Animal Models of Pulmonary Vascular Disease and Therapy

Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia

Ryosuke Miura, Atsuto Onoda, Azusa Okamoto, Toshihiko Suzuki, Takahiro Kanzawa, Sakiko Suzuki, Kazuto Ueda, Shinobu Shimizu, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki SatoNagoya University Hospital and Nagoya University Graduate School of Medicine. Sanyo-Onoda City University. Japan Stem Cell Research and TherapyStem Cell Res Ther 2026; 17: DOI: 10.1186/s13287-026-05086-2 AbstractBackground: Neonatal bronchopulmonary dysplasia (BPD) is a lung injury caused […]

Intravenously delivered multilineage-differentiating stress-enduring cells dampen hyperoxia-induced lung injury in a rat model with features of bronchopulmonary dysplasia Read More »

Developing a Digital Twin of the Cardiopulmonary System in a Mouse: Inferring Hemodynamics from Sparse Measurements

Vitaly O. Kheyfets, Kenzo Ichimura, Paul M. Heerdt, Mengqian Zhang, Ella Lyon, Kurt R. Stenmark, Edda SpiekerkoetterUniversity of Colorado School of Medicine and University of Colorado Anschutz Medical Campus. Stanford University. Yale School of Medicine.United States Annals of Biomedical EngineeringAnn Biomed Eng 2026; DOI: 10.1007/s10439-026-04107-8 AbstractPurpose: The use of rodent models in the study of cardiopulmonary disease

Developing a Digital Twin of the Cardiopulmonary System in a Mouse: Inferring Hemodynamics from Sparse Measurements Read More »

Echocardiography Assessment of Cardiac Function and Pulmonary Hypertension in Lambs

Yasmine N. White, Matthew Douglass, Reagan Cathcart, Jakob Van Boerum, Andrew Rebentisch, Kurt H. Albertine, Marjanna DahlUniversity of Utah.United States Journal of Visualized ExperimentsJ Vis Exp 2026; DOI: 10.3791/70686 AbstractPremature birth is strongly associated with cardiac dysfunction, including impaired ventricular function and altered cardiac structure, which can lead to progressive heart failure and other short- and

Echocardiography Assessment of Cardiac Function and Pulmonary Hypertension in Lambs Read More »

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation

Luz M. Villanueva, Homare Ito, Xiulan Qi, Svetlana P. Chapoval, Rose M. Viscardi, Stefanie N. Vogel, Achsah D. KeeganUniversity of Maryland School of Medicine. SemaPlex LLC. VA Maryland Health Care System. United States ImmunoHorizonsImmunohorizons 2026; 10: DOI: 10.1093/immhor/vlag028 AbstractWe previously reported that global insulin receptor substrate-2 (IRS2)-deficient mice demonstrated enhanced pulmonary vascular remodeling in response to

Absence of insulin receptor substrate 2 (IRS2) in myeloid cells results in enhanced hypoxia-induced remodeling of the pulmonary vasculature and heart with modest effects on allergic lung inflammation Read More »

The NLRP3 Inflammasome Increases Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension

Emmanouil Mavrogiannis, Rebeca Weldeghebreal, Iris R. Schilthuis, Zain K. Fal, Niels J. Kloosterhuis, Mirjam H. Koster, Wim Timens, Johannes M. Douwes, Rolf M. F. Berger, Marit WesterterpBeatrix Children’s Hospital, University Medical Center Groningen and University of Groningen. Netherlands Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70354 AbstractPulmonary arterial hypertension (PAH) is a progressive vasculopathy leading to right-sided

The NLRP3 Inflammasome Increases Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension Read More »

The Role of Piezo Ion Channels in Pulmonary Hypertension

Kewei Chen, Lingchen Li, Yajie Huang, Lixia Ye, Yu Wang, Ziming Zhang, Chengcheng Hang, Qiqi Li, Qianyun Cao, Lizhong DuChildren’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Children and Adolescents’ Health and Diseases. Second Affiliated Hospital and School of Medicine of Zhejiang University. China Pulmonary CirculationPulm Circ 2026; 16: DOI: 10.1002/pul2.70360

The Role of Piezo Ion Channels in Pulmonary Hypertension Read More »

Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia

Heleen M. Kool, Petra E. Bürgisser, Gabriela G. Edel, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Panagiotis Liakopoulos, Petros Kolovos, Wilfred F. J. Ijcken, Robbert J. RottierSophia Children’s Hospital. Erasmus Medical Center. Democritus University of Thrace. Netherlands and Greece Cellular and Molecular Life SciencesCell Mol Life Sci 2026; DOI: 10.1007/s00018-026-06319-6 AbstractCongenital diaphragmatic hernia (CDH) is a rare

Reduced KLF4 expression in endothelial cells triggers pulmonary vascular abnormalities associated with experimental congenital diaphragmatic hernia Read More »

A large animal model of heritable pulmonary arterial hypertension using gene-edited BMPR2 sheep

Sanjeev A. Datar, Nicholas Werry, Austin R. Brown, Devon S. Fitzpatrick, Oluwafemi Falade, Josephine F. Trott, Rachel Hutchings, Elena K. Amin, Jessica M. Morgan, Hythem Nawaytou, Gail H. Deutsch, Eric G. Johnson, Omar A. Gonzales Viera, Thomas F. Bishop, Tara Urbano Beach, Bret R. McNabb, Eric D. Austin, Jeffrey R. Fineman, Alison L. Van EenennaamUniversity

A large animal model of heritable pulmonary arterial hypertension using gene-edited BMPR2 sheep Read More »

Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia

Chantal Gaudet, Kathrine L. Daniel, Sophie Holcik, Ali Hamraghani, Behzad Yeganeh, Robert P JankovChildren’s Hospital of Eastern Ontario. University of Ottawa. Canada American Journal of Physiology Lung Cellular and Molecular PhysiologyAm J Physiol Lung Cell Mol Physiol 2026; DOI: 10.1152/ajplung.00090.2026 AbstractBronchopulmonary dysplasia (BPD) is a neonatal lung injury characterized by inflammation, and alveolar and vascular hypoplasia

Inhibition of thrombospondin-1 signaling prevents experimental bronchopulmonary dysplasia Read More »

SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension

Xiao-He Xu, Yi Shen, Min Chen, Yu-Xin Miao, Lin Cheng, Yang-Han-Yue Zhao, Yang Fang, Dai-Ji Jiang, Fang Yu, Yang-Yang He, Zhuo-Yuan Xu, Li-Jun Fu, Li-Wei Wu, Hao Zhang, Yi YanShanghai Children’s Medical Center, National Children’s Medical Center and Shanghai Jiao Tong University School of Medicine. Henan University. Second Affiliated Hospital, Yuying Children’s Hospital, Wenzhou Medical

SnRNA-seq identifies FN1-SDC4 axis triggering epicardial activation in right ventricular remodeling in pulmonary hypertension Read More »

Scroll to Top