Animal Models of Pulmonary Vascular Disease and Therapy

Inhibition of poly (ADP-ribose) Polymerase-1 (PARP-1) improves endothelial function in pulmonary hypertension

Mohammad Shafiq, Zahid Rasool Lone, Adam Olaitan Abdulkareem, Gurpreet Kaur, Sai Navya, Himalaya Singh, Kumaravelu Jagavelu, Kashif HanifCSIR-Central Drug Research Institute and Academy of Scientific and Innovative Research. Ann & Robert H. Lurie Children’s Hospital. University of Illorin.India and United States Pulmonary Pharmacology and TherapeuticsPulm Pharmacol Ther 2023; 80: DOI: 10.1016/j.pupt.2023.102200 AbstractEndothelial dysfunction is critical in […]

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Sildenafil Improves Pulmonary Vascular Remodeling in a Rat Model of Persistent Pulmonary Hypertension of the Newborn

Lili Kang, Xianghong Liu, Zilong Li, Xiao Mei Li, Yujie Han, Chen Liu, Cuifen Zhao, Xiaoying LiQilu Children’s Hospital of ShanDong University. Qilu Hospital and Cheeloo College of MedicineChina Journal of Cardiovascular PharmacologyJ Cardiovasc Pharmacol 2023; 81: 232-239DOI: 10.1097/FJC.0000000000001373 AbstractPersistent pulmonary hypertension of the newborn (PPHN) is characterized by pulmonary arterial remodeling mainly because of apoptosis

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Impaired cell-cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development

Debao Li, Jing Wang, Yuan Fang, Yuqing Hu, Yingying Xiao, Qing Cui, Chuan Jiang, Sijuan Sun, Hao Chen, Lincai Ye, Qi SunShanghai Children’s Medical Center. Shanghai Jiao Tong University. Shanghai Ninth People’s Hospital. China Respiratory ResearchRespir Res 2023; 24: DOI: 10.1186/s12931-023-02319-3 AbstractBackground: Pulmonary hypoperfusion is common in children with congenital heart diseases (CHDs) or pulmonary hypertension (PH)

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Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups

Brianna M. Liberio, Gregory Seedorf, Danielle E. Soranno, John R. Montford, Sarah G. Faubel, Andres Hernandez, Steven H. Abman, Jason GienIndiana University School of Medicine. University of Colorado School of Medicine. Rocky Mountain Regional VA Medical Center. United States Pediatric ResearchPediatr Res 2023; DOI: 10.1038/s41390-023-02625-y AbstractBackground: Acute kidney injury (AKI) is common in sick neonates and associated

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WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension

Ananya Chakraborty, Abinaya Nathan, Mark Orcholski, Stuti Agarwal, Elya A. Shamskhou, Natasha Auer, Ankita Mitra, Eleana Stephanie Guardado, Gowri Swaminathan, David F. Condon, Joyce Yu, Matthew McCarra, Nicholas H. Juul, Alden Mallory, Roberto A. Guzman-Hernandez, Ke Yuan, Vanesa Rojas, Joseph T. Crossno, Lai-Ming Yung, Paul B. Yu, Thomas Spencer, Robert A. Winn, Andrea Frump, Vijaya

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Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology

Andrew V. Stainsby, Philip L. J. DeKoninck, Kelly J. Crossley, Alison Thiel, Megan J. Wallace, James T. Pearson, Aidan J. Kashyap, Michelle K. Croughan, Beth A. Allison, Ryan Hodges, Marta Thio, Andreas W. Flemmer, Erin V. McGillick, Arjan B. te Pas, Stuart B. Hooper, Marcus J. KitchenHudson Institute of Medical Research, Victoria Heart Institute and

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Vascular and pulmonary effects of ibuprofen on neonatal lung development

Xueyu Chen, Dongshan Han, Xuan Wang, Xuemei Huang, Zilu Huang, Yijun Liu, Junyan Zhong, Frans J. Walther, Chuanzhong Yang, Gerry T. M. WagenaarAffiliated Shenzhen Maternity and Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University. David Geffen School of Medicine, University of California Los Angeles. Lundquist Institute for Biomedical Innovation at Harbor-UCLA

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Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission

Qing Lu, Xutong Sun, Manivannan Yegambaram, Wojciech Ornatowski, Xiaomin Wu, Hui Wang, Alejandro Garcia-Flores, Victoria Da Silva, Evgen A. Zemskov, Haiyang Tang, Jeffrey R. Fineman, Kim Tieu,Ting Wang, Stephen M. BlackFlorida International University. University of Arizona Health Sciences. University of California San Francisco. United States Journal of Biological ChemistryJ Biol Chem 2023; 299:DOI: 10.1016/j.jbc.2023.103067 AbstractMitochondrial fission

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Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

Miranda K. Culley, Rashmi J. Rao, Monica Mehta, Jingsi Zhao, Wadih El Khoury, Lloyd D. Harvey, Dror Perk, Yi Yin Tai, Ying Tang, Sruti Shiva, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y. ChanUniversity of Pittsburgh School of Medicine and University of Pittsburgh Medical Center. Albert Einstein College of Medicine. Stanford Children’s Health and Stanford

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Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension

Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B. GrahamUniversity of California San Francisco. Zuckerberg San Francisco General Hospital. University of Colorado Anschutz Medical Campus. Stanford University. Universidade de Pernambuco.United States and Brazil

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension Read More »

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