tianyong Hu, Dongcai Li, Benqing WuShenzhen People’s Hospital, The Second Clinical Medical College of Jinan University and First Affiliated Hospital of Southern University of Science and Technology. Longgang ENT Hospital.University of Chinese Academy of Science-Shenzhen Hospital.China Journal of Bioenergetics and BiomembranesJ Bioenerg Biomembr 2021; 53: 13-23DOI: 10.1007/s10863-020-09863-3 AbstractBronchopulmonary dysplasia (BPD)

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A Read More »

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions

Evan M. Zahn, Eason Abbott, Neil Tailor, Shyam Sathanandam, Dustin ArmerCedars Sinai Medical Center. Renata Medical Company. Morgan Stanley Children’s Hospital. LeBonheur Children’s Hospital.United States Catheterization and Cardiovascular InterventionsCatheter Cardiovasc Interv 2021; 98: 117-127DOI: 10.1002/ccd.29706 AbstractObjectives: This study sought to obtain in vivo data on a new stent and delivery system specifically designed for implantation in infants

Preliminary testing and evaluation of the renata minima stent, an infant stent capable of achieving adult dimensions Read More »

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine

Ryan Pewowaruk, Luke Lamers, Alejandro Roldán-AlzateUniversity of Wisconsin.United States Annals of Biomedical EngineeringAnn Biomed Eng 2021; 49: 2365-2376DOI: 10.1007/s10439-021-02780-5 AbstractBranch pulmonary artery stenosis (PAS) commonly occurs in congenital heart disease and the pressure gradient over a stenotic PA lesion is an important marker for re-intervention. Image based computational fluid dynamics (CFD) has shown promise for non-invasively

Accelerated Estimation of Pulmonary Artery Stenosis Pressure Gradients with Distributed Lumped Parameter Modeling vs. 3D CFD with Instantaneous Adaptive Mesh Refinement: Experimental Validation in Swine Read More »

Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model

Ryan J. Pewowaruk, Gregory P. Barton, Cody Johnson, J. Carter Ralphe, Christopher J. Francois, Luke Lamers, Alejandro Roldán‑AlzateUniversity of Wisconsin-Madison.United States Journal of Cardiovascular Magnetic ResonanceJ Cardiovasc Magn Reson 2021; 13: DOI: 10.1186/s12968-021-00709-4 AbstractBackground: Branch pulmonary artery (PA) stenosis (PAS) commonly occurs in patients with congenital heart disease (CHD). Prior studies have documented technical success and clinical

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